公开(公告)号：US20090275547A1

公开(公告)日：2009-11-05

申请号：US12112748

申请日：2008-04-30

申请人： Eric Meggers ,  Peng Xie ,  Douglas S. Williams ,  Ronen Marmorstein

发明人： Eric Meggers ,  Peng Xie ,  Douglas S. Williams ,  Ronen Marmorstein

IPC分类号： A61K31/295 ,  C07F15/00

CPC分类号： C07D498/22 ,  C07D487/14

摘要： Provided are novel organometallic compounds that inhibit PI3K lipid kinase and phospho-AKT in human melanoma cells, and also inhibit the migration of melanoma cells. The present invention is also directed to methods for inhibiting cancer cell proliferation, migration or both comprising contacting a cancer cell with a disclosed organometallic kinase inhibitor. Also disclosed are methods for treating a kinase-affected disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a disclosed organometallic kinase inhibitor.

摘要翻译： 提供了抑制人黑素瘤细胞中PI3K脂质激酶和磷酸化AKT的新型有机金属化合物，并且还抑制黑素瘤细胞的迁移。 本发明还涉及抑制癌细胞增殖，迁移或两者的方法，包括使癌细胞与公开的有机金属激酶抑制剂接触。 还公开了用于治疗激酶受影响的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的所公开的有机金属激酶抑制剂。

公开(公告)号：US08106039B2

公开(公告)日：2012-01-31

申请号：US12112748

申请日：2008-04-30

申请人： Eric Meggers ,  Peng Xie ,  Douglas S. Williams ,  Ronen Marmorstein

发明人： Eric Meggers ,  Peng Xie ,  Douglas S. Williams ,  Ronen Marmorstein

IPC分类号： A61K31/555 ,  C07F15/00

CPC分类号： C07D498/22 ,  C07D487/14

摘要： Provided are novel organometallic compounds that inhibit PI3K lipid kinase and phospho-AKT in human melanoma cells, and also inhibit the migration of melanoma cells. The present invention is also directed to methods for inhibiting cancer cell proliferation, migration or both comprising contacting a cancer cell with a disclosed organometallic kinase inhibitor. Also disclosed are methods for treating a kinase-affected disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a disclosed organometallic kinase inhibitor.

摘要翻译： 提供了抑制人黑素瘤细胞中PI3K脂质激酶和磷酸化AKT的新型有机金属化合物，并且还抑制黑素瘤细胞的迁移。 本发明还涉及抑制癌细胞增殖，迁移或两者的方法，包括使癌细胞与公开的有机金属激酶抑制剂接触。 还公开了用于治疗激酶受影响的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的所公开的有机金属激酶抑制剂。

公开(公告)号：US20140029762A1

公开(公告)日：2014-01-30

申请号：US13557895

申请日：2012-07-25

申请人： Peng Xie ,  Sean M. White ,  Kantapon Kaewtip ,  Lance Williams

发明人： Peng Xie ,  Sean M. White ,  Kantapon Kaewtip ,  Lance Williams

IPC分类号： H04B15/00 ,  H04R3/00 ,  H04R25/00

CPC分类号： H04R5/027 ,  G10L21/0208 ,  G10L21/0232 ,  G10L25/84 ,  G10L25/93 ,  H04B2001/3866 ,  H04M1/05 ,  H04M1/6066 ,  H04R3/00 ,  H04R3/005 ,  H04R2410/03 ,  H04R2410/05 ,  H04R2420/07 ,  H04R2430/03 ,  H04R2460/13

摘要： A platform that is configured to be removably placed symmetrically on or about a user's head has at least a first transducer configured to capture vibration of the user's skull or facial movement generated by the user's voice activity and to detect the user's speaking activity. This first transducer converts the vibration or facial movement into a first electrical audio signal. The electrical audio signal from the first transducer is processed by circuitry or embodied software as voiced frames and/or as unvoiced frames, in which the voiced frames and/or the unvoiced frames are defined based at least on the first electrical audio signal. Multiple embodiments follow from this: where the first transducer is a vibration sensor; where voice is captured by an air microphone and filtering adaptation differs for the voiced versus unvoiced frames as defined by the first transducer, and another with at least three air microphones.

