公开(公告)号：US08989867B2

公开(公告)日：2015-03-24

申请号：US13434119

申请日：2012-03-29

申请人： Eric Y. Chow ,  Milton M. Morris ,  David L. Thompson

发明人： Eric Y. Chow ,  Milton M. Morris ,  David L. Thompson

IPC分类号： A61N1/00 ,  A61N1/378 ,  A61N1/36

CPC分类号： A61N1/3787 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/3605 ,  A61N1/37211 ,  A61N1/37223

摘要： A particular implantable device may include an antenna configured to receive a far field radiative signal. The implantable device may also include a voltage rectifier configured to rectify the far field radiative signal received by the antenna to provide a rectified voltage signal. The implantable device may further include a charge storage element operative to receive the rectified voltage signal and to store charge responsive to the rectified voltage signal. The implantable device may also include a stimulation module powered by the charge storage element. The stimulation module may be operative to generate an electrical stimulation signal to stimulate a target nerve of a patient. The implantable medical device may further include a nerve wrap configured to house the voltage rectifier, the charge storage element, and the stimulation module. The nerve wrap may include one or more electrodes operative to deliver the electrical stimulation signal to the target nerve.

摘要翻译： 特定的可植入装置可以包括被配置为接收远场辐射信号的天线。 可植入装置还可以包括电压整流器，其被配置为对由天线接收的远场辐射信号进行整流以提供整流的电压信号。 可植入装置还可以包括电荷存储元件，其可操作以接收经整流的电压信号并且响应于整流电压信号来存储电荷。 可植入装置还可以包括由电荷存储元件供电的刺激模块。 刺激模块可操作以产生电刺激信号以刺激患者的目标神经。 可植入医疗装置还可以包括构造成容纳电压整流器，电荷存储元件和刺激模块的神经包裹物。 神经包裹可以包括一个或多个电极，其可操作以将电刺激信号递送到目标神经。

公开(公告)号：US20180085593A1

公开(公告)日：2018-03-29

申请号：US15830862

申请日：2017-12-04

申请人： Timothy A. Fayram ,  Alexander Yeh ,  Gary Shaw ,  Randolph Kerry Armstrong ,  Milton M. Morris ,  Elia Junco ,  Brad Holinski

发明人： Timothy A. Fayram ,  Alexander Yeh ,  Gary Shaw ,  Randolph Kerry Armstrong ,  Milton M. Morris ,  Elia Junco ,  Brad Holinski

IPC分类号： A61N1/372 ,  A61N1/378 ,  A61N1/375

CPC分类号： A61N1/36062 ,  A61B5/00 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/36185 ,  A61N1/37223 ,  A61N1/37229 ,  A61N1/37247 ,  A61N1/37252 ,  A61N1/37518 ,  A61N1/3756 ,  A61N1/3787 ,  H02J7/025 ,  H02J50/10 ,  H02J50/20 ,  H02J50/40 ,  H02J50/80 ,  H02J50/90

摘要： Generally discussed herein are systems, devices, and methods for providing a therapy (e.g., stimulation) and/or data signal using an implantable device. Systems, devices and methods for interacting with (e.g., communicating with, receiving power from) an external device are also provided.

公开(公告)号：US07894892B2

公开(公告)日：2011-02-22

申请号：US12254567

申请日：2008-10-20

申请人： Milton M. Morris

发明人： Milton M. Morris

IPC分类号： A61N1/365

CPC分类号： A61N1/3621 ,  A61N1/3962

摘要： An implantable heart-monitoring device comprising one or more leads for sensing electrical signals of a patient's heart a therapy circuit for delivering pharmaceuticals to the patient; and a monitoring circuit coupled to the one or more leads and to the therapy circuit, the monitoring circuit for monitoring heart activity of the patient through one or more of the leads, the monitoring circuit operable to: determine a minimum interval from a set of two or more intervals based on sensed heart activity, determine a range parameter based on a difference between a first subset and second subset of the intervals, determine a dispersion parameter quantifying dispersion of a subset of the intervals, and to determine an assessment value for the set of intervals, based on the minimum interval, the range parameter, the dispersion index.

