公开(公告)号：US20090223460A1

公开(公告)日：2009-09-10

申请号：US12401572

申请日：2009-03-10

申请人： Eric W. Starr ,  Bernard F. Hete

发明人： Eric W. Starr ,  Bernard F. Hete

IPC分类号： A01K1/03

CPC分类号： A01K1/031 ,  A01K1/0613 ,  A61D7/04

摘要： A hypoxia, or other bioactive gas, chamber is provided for use in animal research conducted on non-anesthetized small animals with direct physiologic monitoring.

摘要翻译： 提供缺氧或其他生物活性气体室用于在具有直接生理监测的非麻醉小动物上进行的动物研究。

公开(公告)号：US20120143071A1

公开(公告)日：2012-06-07

申请号：US13156489

申请日：2011-06-09

申请人： Bernard F. Hete ,  Eric J. Ayers ,  Eric W. Starr

发明人： Bernard F. Hete ,  Eric J. Ayers ,  Eric W. Starr

IPC分类号： A61B5/02

CPC分类号： A61B5/02416 ,  A61B5/7257 ,  A61B2503/40

摘要： A noninvasive photoplethysmographic sensor system for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor for mobile animals such as small rodents utilizes multiple FFT's in the processing of the phtotoplethysmograophic signal, where each FFT has a different time record of the signals such as a number of points, or a zero padded FFTs. The noninvasive photoplethysmographic sensor for mobile animals provides actigraphy measurements for the animal.

摘要翻译： 用于诸如小鼠和小鼠之类的移动动物的无创光电体积描记传感器系统是有用的，例如在实验室研究环境中。 用于诸如小型啮齿动物的移动动物的非侵入性光电容积描记传感器在处理噬菌体同位素信号时利用多个FFT，其中每个FFT具有诸如点数或零填充FFT之类的信号的不同时间记录。 用于移动动物的无创光电体积描记传感器为动物提供了动态测量。

公开(公告)号：US07857768B2

公开(公告)日：2010-12-28

申请号：US12249044

申请日：2008-10-10

申请人： Eric W Starr ,  Bernard F. Hete ,  Eric J Ayers

发明人： Eric W Starr ,  Bernard F. Hete ,  Eric J Ayers

IPC分类号： A61B5/0205 ,  A61B5/1455 ,  A61B5/022

CPC分类号： A61B5/02255 ,  A61B5/14552 ,  A61B2503/40

摘要： An integrated tail mounted blood pressure monitor and pulse oximeter system includes a tail blood flow occlusion member configured to selectively occlude blood flow through the tail; a sensor coupled to the tail blood flow occlusion member detecting a degree of operation thereof; Light sources coupled to the tail closer to the distal end of the tail than the tail blood flow occlusion member, and selectively directing light of two different wavelengths into the tail; a light receiver coupled to the tail and selectively receiving a signal associated with light directed into the tail from the light sources; and a controller configured to selectively determine blood pressure parameters from the data and pulse oximeter parameters from the data.

摘要翻译： 综合的尾部安装的血压监测器和脉搏血氧计系统包括构造成选择性地阻塞穿过尾部的血流的尾部血流阻塞构件; 耦合到所述尾部血流阻塞构件的传感器，其检测其操作程度; 耦合到尾部的光源比尾部血流阻塞构件更靠近尾部的远端，并且选择性地将两种不同波长的光引导到尾部中; 耦合到尾部的光接收器并且选择性地接收与从光源引导到尾部中的光相关联的信号; 以及控制器，被配置为从数据中选择性地从数据和脉搏血氧计参数确定血压参数。

公开(公告)号：US20100113902A1

公开(公告)日：2010-05-06

申请号：US12606180

申请日：2009-10-26

申请人： Bernard F. Hete ,  Eric W. Starr ,  Chris Zawada

发明人： Bernard F. Hete ,  Eric W. Starr ,  Chris Zawada

IPC分类号： A61B5/1455 ,  A61B5/055

CPC分类号： G01R33/4808 ,  A61B5/055 ,  A61B5/14552 ,  A61B2503/40

摘要： An efficient, effective, MRI compatible small bore MRI noninvasive photoplethysmographic sensor for animals such as small rodents, namely rats and mice. The photoplethysmographic sensor for animals comprising: a non-magnetic sensor coupling attachable to an animal; fiber optic cable coupled to the sensor coupling and configured to deliver a signal to and receive a signal from the animal tissue adjacent the sensor coupling; an opto-electical converter coupled to the fiber optic cable, the converter including a receiver coupled the fiber optic cable portion configured to receive a signal from the animal tissue and including an emitter coupled to the fiber optic portion configured to deliver a signal to the animal tissue; an electronic coupling extending from the opto-electric converter and configured to be coupled to the emitter and the receiver, wherein the electronic coupling is configured to extend outside of the MRI chamber; and a processor coupled to the electronic coupling.