摘要翻译： 被配置为可拆卸地对称地放置在使用者的头部上或附近的平台具有至少第一传感器，其被配置为捕获用户的头骨的振动或由用户的语音活动产生的面部运动并检测用户的说话活动。 该第一传感器将振动或面部运动转换为第一电音频信号。 来自第一换能器的电音频信号由电路或实施的软件作为有声帧和/或无声帧来处理，其中，至少基于第一电音频信号定义有声帧和/或无声帧。 多个实施例如下：第一传感器是振动传感器; 其中声音被空气麦克风捕获，并且对于由第一换能器定义的浊音与无声帧相比，滤波适配不同，另一个具有至少三个空气麦克风。

公开(公告)号：US20110288086A1

公开(公告)日：2011-11-24

申请号：US13112354

申请日：2011-05-20

申请人： Jianqi Li ,  Zixue Zhang ,  Peng Xie ,  Qingwei Zhang

发明人： Jianqi Li ,  Zixue Zhang ,  Peng Xie ,  Qingwei Zhang

IPC分类号： A61K31/535 ,  A61P35/00 ,  A61K31/4985 ,  C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： At least one active pharmaceutical ingredient is chosen from polycyclic quinazolines of formula V, pharmaceutically acceptable salts thereof, and hydrates of the pharmaceutically acceptable salts. The active pharmaceutical ingredients disclosed may be inhibitors of protein tyrosine kinase inhibitors and/or aurora kinase. The active pharmaceutical ingredients can be used for treating cancers susceptible to treatment with protein tyrosine kinase inhibitors and/or aurora kinase inhibitors.

摘要翻译： 至少一种活性药物成分选自式V的多环喹唑啉，其药学上可接受的盐和药学上可接受的盐的水合物。 所公开的活性药物成分可以是蛋白酪氨酸激酶抑制剂和/或极光激酶的抑制剂。 活性药物成分可用于治疗易于用蛋白酪氨酸激酶抑制剂和/或极光激酶抑制剂治疗的癌症。

公开(公告)号：US20100065285A1

公开(公告)日：2010-03-18

申请号：US12522025

申请日：2007-11-15

申请人： Hongbao Guo ,  Zanfeng Zhang ,  Guoxing Zhang ,  Peng Xie

发明人： Hongbao Guo ,  Zanfeng Zhang ,  Guoxing Zhang ,  Peng Xie

IPC分类号： A62C31/00

CPC分类号： A62C99/0045 ,  A62C5/006 ,  A62C31/05

摘要： A new bi-directional horizontal spraying aerosol fire-extinguishing apparatus is disclosed, which comprises a shell structure, an aerosol generator including an aerosol generating agent and disposed inside the shell structure, and a control unit for initiating the aerosol generator. The bi-directional horizontal spraying aerosol fire-extinguishing apparatus of the present invention is characterized in that both ends of the shell structure or of the aerosol generator are respectively provided with an aerosol exhaust passage. The advantages of the present apparatus are in that it can reduce the spraying time of the aerosol extinguishing agent in the case of ensuring the fire-suppression efficiency, and increase the charge capacity of the fire-extinguishing apparatus, so that the capacity efficiency of the present apparatus is totally increased, and the present apparatus is easy and safe to be installed and does not occupy the useful space.

摘要翻译： 公开了一种新的双向水平喷雾气溶胶灭火装置，其包括壳结构，包括气溶胶发生剂的气溶胶发生器并且设置在壳结构内部，以及用于起动气溶胶发生器的控制单元。 本发明的双向水平喷雾气溶胶灭火装置的特征在于，壳结构或气溶胶发生器的两端分别设置有气溶胶排气通道。 本装置的优点在于，在确保灭火效果的情况下，可以减少气溶胶灭火剂的喷雾时间，并且能够提高灭火装置的充电能力， 本装置完全增加，本装置容易安全，不占用有用空间。

公开(公告)号：US20150256450A1

公开(公告)日：2015-09-10

申请号：US14427866

申请日：2012-09-28

申请人： Siyu YANG ,  Zhiyong SHEN ,  Peng XIE ,  Yong TANG ,  Ping LUO ,  Junqing XIE ,  Linpeng TANG ,  Mihalis YANNAKAKIS ,  Robert E TARJAN ,  David LEE ,  Hewlett-Packard Development Company, L. P.

