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    Intraluminal stent
    1.
    发明授权
    Intraluminal stent 失效
    管腔内支架

    公开(公告)号：US5951586A

    公开(公告)日：1999-09-14

    申请号：US853204

    申请日：1997-05-09

    申请人： Eric P. Berg ,  Rodney G. Wolff ,  Elaine P. Lindell ,  Paul V. Trescony ,  Matthew A. Bergan ,  Robert S. Schwartz

    发明人： Eric P. Berg ,  Rodney G. Wolff ,  Elaine P. Lindell ,  Paul V. Trescony ,  Matthew A. Bergan ,  Robert S. Schwartz

    IPC分类号： A61F2/00 ,  A61F2/07 ,  A61F2/88 ,  A61F2/89 ,  B29C41/14 ,  B29C41/20 ,  A61M29/00

    CPC分类号： A61F2/07 ,  B29C41/14 ,  B29C41/20 ,  A61F2/88 ,  A61F2/89 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2240/001 ,  B29K2105/04 ,  B29L2031/7532 ,  Y10S623/921

    摘要： Intraluminal stents and methods of manufacturing intraluminal stents are disclosed in which the stents have a plurality of recesses in the body of the stent, at least some of the recesses preferably providing a plurality of passageways between the inner and outer surfaces of the stent. The preferred stents are constructed of films on support structures having spaced apart elements, with the films having a thickness of between about 25 micrometers and about 400 micrometers. The stent can also be treated with an antithrombotic or a thrombolytic substance and, in some cases, the stents can incorporate therapeutic agents for delivery. The methods of manufacturing stents include forming the films using a solid particulate material that can be substantially removed after the film is formed, thereby forming the recesses and corresponding passageways described above. In preferred methods, the solid particulate material is soluble in a solvent in which the film is substantially insolvent.

    摘要翻译： 公开了腔内支架和制造管腔内支架的方法，其中支架在支架的主体中具有多个凹部，至少一些凹槽优选地在支架的内表面和外表面之间提供多个通道。 优选的支架由具有间隔开的元件的支撑结构上的膜构成，膜的厚度在约25微米至约400微米之间。 支架也可以用抗血栓形成或血栓溶解物质治疗，并且在一些情况下，支架可以并入用于递送的治疗剂。 制造支架的方法包括使用固体颗粒材料形成膜，该固体颗粒材料可以在膜形成之后基本上除去，从而形成上述的凹部和相应的通道。 在优选的方法中，固体颗粒材料可溶于其中膜基本上无力偿还的溶剂。

    Medical device for delivering a therapeutic substance and method therefor
    4.
    发明授权
    Medical device for delivering a therapeutic substance and method therefor 有权
    用于递送治疗物质的医疗装置及其方法

    公开(公告)号：US06399144B2

    公开(公告)日：2002-06-04

    申请号：US09780513

    申请日：2001-02-12

    申请人： Thomas Q. Dinh ,  Rodney G. Wolff ,  Eric P. Berg

    发明人： Thomas Q. Dinh ,  Rodney G. Wolff ,  Eric P. Berg

    IPC分类号： A61L1554

    CPC分类号： A61F2/88 ,  A61F2/86 ,  A61F2250/0067 ,  A61N5/1002

    摘要： A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by contacting an aqueous solution of a therapeutic salt with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The porous material can be made of a polymer other than fibrin with fibrin incorporated into the pores, which can be the only layer of polymeric material on the medical device (e.g., stent). A new method for preparing a porous polymer material on a medical device.

    摘要翻译： 提供了一种可用于局部递送治疗材料的装置。 该装置包括包括多孔材料的结构; 和分散在多孔材料中的治疗材料的水不溶性盐。 通过使治疗盐的水溶液与分散在多孔材料的大部分中的重金属水溶性盐接触而形成水不溶性盐。 多孔材料可以由除了纤维蛋白之外的聚合物制成，纤维蛋白结合到孔中，孔可以是医疗装置（例如，支架）上的唯一的聚合物材料层。 一种用于在医疗装置上制备多孔聚合物材料的新方法。

    Medical device for delivering a therapeutic substance and method therefor
    8.
    发明授权
    Medical device for delivering a therapeutic substance and method therefor 有权

    公开(公告)号：US06187370B1

    公开(公告)日：2001-02-13

    申请号：US09397678

    申请日：1999-09-16

    申请人： Thomas Q. Dinh ,  Rodney G. Wolff ,  Eric P. Berg

    发明人： Thomas Q. Dinh ,  Rodney G. Wolff ,  Eric P. Berg

    IPC分类号： B05D512

    CPC分类号： A61F2/88 ,  A61F2/86 ,  A61F2250/0067 ,  A61N5/1002

    摘要： A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by contacting an aqueous solution of a therapeutic salt with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The porous material can be made of a polymer other than fibrin with fibrin incorporated into the pores, which can be the only layer of polymeric material on the medical device (e.g., stent). A new method for preparing a porous polymer material on a medical device.

