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    Fiber optic based detection of autofluorescent bacterial pathogens
    2.
    发明授权
    Fiber optic based detection of autofluorescent bacterial pathogens 有权
    光纤检测自身荧光细菌病原体

    公开(公告)号：US08280471B2

    公开(公告)日：2012-10-02

    申请号：US11954867

    申请日：2007-12-12

    申请人： Mike Rainone ,  Erica M. Phillips ,  Richard Hantke ,  Shawn R. Feaster ,  Daniel Baird ,  Thomas Edward Plowman ,  Talbot Presley

    发明人： Mike Rainone ,  Erica M. Phillips ,  Richard Hantke ,  Shawn R. Feaster ,  Daniel Baird ,  Thomas Edward Plowman ,  Talbot Presley

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/0059 ,  A61B5/445 ,  G01N21/6486 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/129

    摘要： Disclosed are methods and devices for continuous in vivo monitoring of a potential bacterial infection site. Disclosed devices may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of a hospital acquired infection, thereby providing for earlier intervention. Disclosed methods utilize optical fibers to deliver an excitation signal to an area in which pathogenic bacteria may exist. In the presence of the excitation signal, bacterial pathogens may autofluoresce with a unique spectral signature. Upon generation of a fluorescent emission, an optically detectable emission signal may be transmitted to a detection/analysis device. Analysis of the characteristics of the emission signal produced in response to the excitation signal may be used to determine the presence or concentration of pathogens at the site of inquiry, following which real time information may be transmitted to medical personnel via a wireless transmission system.

    摘要翻译： 公开了用于连续体内监测潜在细菌感染部位的方法和装置。 可以利用公开的装置来在医院获得性感染的早期阶段向患者和/或保健提供者警告病原菌的存在，从而提供早期干预。 公开的方法利用光纤将激发信号传递到可能存在病原菌的区域。 在激发信号的存在下，细菌病原体可以自发荧光具有独特的光谱特征。 在产生荧光发射时，光学上可检测的发射信号可被传送到检测/分析装置。 对响应于激发信号产生的发射信号的特性的分析可以用于确定在询问现场的病原体的存在或集中，随后可以通过无线传输系统向医务人员传送实时信息。

    FIBER OPTIC BASED DETECTION OF AUTOFLUORESCENT BACTERIAL PATHOGENS
    3.
    发明申请
    FIBER OPTIC BASED DETECTION OF AUTOFLUORESCENT BACTERIAL PATHOGENS 有权
    光纤光学检测自动细菌病原体

    公开(公告)号：US20090156943A1

    公开(公告)日：2009-06-18

    申请号：US11954867

    申请日：2007-12-12

    申请人： Erica M. Phillips ,  Daniel Baird ,  Richard Hantke ,  Shawn R. Feaster ,  Mike Rainone ,  Thomas Edward Plowman ,  Talbot Presley

    发明人： Erica M. Phillips ,  Daniel Baird ,  Richard Hantke ,  Shawn R. Feaster ,  Mike Rainone ,  Thomas Edward Plowman ,  Talbot Presley

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/445 ,  G01N21/6486 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/129

    摘要： Disclosed are methods and devices for continuous in vivo monitoring of a potential bacterial infection site. Disclosed devices may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of a hospital acquired infection, thereby providing for earlier intervention and improved recovery rates from bacterial infection. Disclosed methods utilize optical fibers to deliver an excitation signal to an area in which pathogenic bacteria may exist. In the presence of the excitation signal, bacterial pathogens may autofluoresce with a unique spectral signature. Upon generation of a fluorescent emission, an optically detectable emission signal may be transmitted to a detection/analysis device. Analysis of the characteristics of the emission signal produced in response to the excitation signal may be used to determine the presence or concentration of pathogens at the site of inquiry, following which real time information may be transmitted to medical personnel via a wireless transmission system.