摘要翻译： 一种高效，有效的MRI兼容小型MRI无创光电体积描记传感器，用于小型啮齿动物，即大鼠和小鼠等动物。 用于动物的光电容积传感器包括：可附接到动物的非磁性传感器耦合器; 光纤电缆耦合到传感器耦合并被配置成将信号传递到邻近传感器耦合器的动物组织并从其接收信号; 耦合到所述光纤电缆的光电转换器，所述转换器包括耦合所述光纤电缆部分的接收器，所述光纤电缆部分被配置为接收来自所述动物组织的信号，并且包括耦合到所述光纤部分的发射器，所述发射器被配置为向所述动物传递信号 组织; 电子耦合器，其从所述光电转换器延伸并且被配置为耦合到所述发射器和所述接收器，其中所述电子耦合器被配置为延伸到所述MRI室外; 以及耦合到电子耦合器的处理器。

公开(公告)号：US08359079B2

公开(公告)日：2013-01-22

申请号：US11858879

申请日：2007-09-20

申请人： Bernard F. Hete ,  Eric W Starr ,  Eric J Ayers

发明人： Bernard F. Hete ,  Eric W Starr ,  Eric J Ayers

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/02416 ,  A61B5/0816 ,  A61B5/7257 ,  A61B5/7278 ,  A61B2503/40

摘要： Medical devices and techniques derive breath rate, breath distention, and pulse distention measurements of a subject from a pulse oximeter system coupled to a subject. These parameters, together with the conventional physiologic parameters obtained from a pulse oximeter system, can be used to assist in controlling the ventilation levels and the anesthesia levels of the subject. The development has human applications and particular applications for animal research.

摘要翻译： 医疗装置和技术从耦合到受试者的脉搏血氧计系统获得受试者的呼吸速率，呼吸膨胀和脉搏扩张测量。 这些参数以及从脉搏血氧计系统获得的常规生理参数可用于帮助控制受试者的通气水平和麻醉水平。 该发展具有人类应用和动物研究的特殊应用。

公开(公告)号：US20120004517A1

公开(公告)日：2012-01-05

申请号：US12980324

申请日：2010-12-28

申请人： Eric W. Starr ,  Bernard F. Hete

发明人： Eric W. Starr ,  Bernard F. Hete

IPC分类号： A61B5/02 ,  A61B5/1455 ,  A61B5/022

CPC分类号： A61B5/02255 ,  A61B5/14552 ,  A61B2503/40

摘要： An integrated blood pressure monitor and pulse oximeter system includes a blood flow occlusion member configured to selectively occlude blood flow through an appendage of the animal (e.g., the neck or tail); a sensor coupled to the blood flow occlusion member detecting a degree of operation thereof; Light sources coupled to the tail closer to the distal end of the tail than the tail blood flow occlusion member, and selectively directing light of two different wavelengths into the appendage; a light receiver coupled to the appendage and selectively receiving a signal associated with light directed into the appendage from the light sources; and a controller configured to selectively determine blood pressure parameters from the data and pulse oximeter parameters from the data.

摘要翻译： 综合血压监测器和脉搏血氧计系统包括血液阻塞构件，其构造成选择性地阻塞通过动物的附肢（例如颈部或尾部）的血流; 耦合到所述血流阻塞构件的传感器，其检测其操作程度; 耦合到尾部的光源比尾部血流阻塞构件更靠近尾部远端，并且将两种不同波长的光选择性地引导到附属物中; 耦合到附件的光接收器并且选择性地接收与从光源引导到附属物中的光相关联的信号; 以及控制器，被配置为从数据中选择性地从数据和脉搏血氧计参数确定血压参数。

公开(公告)号：US20110137185A1

公开(公告)日：2011-06-09

申请号：US12785421

申请日：2010-05-21

申请人： Bernard F. Hete ,  Eric W. Starr

发明人： Bernard F. Hete ,  Eric W. Starr

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61B5/14552 ,  A61B5/6826 ,  A61B2503/40

摘要： A noninvasive photoplethysmographic sensor platform for small animals provides a spring biased sensor clip, wherein at least one side of the sensor clip is provided with a saddle faced clip face member. The saddle shape of the clip face member may have a hinge end, toward the hinge of the clip, which is longer in the longitudinal direction of the clip and shorter in depth than the distal end. The shorter distal end side (measured longitudinally) of this saddle shape facilitates the ability to align the transmitted and received light with the bone, while the overall saddle shape of the facing provides a physical grip to capture enough tissue to prevent the clip from relocating over time while it is attached to the limb. The shorter hinge end side (depth-wise) also allows the clip to close when it is fully assembled. The edges of the saddle shaped clip are preferably rounded off to prevent the contusions of the tissue that may result from long-term contact. This saddle faced feature works well on only one side of the clip.