摘要翻译： 一种可植入心脏监测装置，包括用于感测患者心脏的电信号的一个或多个引线，用于将药物输送给患者的治疗电路; 以及监测电路，其耦合到所述一个或多个引线和所述治疗电路，所述监测电路用于通过一个或多个引线监测患者的心脏活动，所述监测电路可操作以：从两组中的一组确定最小间隔 基于感测到的心脏活动的更多间隔，基于间隔的第一子集和第二子集之间的差确定范围参数，确定量化间隔子集的色散的色散参数，并且确定该组的评估值 基于最小间隔，范围参数，色散指数。

公开(公告)号：US20100305639A1

公开(公告)日：2010-12-02

申请号：US12836784

申请日：2010-07-15

申请人： Victor T. Chen ,  David S. Wood ,  Milton M. Morris

发明人： Victor T. Chen ,  David S. Wood ,  Milton M. Morris

IPC分类号： A61N1/365 ,  A61N1/368

CPC分类号： A61N1/3622

摘要： A system and method which employs atrial discrimination algorithms to distinguish between different atrial arrhythmias occurring in a patient for selecting an optimal pacing therapy corresponding to the type of arrhythmia identified. In response to the detection of an atrial rate above the atrial tracking rate, discrimination criteria are applied to a detected atrial activity signal to distinguish between different types of supraventricular tachycardia, such as fast atrial flutter and other atrial flutter at a relatively slower rate, which may be occurring in the patient. The pacer is controlled to provide pacing therapy to a heart in a manner corresponding to the type of supraventricular tachycardia identified. The output of an atrial discrimination algorithm may be tracked and the trend thereof used to improve therapy timing. Various embodiments are disclosed herein.

摘要翻译： 一种使用心房辨别算法来区分患者发生的不同心房心律不齐的系统和方法，用于选择对应于确定的心律失常类型的最佳起搏治疗。 响应于心房率高于心房跟踪率的检测，将鉴别标准应用于检测到的心房活动信号，以区别不同类型的室上性心动过速，例如以较慢速率的快速心房扑动和其他心房扑动，其中 可能发生在患者身上。 控制起搏器以对应于所鉴定的室上性心动过速类型的方式向心脏提供起搏治疗。 可以跟踪心房辨别算法的输出，并且其趋势用于改善治疗时机。 本文公开了各种实施例。

公开(公告)号：US20080319494A1

公开(公告)日：2008-12-25

申请号：US12229563

申请日：2008-08-25

申请人： Victor T. Chen ,  Gary T. Seim ,  Milton M. Morris

发明人： Victor T. Chen ,  Gary T. Seim ,  Milton M. Morris

IPC分类号： A61N1/362

CPC分类号： A61N1/3962 ,  A61N1/3622

摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.

摘要翻译： 用于在心脏复律/除颤休克之后提供起搏脉冲的系统和方法，其中起搏脉冲具有初始值的起搏速率。 起搏速率从初始值降低到检测到至少一个固有心脏收缩。 在一个实施例中，起搏速率在起搏设定数量的心动周期后降低设定量。 然后重复提供设定数量的起搏脉冲并将起搏速率降低设定量，直到检测到至少一个固有心脏收缩。 然后从至少一个固有心脏收缩确定固有心率。 然后起搏速率增加并保持在高于（即大于）本征心率。

公开(公告)号：US08538519B2

公开(公告)日：2013-09-17

申请号：US11113827

申请日：2005-04-25

申请人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

发明人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

IPC分类号： A61N1/365

CPC分类号： A61N1/36528 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A system and method for identifying patients with asynchronous ventricular contractions due to abnormal electro-mechanical coupling and computing optimal pacing parameters for restoring synchronous contractions is disclosed. Such patients may have normal intra-ventricular and inter-ventricular conduction and cannot be identified from intrinsic conduction data alone such as QRS width. Techniques for computing optimal resynchronization pacing in order to compensate for abnormal electro-mechanical coupling are also described.