    摘要翻译： 公开了用于连续体内监测潜在细菌感染部位的方法和装置。 可以利用公开的装置在医院获得性感染的早期阶段向患者和/或保健提供者警告病原菌的存在，从而提供早期干预并提高细菌感染的恢复率。 公开的方法利用光纤将激发信号传递到可能存在病原菌的区域。 在激发信号的存在下，细菌病原体可以自发荧光具有独特的光谱特征。 在产生荧光发射时，光学上可检测的发射信号可被传送到检测/分析装置。 对响应于激发信号产生的发射信号的特性的分析可以用于确定在询问现场的病原体的存在或浓度，随后可以通过无线传输系统向医务人员传送实时信息。

    Recombinant Bacteriophage for Detection of Nosocomial Infection
    4.
    发明申请
    Recombinant Bacteriophage for Detection of Nosocomial Infection 有权
    重组噬菌体检测医院感染

    公开(公告)号：US20120143024A1

    公开(公告)日：2012-06-07

    申请号：US11955779

    申请日：2007-12-13

    申请人： Erica M. Phillips ,  Richard Hantke ,  Daniel Baird ,  Mike Rainone ,  Thomas Edward Plowman ,  Talbot Presley

    发明人： Erica M. Phillips ,  Richard Hantke ,  Daniel Baird ,  Mike Rainone ,  Thomas Edward Plowman ,  Talbot Presley

    IPC分类号： A61B5/1455

    CPC分类号： G01N21/7703 ,  A61B5/0071 ,  A61K49/0013 ,  A61K49/0047 ,  A61K49/0097 ,  C12Q1/04 ,  G01N2021/7786 ,  G01N2021/7796

    摘要： Disclosed herein are methods and devices for detection of bacterial HAI. Disclosed methods may be utilized for continuous in vivo monitoring of a potential bacterial infection site and may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of infection. Disclosed methods include utilization of recombinant bacteriophage to deliver to pathogenic bacteria a translatable genetic sequence encoding an optically detectable marker or an enzyme capable of producing an optically detectable marker. Upon detection of the optical signal produced by the marker, medical personnel may be alerted to the presence of pathogenic bacteria at the site of inquiry. Any bacterial causative agent of HAI may be detected according to disclosed methods.

    摘要翻译： 本文公开了用于检测细菌HAI的方法和装置。 公开的方法可以用于潜在细菌感染部位的连续体内监测，并且可以用于在感染的早期阶段向病人和/或保健提供者报告病原菌的存在。 所公开的方法包括利用重组噬菌体将致病细菌递送至编码光学可检测标记或能产生光学可检测标记物的酶的可翻译遗传序列。 在检测到由标记物产生的光信号时，医务人员可以在询问现场警告病原菌的存在。 可以根据公开的方法检测HAI的任何细菌致病因子。

    Recombinant bacteriophage for detection of nosocomial infection
    5.
    发明授权
    Recombinant bacteriophage for detection of nosocomial infection 有权
    用于检测医院感染的重组噬菌体

    公开(公告)号：US08619257B2

    公开(公告)日：2013-12-31

    申请号：US11955779

    申请日：2007-12-13

    申请人： Thomas Edward Plowman ,  Erica M. Phillips ,  Richard Hantke ,  Daniel Baird ,  Mike Rainone ,  Talbot Presley

    发明人： Thomas Edward Plowman ,  Erica M. Phillips ,  Richard Hantke ,  Daniel Baird ,  Mike Rainone ,  Talbot Presley

    IPC分类号： G01N21/00 ,  G01N33/48

    CPC分类号： G01N21/7703 ,  A61B5/0071 ,  A61K49/0013 ,  A61K49/0047 ,  A61K49/0097 ,  C12Q1/04 ,  G01N2021/7786 ,  G01N2021/7796

    摘要： Disclosed herein are methods and devices for detection of bacterial HAI. Disclosed methods may be utilized for continuous in vivo monitoring of a potential bacterial infection site and may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of infection. Disclosed methods include utilization of recombinant bacteriophage to deliver to pathogenic bacteria a translatable genetic sequence encoding an optically detectable marker or an enzyme capable of producing an optically detectable marker. Upon detection of the optical signal produced by the marker, medical personnel may be alerted to the presence of pathogenic bacteria at the site of inquiry. Any bacterial causative agent of HAI may be detected according to disclosed methods.