摘要翻译： 用于小动物的非侵入式光电容积传感器平台提供弹簧偏置传感器夹，其中传感器夹的至少一侧设置有鞍形面夹具构件。 夹面构件的鞍座形状可以具有朝向夹子的铰链的铰链端，其在夹子的纵向方向上较长并且比远端更深。 这种马鞍形状的较短的远端侧（纵向测量）有助于将透射和接收的光与骨骼对准的能力，而面部的整体鞍座形状提供物理抓地力以捕获足够的组织以防止夹子重新定位在 时间，而它附加到肢体。 较短的铰链端侧（深度方向）也允许夹子完全组装后关闭。 鞍状夹子的边缘优选地倒圆，以防止长期接触可能引起的组织挫伤。 这个马鞍面对的功能只能在剪辑的一侧工作。

公开(公告)号：US07922666B2

公开(公告)日：2011-04-12

申请号：US11858881

申请日：2007-09-20

申请人： Eric W Starr ,  Eric J Ayers ,  Bernard F. Hete

发明人： Eric W Starr ,  Eric J Ayers ,  Bernard F. Hete

IPC分类号： A61B5/0205 ,  A61B5/1455 ,  A61B5/024

CPC分类号： A61B5/02007 ,  A61B5/0205 ,  A61B5/0816 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/4821 ,  A61B5/7257 ,  A61B5/746 ,  A61B2503/40 ,  A61M16/0051 ,  A61M16/01 ,  A61M16/024

摘要： Medical devices and techniques derive breath rate, breath distention, and pulse distention measurements of a subject from a pulse oximeter system coupled to the subject. These parameters together with the conventional physiologic parameters obtained from a pulse oximeter system can be used to assist in controlling the ventilation levels and the anesthesia levels of the subject. The development has human applications and particular application for animal research.

摘要翻译： 医疗装置和技术从耦合到受试者的脉搏血氧计系统获得受试者的呼吸速率，呼吸膨胀和脉搏扩张测量。 这些参数与从脉搏血氧计系统获得的常规生理参数一起可用于帮助控制受试者的通气水平和麻醉水平。 该发展具有人类应用和动物研究的特殊应用。

公开(公告)号：US08688184B2

公开(公告)日：2014-04-01

申请号：US12330501

申请日：2008-12-08

申请人： Patrick Truitt ,  Bernard F. Hete ,  Eric W Starr

发明人： Patrick Truitt ,  Bernard F. Hete ,  Eric W Starr

IPC分类号： A61B5/00

CPC分类号： A61B5/14552 ,  A61B2503/40

摘要： A noninvasive photoplethysmographic sensor platform for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor platform may be a collar which provides an easily affixed, adjustable attachment mechanism that encircles the animal, such as the neck. The neck of the animal provides several particular advantages as a sensor mounting platform for photoplethysmographic sensors. For pulse oximetry, the neck location will provide significant blood flow under all conditions. For small mammals, such as rats and mice, transmittance pulse oximetry through the neck of the subject remains possible. The neck mounted collar also offers inherent bite resistance to the sensor platform.

摘要翻译： 用于诸如小鼠和小鼠的移动动物的无创光电体积描记传感器平台是有用的，例如在实验室研究环境中。 无创光电体积描记传感器平台可以是一个套环，提供一个环绕动物（如颈部）的容易固定的可调节的附接机构。 作为光电容积传感器的传感器安装平台，动物的颈部提供了几个特殊的优点。 对于脉搏血氧饱和度测量，颈部位置将在所有条件下提供显着的血流量。 对于小型哺乳动物，如大鼠和小鼠，穿过受试者颈部的透射脉搏血氧饱和度仍然是可能的。 颈部安装的衣领还为传感器平台提供了固有的抗咬伤性。

公开(公告)号：US20100160751A1

公开(公告)日：2010-06-24

申请号：US12704024

申请日：2010-02-11

申请人： Bernard F. Hete ,  Eric W. Starr ,  Eric J. Ayers

发明人： Bernard F. Hete ,  Eric W. Starr ,  Eric J. Ayers

IPC分类号： A61B5/1455

CPC分类号： G01N33/4925 ,  A61B5/14557

摘要： A blood oxygenation monitoring device may comprise an extracorporeal pulse simulation system including one at least partially transparent blood holding element with a photoplethysmographic sensor coupled to the element and adapted to measure particular gas content of the blood. The system includes a pulse simulation mechanism configured to simulate pulsatile behavior of the blood within the element relative to the photoplethysmographic sensors. The blood holding element may be a reservoir, wherein the pulse simulation mechanism includes a magnetic stirrer and stir bar within the reservoir. The blood holding member may be flexible tubing having blood flow there through, wherein the pulse simulation mechanism is a peristaltic pump coupled to the tubing. The monitoring device can rapidly and accurately form oxygen dissociation curves. The monitoring device can be utilized in conjunction with a heart lung bypass machine or other extra corporeal circuit devices or can be a calibration tool for sensors.

摘要翻译： 血氧监测装置可以包括体外脉冲模拟系统，其包括一个至少部分透明的血液保持元件，其具有耦合到该元件的光电容积传感器传感器，并且适于测量血液的特定气体含量。 该系统包括脉冲模拟机构，其被配置为模拟元件内相对于光电容积传感器的血液的脉动行为。 血液保持元件可以是储存器，其中脉冲模拟机构包括储存器内的磁力搅拌器和搅拌棒。 血液保持构件可以是具有血液流过的柔性管，其中脉冲模拟机构是联接到管道的蠕动泵。 监测装置可以快速准确地形成氧解离曲线。 监测装置可以与心脏肺旁路机或其他额外的物理电路装置结合使用，或者可以是用于传感器的校准工具。