摘要翻译： 公开了一种用于识别异常心电耦合异常心室收缩患者的系统和方法，并且计算用于恢复同步收缩的最佳起搏参数。 这样的患者可能具有正常的心室内和心室间传导，并且不能从内在传导数据单独识别，如QRS宽度。 还描述了用于计算最佳再同步起搏以补偿异常机电耦合的技术。

公开(公告)号：US06973348B2

公开(公告)日：2005-12-06

申请号：US10292415

申请日：2002-11-11

申请人： Milton M. Morris

发明人： Milton M. Morris

IPC分类号： A61B5/04 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61B5/04012 ,  A61N1/3621 ,  A61N1/365

摘要： Thousands of patients prone to irregular and sometimes life threatening heart rhythms have miniature heart-monitoring devices, such as defibrillators and cardioverters, implanted in their chests. These devices detect abnormal heart rhythms and automatically apply electrical therapy to restore normal heart function. Significant parts of these devices include the microprocessor and stored instructions, or algorithms, that govern how the devices interpret and react to electrical signals indicative of normal or abnormal heart rhythms. These algorithms generally use the time intervals between successive heart beats, or cardiac events, as a key factor in therapy decisions. To ensure accuracy of interval measurements, the inventor devised new methods for processing heart electrical signals, some of which ensure accurate interval measurements without unduly delaying therapy decisions or consuming significant battery power. One of these new methods detects an abnormal interval measurement and either disqualifies the abnormal interval from use in making therapy decisions or divides the abnormal interval into two or more other intervals, thereby facilitating identification and treatment of abnormal rhythmic conditions both efficiently and accurately.

摘要翻译： 容易出现不规则，有时威胁生命的心脏节律的成千上万的患者将微型心脏监测装置（如除颤器和心脏复律器）植入胸部。 这些装置检测异常的心律，并自动应用电疗法恢复正常的心脏功能。 这些设备的重要部分包括微处理器和存储的指令或算法，其指导设备如何解释和反应指示正常或异常心律的电信号。 这些算法通常将连续心跳或心脏事件之间的时间间隔用作治疗决策的关键因素。 为了确保间隔测量的准确性，本发明人设计了用于处理心脏电信号的新方法，其中一些确保准确的间隔测量，而不会不适当地延迟治疗决定或消耗显着的电池电量。 这些新方法中的一种检测异常间隔测量，并且取消在作出治疗决定时使用的异常间隔的资格，或将异常间隔划分为两个或更多个其他间隔，从而有效和准确地识别和治疗异常节律条件。

公开(公告)号：US06681134B2

公开(公告)日：2004-01-20

申请号：US09955491

申请日：2001-09-18

申请人： Milton M. Morris

发明人： Milton M. Morris

IPC分类号： A61N1365

CPC分类号： A61N1/3621 ,  A61N1/3962

摘要： Thousands of patients prone to irregular and sometimes life threatening heart rhythms have miniature heart-monitoring devices, such as defibrillators and cardioverters, implanted in their chests. These devices detect onset of abnormal heart rhythms and automatically apply one or more shocks to their hearts. When properly sized and timed, the shocks restore normal heart function without human intervention. A critical part of these devices is the monitoring circuitry, which includes a microprocessor and stored instructions, or algorithms, that govern how the devices interpret and react to electrical signals indicative of abnormal heart rhythms. Often, the algorithms are too simple or too complex. Algorithms that are too simple lead to unnecessary shocking of the heart, while those that are too complex consume considerable battery power. Accordingly, the inventor devised a relatively simple and accurate algorithm for determining appropriate therapy options. One version of the algorithm computes three statistics—a range statistic, a minimum interval statistic, and a dispersion index—from a set of depolarization intervals. This algorithm defines the range statistic as the difference between largest and smallest depolarization intervals, the minimum interval as the smallest of the intervals, and the dispersion index as the standard deviation of the intervals. A scalar interval dispersion assessment, based on the three statistics, is then compared to a threshold to identify a rhythm as a flutter or fibrillation. The three statistics can also define a point in a three-dimensional space, with rhythm identification based on relative position of the point and a surface in the space.