发明人： Siyu Yang ,  Zhi-Yong Shen ,  Peng Xie ,  Tang Yong ,  Ping Luo ,  Jun-Qing Xie ,  Linpeng Tang ,  Mihalis Yannakakis ,  Robert Tarjan ,  David Lee

IPC分类号： H04L12/753 ,  H04L12/24 ,  H04L12/44

CPC分类号： H04L45/48 ,  H04L12/44 ,  H04L41/0886 ,  H04L45/14 ,  H04L45/54

摘要： A system and method for generating shape graphs for a routing table are described herein. The method includes splitting a binary trie representing a routing table of a router into a number of layers, wherein each layer includes a number of nodes. The method also includes, for each layer, determining a number of groups of isomorphic nodes and merging the isomorphic nodes within each group to generate a shape graph.

摘要翻译： 本文描述了用于生成路由表的形状图的系统和方法。 该方法包括将表示路由器的路由表的二进制代码分割成多个层，其中每个层包括多个节点。 该方法还包括对于每个层，确定多个同构节点的数量组并且合并每个组内的同构节点以生成形状图。

公开(公告)号：US09094749B2

公开(公告)日：2015-07-28

申请号：US13557895

申请日：2012-07-25

申请人： Peng Xie ,  Sean M. White ,  Kantapon Kaewtip ,  Lance Williams

发明人： Peng Xie ,  Sean M. White ,  Kantapon Kaewtip ,  Lance Williams

IPC分类号： H04B15/00 ,  H04R5/027 ,  H04R3/00 ,  H04B1/3827 ,  H04M1/05 ,  H04M1/60

CPC分类号： H04R5/027 ,  G10L21/0208 ,  G10L21/0232 ,  G10L25/84 ,  G10L25/93 ,  H04B2001/3866 ,  H04M1/05 ,  H04M1/6066 ,  H04R3/00 ,  H04R3/005 ,  H04R2410/03 ,  H04R2410/05 ,  H04R2420/07 ,  H04R2430/03 ,  H04R2460/13

摘要： A platform that is configured to be removably placed symmetrically on or about a user's head has at least a first transducer configured to capture vibration of the user's skull or facial movement generated by the user's voice activity and to detect the user's speaking activity. This first transducer converts the vibration or facial movement into a first electrical audio signal. The electrical audio signal from the first transducer is processed by circuitry or embodied software as voiced frames and/or as unvoiced frames, in which the voiced frames and/or the unvoiced frames are defined based at least on the first electrical audio signal. Multiple embodiments follow from this: where the first transducer is a vibration sensor; where voice is captured by an air microphone and filtering adaptation differs for the voiced versus unvoiced frames as defined by the first transducer, and another with at least three air microphones.

摘要翻译： 被配置为可拆卸地对称地放置在使用者的头部上或附近的平台具有至少第一传感器，其被配置为捕获用户的头骨的振动或由用户的语音活动产生的面部运动并检测用户的说话活动。 该第一传感器将振动或面部运动转换为第一电音频信号。 来自第一换能器的电音频信号由电路或实施的软件作为有声帧和/或无声帧来处理，其中，至少基于第一电音频信号定义有声帧和/或无声帧。 多个实施例如下：第一传感器是振动传感器; 其中声音被空气麦克风捕获，并且对于由第一换能器定义的浊音与无声帧相比，滤波适配不同，另一个具有至少三个空气麦克风。

公开(公告)号：US20130219347A1

公开(公告)日：2013-08-22

申请号：US13400445

申请日：2012-02-20

申请人： Yi Zou ,  Swamy Muddu ,  Lynn T. Wang ,  Vito Dai ,  Luigi Capodieci ,  Peng Xie

发明人： Yi Zou ,  Swamy Muddu ,  Lynn T. Wang ,  Vito Dai ,  Luigi Capodieci ,  Peng Xie

IPC分类号： G06F17/50

CPC分类号： G03F1/70

摘要： Methods for fabricating semiconductor devices are provided. In an embodiment, a method of fabricating a semiconductor device includes scanning a circuit design layout and proposing patterns for decomposed layouts. The proposed patterns are then compared with a library of prior patterns including a category of forbidden patterns and a category of preferred patterns. If a selected proposed pattern matches a forbidden pattern, the selected proposed pattern is eliminated. If the selected proposed pattern matches a preferred pattern, then the selected proposed pattern is identified for use in the decomposed layouts. Decomposed layouts are generated from the identified patterns. A plurality of masks is fabricated based on the decomposed layouts. Then a multiple patterning lithographic technique is performed with the plurality of masks on a semiconductor substrate.