    摘要翻译： 本文公开了用于检测细菌HAI的方法和装置。 公开的方法可以用于潜在细菌感染部位的连续体内监测，并且可以用于在感染的早期阶段向病人和/或保健提供者报告病原菌的存在。 所公开的方法包括利用重组噬菌体将致病细菌递送至编码光学可检测标记或能产生光学可检测标记物的酶的可翻译遗传序列。 在检测到由标记物产生的光信号时，医务人员可以在询问现场警告病原菌的存在。 可以根据公开的方法检测HAI的任何细菌致病因子。

    Resonance Energy Transfer Based Detection of Nosocomial Infection
    6.
    发明申请
    Resonance Energy Transfer Based Detection of Nosocomial Infection 有权
    共振能量转移检测医院感染

    公开(公告)号：US20090156942A1

    公开(公告)日：2009-06-18

    申请号：US11954848

    申请日：2007-12-12

    申请人： Erica M. Phillips ,  Richard Hantke ,  Daniel Baird ,  Mike Rainone ,  Thomas Edward Plowman ,  Talbot Presley

    发明人： Erica M. Phillips ,  Richard Hantke ,  Daniel Baird ,  Mike Rainone ,  Thomas Edward Plowman ,  Talbot Presley

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/445 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/66 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/7703 ,  G01N2021/6441 ,  G01N2021/7716 ,  G01N2021/772 ,  G01N2021/773 ,  G01N2201/0221

    摘要： Disclosed herein are methods and devices for detection of hospital acquired infections. Disclosed methods may be utilized for continuous in vivo monitoring of a potential infection site or for periodic in vitro monitoring of tissue or fluid from a patient and may be utilized to alert patients and/or health care providers to the presence of a pathogen at an early stage of infection. Disclosed methods utilize fluorophore pairs that optically interact with one another according to Forster resonance energy transfer (FRET) or bioluminescence resonance energy transfer (BRET) mechanism. One member of the pair or a cofactor that interacts with an enzyme to form a member of the pair may be tethered to a device by a substrate that is specific for an enzyme expressed by a targeted pathogen. Upon interaction of the enzyme with the substrate, an optically detectable signal may be altered or initiated, detection of which may then provide information as to the existence of the pathogen at the site.

    摘要翻译： 本文公开了用于检测医院获得性感染的方法和装置。 公开的方法可以用于潜在感染部位的连续体内监测或用于周期性体外监测来自患者的组织或液体，并且可以用于早期警告患者和/或保健提供者病原体的存在 感染阶段 公开的方法利用根据福斯特共振能量转移（FRET）或生物发光共振能量转移（BRET）机制彼此光学相互作用的荧光团对。 该对中的一个成员或与酶相互作用以形成该对成员的辅因子可以通过对由靶向病原体表达的酶特异性的底物连接到装置上。 当酶与底物相互作用时，可以改变或开始光学可检测的信号，其检测可随后提供关于该位点病原体存在的信息。

    FIELD EFFECT TRANSISTORS FOR DETECTION OF NOSOCOMIAL INFECTION
    7.
    发明申请
    FIELD EFFECT TRANSISTORS FOR DETECTION OF NOSOCOMIAL INFECTION 审中-公开
    用于检测NOSOCOMIAL感染的场效应晶体管

    公开(公告)号：US20120143027A1

    公开(公告)日：2012-06-07

    申请号：US11959823

    申请日：2007-12-19

    申请人： Erica M. Phillips ,  Richard Hantke ,  Daniel Baird ,  Mike Rainone ,  Thomas Edward Plowman ,  Talbot Presley

    发明人： Erica M. Phillips ,  Richard Hantke ,  Daniel Baird ,  Mike Rainone ,  Thomas Edward Plowman ,  Talbot Presley