    Medical device for delivering a water-insoluble therapeutic salt or substance
    9.
    发明授权
    Medical device for delivering a water-insoluble therapeutic salt or substance 失效
    用于递送水不溶性治疗盐或物质的医疗装置

    公开(公告)号：US6013099A

    公开(公告)日：2000-01-11

    申请号：US69659

    申请日：1998-04-29

    申请人： Thomas Q. Dinh ,  Rodney G. Wolff ,  Eric P. Berg

    发明人： Thomas Q. Dinh ,  Rodney G. Wolff ,  Eric P. Berg

    IPC分类号： A61F2/00 ,  A61F2/86 ,  A61F2/88 ,  A61N5/10 ,  A61F2/06

    CPC分类号： A61F2/88 ,  A61F2/86 ,  A61F2250/0067 ,  A61N5/1002

    摘要： A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by contacting an aqueous solution of a therapeutic salt with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The porous material can be made of a polymer other than fibrin with fibrin incorporated into the pores, which can be the only layer of polymeric material on the medical device (e.g., stent). A new method for preparing a porous polymer material on a medical device.

    摘要翻译： 提供了一种可用于局部递送治疗材料的装置。 该装置包括包括多孔材料的结构; 和分散在多孔材料中的治疗材料的水不溶性盐。 通过使治疗盐的水溶液与分散在多孔材料的大部分中的重金属水溶性盐接触而形成水不溶性盐。 多孔材料可以由除了纤维蛋白之外的聚合物制成，纤维蛋白结合到孔中，孔可以是医疗装置（例如，支架）上的唯一的聚合物材料层。 一种用于在医疗装置上制备多孔聚合物材料的新方法。

    Method for providing a restenosis model in porcine coronary arteries
    10.
    发明授权
    Method for providing a restenosis model in porcine coronary arteries 失效
    在猪冠状动脉中提供再狭窄模型的方法

    公开(公告)号：US5304122A

    公开(公告)日：1994-04-19

    申请号：US981959

    申请日：1992-11-24

    申请人： Robert S. Schwartz ,  Joseph G. Murphy ,  Rodney G. Wolff ,  Vincent W. Hull

    发明人： Robert S. Schwartz ,  Joseph G. Murphy ,  Rodney G. Wolff ,  Vincent W. Hull

    IPC分类号： A61F2/06 ,  A61F2/88 ,  A61M31/00

    CPC分类号： A61F2/88

    摘要： A model of arterial restenosis in domestic pigs using deep injury to the coronary arterial media resulting in extensive proliferative response. Metal wire coils are delivered percutaneously to the coronary arteries of pigs with an oversized, high pressure (14 atm) balloon and left in place for 5-6 weeks. During placement, the balloon expands the coils and delivers them securely within the arterial lumen causing fracture of the internal elastic lamina by the coil. An extensive proliferative response occurs and is associated with a lumenal area narrowing of at least 50% Immunohistochemical studies confirms the prominence of smooth muscle cells in the tissue. The histopathologic features of the proliferative response are identical to those observed in cases of restenosis post-angioplasty.This model closely mimics the proliferative portion of human restenosis both grossly and microscopically. It may thus be useful for understanding human restenosis and for testing therapies aimed at preventing restenosis after balloon angioplasty or other coronary interventional procedures.

    摘要翻译： 家猪的动脉再狭窄模型，对冠状动脉介质使用深度损伤，导致广泛的增殖反应。 将金属丝线经皮经皮递送至具有超大，高压（14atm）气球的猪的冠状动脉，并留在原位5-6周。 在放置期间，气囊扩张线圈并将其牢固地传送到动脉管腔内，从而引起内部弹性层被线圈断裂。 发生广泛的增殖反应并且与至少50％的狭窄区域相关联。免疫组织化学研究证实了组织中平滑肌细胞的突出。 增殖反应的组织病理学特征与在血管成形术后再狭窄情况下观察到的组织病理学特征相同。 该模型严重和微观上模仿人类再狭窄的增殖部分。 因此，可能有助于了解人类再狭窄和用于测试旨在防止气囊血管成形术或其他冠状动脉介入手术后再狭窄的疗法。