摘要翻译： 提供制造半导体器件的方法。 在一个实施例中，制造半导体器件的方法包括扫描电路设计布局并提出用于分解布局的图案。 然后将所提出的模式与包括禁止模式类别和优选模式类别的先前模式的库进行比较。 如果所选择的提议模式匹配禁止模式，则删除所选择的提议模式。 如果所选择的提出的模式匹配优选模式，则所选择的提出的模式被识别用于分解的布局。 分辨的布局是从识别的图案生成的。 基于分解的布局制造多个掩模。 然后用半导体衬底上的多个掩模进行多重图形化光刻技术。

公开(公告)号：US08778948B2

公开(公告)日：2014-07-15

申请号：US13141803

申请日：2009-12-22

申请人： Jianqi Li ,  Guan Wang ,  Guisen Zhang ,  Xiangping Yang ,  Peng Xie ,  Linjie Zhang ,  Xiangqing Xu ,  Yumei Wang

发明人： Jianqi Li ,  Guan Wang ,  Guisen Zhang ,  Xiangping Yang ,  Peng Xie ,  Linjie Zhang ,  Xiangqing Xu ,  Yumei Wang

IPC分类号： A61K31/495 ,  A61K31/496 ,  C07D295/088 ,  C07D403/08 ,  C07D417/08

CPC分类号： C07D241/04 ,  C07D209/34 ,  C07D235/26 ,  C07D277/68 ,  C07D295/08 ,  C07D295/088 ,  C07D295/096

摘要： The invention relates to a substituted phenylpiperazine aryl alkanol derivative represented by the following general formula and its salt and hydrate, wherein C1 and C2 represent chiral carbon atoms, and the compound is one of the six isomers: (1RS, 2SR), (1RS, 2RS), (1R, 2S), (1S, 2S), (1R, 2R) or (1S, 2R); and R, R1, R2, R3 and Ar are as defined in the specification. The derivative is non-opioid analgesic, has good analgesic effect and relatively small side effects. The invention also relates to a composition comprising the derivative and its use.

摘要翻译： 本发明涉及由以下通式表示的取代苯基哌嗪芳基链烷醇衍生物及其盐和水合物，其中C1和C2代表手性碳原子，该化合物是六种异构体之一：（1RS，2SR），（1RS， 2RS），（1R，2S），（1S，2S），（1R，2R）或（1S，2R）; 并且R，R 1，R 2，R 3和Ar如说明书中所定义。 该衍生物为非阿片类镇痛药，镇痛效果好，副作用小。 本发明还涉及包含该衍生物及其用途的组合物。

公开(公告)号：US20130051585A1

公开(公告)日：2013-02-28

申请号：US13221121

申请日：2011-08-30

申请人： Leo Karkkainen ,  Lance Williams ,  Peng Xie

发明人： Leo Karkkainen ,  Lance Williams ,  Peng Xie

IPC分类号： H04R1/10

CPC分类号： H04R1/1075 ,  H04R3/14 ,  H04R2460/13

摘要： An apparatus including an air-conduction transducer and a bone conduction transducer. The air-conduction transducer is configured to convert a first frequency band component of an electrical audio signal into acoustic energy to be delivered to an ear canal of a user. The bone conduction transducer is configured to convert a second, at least partially different, frequency band component of the electrical audio signal into mechanical energy to be delivered to a skull of the user. The apparatus is configured to deliver both forms of the energies to the user at a substantially same time to provide a combined audio delivery result to the user.

摘要翻译： 一种包括空气传导换能器和骨传导换能器的装置。 空气传导换能器被配置为将电音频信号的第一频带分量转换成要输送到用户的耳道的声能。 骨传导换能器被配置为将电音频信号的第二，至少部分不同的频带分量转换成要传递给用户头骨的机械能。 该装置被配置为在基本相同的时间向用户传送两种形式的能量，以向用户提供组合的音频传送结果。