    IPC分类号： A61B5/1473

    CPC分类号： G01N27/4145

    摘要： Disclosed herein are methods and devices for detection of hospital acquired infections. Disclosed methods may be utilized for continuous in vivo monitoring of a potential infection site and may be utilized to alert patients and/or health care providers to changes in the local environment due to the presence of a pathogen at an early stage of infection. Disclosed methods utilize ion sensitive field effect transistors (ISFETs) to detect changes in ionic concentration at the site due to the presence of a pathogen, for instance at a surgical site. When a pathogen is present, the local ionic concentration, and hence the electrical characteristics of an ISFET may change, causing a detectable signal from the ISFET. An ISFET may be associated with a biological material such as an enzyme or a specific binding partner for an expression product of a pathogen to improve detection. Upon interaction of the expression product with the enzyme or the probe, the electrical characteristics of the ISFET may change, detection of which may then provide information as to the existence a pathogen at the site.

    摘要翻译： 本文公开了用于检测医院获得性感染的方法和装置。 公开的方法可以用于潜在感染部位的连续体内监测，并且可以用于警告患者和/或保健提供者由于感染早期存在病原体而导致局部环境的变化。 公开的方法利用离子敏感场效应晶体管（ISFET）来检测由于存在病原体而导致的位置处离子浓度的变化，例如在外科手术部位。 当存在病原体时，ISFET的局部离子浓度以及因此的电特性可能会改变，导致来自ISFET的可检测信号。 ISFET可以与生物材料例如病原体的表达产物的酶或特异性结合配偶体相关联，以改善检测。 当表达产物与酶或探针相互作用时，ISFET的电学特征可能改变，其检测可以提供关于在该位点存在病原体的信息。

    Resonance energy transfer based detection of nosocomial infection
    8.
    发明授权
    Resonance energy transfer based detection of nosocomial infection 有权
    共振能量转移检测医院感染

    公开(公告)号：US08180421B2

    公开(公告)日：2012-05-15

    申请号：US11954848

    申请日：2007-12-12

    申请人： Erica M. Phillips ,  Richard Hantke ,  Daniel Baird ,  Mike Rainone ,  Thomas Edward Plowman ,  Talbot Presley

    发明人： Erica M. Phillips ,  Richard Hantke ,  Daniel Baird ,  Mike Rainone ,  Thomas Edward Plowman ,  Talbot Presley

    IPC分类号： A61B5/1455 ,  G01N21/00

    CPC分类号： A61B5/0059 ,  A61B5/445 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/66 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/7703 ,  G01N2021/6441 ,  G01N2021/7716 ,  G01N2021/772 ,  G01N2021/773 ,  G01N2201/0221

    摘要： Disclosed herein are methods and devices for detection of hospital acquired infections. Disclosed methods may be utilized for continuous in vivo monitoring of a potential infection site or for periodic in vitro monitoring of tissue or fluid from a patient and may be utilized to alert patients and/or health care providers to the presence of a pathogen at an early stage of infection. Disclosed methods utilize fluorophore pairs that optically interact with one another according to Forster resonance energy transfer (FRET) or bioluminescence resonance energy transfer (BRET) mechanism. One member of the pair or a cofactor that interacts with an enzyme to form a member of the pair may be tethered to a device by a substrate that is specific for an enzyme expressed by a targeted pathogen. Upon interaction of the enzyme with the substrate, an optically detectable signal may be altered or initiated, detection of which may then provide information as to the existence of the pathogen at the site.

    摘要翻译： 本文公开了用于检测医院获得性感染的方法和装置。 公开的方法可以用于潜在感染部位的连续体内监测或用于周期性体外监测来自患者的组织或液体，并且可以用于早期警告患者和/或保健提供者病原体的存在 感染阶段 公开的方法利用根据福斯特共振能量转移（FRET）或生物发光共振能量转移（BRET）机制彼此光学相互作用的荧光团对。 该对中的一个成员或与酶相互作用以形成该对成员的辅因子可以通过对由靶向病原体表达的酶特异性的底物连接到装置上。 当酶与底物相互作用时，可以改变或开始光学可检测的信号，其检测可随后提供关于该位点病原体存在的信息。