摘要翻译： 容易出现不规则，有时威胁生命的心脏节律的成千上万的患者将微型心脏监测装置（如除颤器和心脏复律器）植入胸部。 这些装置检测出异常心律的发作，并自动对其心脏施加一次或多次冲击。 正确的尺寸和时间，震荡恢复正常的心脏功能，无需人为干预。 这些设备的关键部分是监控电路，其包括微处理器和存储的指令或算法，其控制设备如何解释和反应指示异常心律的电信号。 通常，算法太简单或太复杂。 太简单的算法会导致心脏不必要的震动，而那些太复杂的算法会消耗大量的电池电量。 因此，发明人设计了一种相对简单和准确的算法来确定适当的治疗方案。 一个版本的算法从一组去极化间隔计算三个统计量 - 范围统计量，最小间隔统计量和色散指数。 该算法将范围统计量定义为最大和最小去极化间隔之间的差异，间隔的最小间隔，以及作为间隔的标准偏差的色散指数。 然后将基于三个统计量的标量间隔色散评估与阈值进行比较，以将节律识别为颤动或颤动。 三个统计数据还可以在三维空间中定义一个点，其中基于点的相对位置和空间中的表面的节奏识别。

公开(公告)号：US06666862B2

公开(公告)日：2003-12-23

申请号：US09797435

申请日：2001-03-01

申请人： Mudit K. Jain ,  Milton M. Morris ,  Bruce KenKnight

发明人： Mudit K. Jain ,  Milton M. Morris ,  Bruce KenKnight

IPC分类号： A61B1818

CPC分类号： A61B18/1492 ,  A61B18/16 ,  A61B2018/0016 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00714 ,  A61B2018/00726 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00839 ,  A61B2018/00863 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/1273 ,  A61B2018/1286 ,  A61B2018/1467 ,  A61B2090/065

摘要： Information indicative of the flow rate of fluid through a biological organ is provided to a processor. Using this information the processor assesses whether the fluid-flow rate is high or low and controls a generator such that the generator provides energy to an electrode positioned within the organ to effect tissue ablation. Energy of a first level is provided during periods of high fluid-flow and energy of a second level, less than the first level, during periods of low fluid-flow. The flow rate information may be provided by an electrocardiograph (ECG) device or a flow sensor. A temperature sensor provides temperature signals to the processor indicative of the electrode temperature. The processor further controls the generator based on the electrode temperature to maintain the temperature at or near a target temperature and below a maximum threshold temperature.

公开(公告)号：US5797399A

公开(公告)日：1998-08-25

申请号：US639859

申请日：1996-04-19

申请人： Milton M. Morris ,  Janice M. Jenkins ,  Lorenzo A. DiCarlo

发明人： Milton M. Morris ,  Janice M. Jenkins ,  Lorenzo A. DiCarlo

IPC分类号： A61B5/046 ,  A61N1/39 ,  A61B5/0402

CPC分类号： A61B5/7264 ,  A61B5/046 ,  A61N1/3956 ,  Y10S128/92

摘要： A pattern recognition system for use in an implantable cardioverter defibrillator that is capable of responding correctively to abnormal activity of the heart efficiently and specifically. The system of the present invention first establishes a template standard defining a median or other statistical measure of central tendency representing the point above which or below which actual sample values would be remarkable. Against the median are compared sampled values within a window having a pre-programmed length. For each cycle, a comparison is made between the template median and every value sampled within this pre-programmed window. Each cycle is then individually diagnosed such that if a selected value is above a particular pre-established threshold or below a particular pre-established threshold it will be classified as abnormal. A plurality of specific cycles must be classified abnormal in order for a final diagnosis to be made that the individual is experiencing arrhythmia. The system of the present invention is also capable of differentiating between types of abnormal and can classify the abnormal as being either ventricular tachycardia and ventricular fibrillation.

摘要翻译： 一种用于植入式心律转复除颤器中的模式识别系统，其能够有效且具体地对心脏的异常活动进行正确的响应。 本发明的系统首先建立了模板标准，其定义了中心趋势的中位趋势或其他统计量度，该中心倾向表示高于该点或低于哪个实际样本值是显着的点。 对于中值，在具有预编程长度的窗口内比较采样值。 对于每个周期，在模板中位数和在此预编程窗口中采样的每个值之间进行比较。 然后单独诊断每个周期，使得如果所选择的值高于特定的预先建立的阈值或低于特定的预先建立的阈值，则将被分类为异常。 必须将多个特定周期分类为异常，以便进行最终诊断以证明个体正在经历心律失常。 本发明的系统还能够区分异常的类型，并且可以将异常分类为室性心动过速和心室颤动。