公开(公告)号：US09060889B2

公开(公告)日：2015-06-23

申请号：US12693593

申请日：2010-01-26

申请人： Richard Bliss ,  Justin Goshgarian ,  Rui Lam ,  Padraig Savage ,  Erik Griswold ,  Gianfranco Pellegrini ,  Matthew Baldwin ,  Lance Ensign

发明人： Richard Bliss ,  Justin Goshgarian ,  Rui Lam ,  Padraig Savage ,  Erik Griswold ,  Gianfranco Pellegrini ,  Matthew Baldwin ,  Lance Ensign

IPC分类号： A61F2/06 ,  A61F2/88 ,  A61F2/915

CPC分类号： B21F45/008 ,  A61F2/88 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91525 ,  A61F2002/91558 ,  B21F1/04 ,  B21F3/02 ,  B23K31/027 ,  B23K2101/22 ,  B23K2201/22 ,  Y10T29/49826

摘要： A stent includes a continuous wave form having a plurality of struts and a plurality of crowns throughout the wave form. Each crown connects two adjacent struts. The wave form is wrapped around a longitudinal axis to define a central portion and two end portions located on opposite sides the central portion. The central portion includes a plurality of turns wrapped around the longitudinal axis and oriented at a first pitch angle relative to the longitudinal axis. The end portions each include a plurality of turns wrapped around the longitudinal axis and oriented at different pitch angles, and an end turn oriented at an angle relative to the longitudinal axis. The different pitch angles of the end portions are between the first pitch angle and the angle of the end turn relative to the longitudinal axis.

摘要翻译： 支架包括具有整个波浪形状的多个支柱和多个冠部的连续波形。 每个皇冠连接两个相邻的支柱。 波形围绕纵向轴线包围以限定位于中心部分的相对侧上的中心部分和两个端部部分。 中心部分包​​括围绕纵向轴线缠绕并相对于纵向轴线以第一俯仰角定向的多个匝。 端部分别包括围绕纵向轴线缠绕并以不同的俯仰角定向的多个匝和相对于纵向轴线成一定角度定向的端匝。 端部的不同桨距角位于第一桨距角和端匝相对于纵向轴线的角度之间。

公开(公告)号：US20130255347A1

公开(公告)日：2013-10-03

申请号：US13438732

申请日：2012-04-03

申请人： Lance Ensign ,  Erik Griswold

发明人： Lance Ensign ,  Erik Griswold

IPC分类号： B21D13/00 ,  B21F1/04

CPC分类号： B21F45/008 ,  A61F2/86 ,  A61F2/88 ,  A61F2/90 ,  A61F2/915 ,  A61F2240/001 ,  B21F1/04

摘要： A method for forming a wave form for a stent includes moving a first forming portion of a first forming member across an axis along which a formable material is provided in a first direction substantially perpendicular to the axis to engage and deform the formable material while engaging the formable material with a first forming portion of the second forming member. The method includes moving the first forming portion of the first forming member and the first forming portion of the second forming member across the axis in a second direction that is substantially opposite the first direction to draw and form the formable material over the first forming portion of the second forming member, disengaging the first forming member from the formable material, and rotating the first forming member to position a second forming portion of the first forming member to face the formable material.

摘要翻译： 用于形成用于支架的波形的方法包括使第一成形部件的第一成形部分沿着基本上垂直于轴线的第一方向穿过可成形材料的轴线移动，以使可成形材料接合和变形，同时接合 可成形材料，其具有第二成形构件的第一形成部分。 该方法包括使第一成形部件的第一成形部分和第二成形部件的第一成形部分沿着与第一方向基本相反的第二方向跨越轴线移动，以在第一成形部件的第一成形部分上方形成可成形材料 所述第二成形构件将所述第一成形构件与所述可成形材料分离，并且使所述第一成形构件旋转以将所述第一成形构件的第二成形部分定位成可成形材料。

公开(公告)号：US20120239002A1

公开(公告)日：2012-09-20

申请号：US13047525

申请日：2011-03-14

申请人： Erik Griswold

发明人： Erik Griswold

IPC分类号： A61M25/00

CPC分类号： A61M25/0074 ,  A61M2025/0079

摘要： A catheter system for delivery of a medical implant, the system including a cap removably covering an open distal end of a catheter. An elongate actuator wire is fixedly attached to the cap, extends through a lumen of the catheter, and has a distal region that can assume a pre-formed shape when unconstrained by the catheter lumen. The pre-formed shape of the wire distal region defines a bend adapted to laterally deflect the cap from the catheter distal end when assuming the pre-formed shape. At least a portion of the lumen adjacent the catheter distal end is sized and shaped to slidably receive the medical implant alongside the actuator wire. A push rod extends through the catheter lumen for ejecting the medical implant from the catheter distal end. Methods of using the invention are also disclosed.

摘要翻译： 一种用于输送医疗植入物的导管系统，该系统包括可移除地覆盖导管的开放远端的盖。 细长致动器线固定地附接到帽，延伸穿过导管的内腔，并且具有远端区域，当未被导管内腔受约束时，可以呈现预成形形状。 电线远端区域的预先形成的形状限定了弯曲部，其适于在假设预成形形状时使帽从导管远端侧向偏转。 与导管远端相邻的腔的至少一部分的尺寸和形状被设计成沿着致动器线可滑动地容纳医用植入物。 推杆延伸穿过导管内腔，用于从导管远端喷射医用植入物。 还公开了使用本发明的方法。

公开(公告)号：US20120101413A1

公开(公告)日：2012-04-26

申请号：US13278081

申请日：2011-10-20

申请人： Robert J. Beetel ,  Erik Griswold ,  Denise Zarins ,  Maria G. Aboytes

发明人： Robert J. Beetel ,  Erik Griswold ,  Denise Zarins ,  Maria G. Aboytes

IPC分类号： A61B18/04 ,  A61B18/08 ,  A61B18/14 ,  A61N7/02 ,  A61B18/18 ,  B23P17/04 ,  A61B18/20

CPC分类号： A61B18/1492 ,  A61B18/082 ,  A61B18/24 ,  A61B2018/00029 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00642 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/1861 ,  A61B2218/002 ,  A61N7/022 ,  A61N2007/003 ,  Y10T29/49826

摘要： Catheter apparatuses having expandable mesh structures and associated systems and methods for intravascular renal neuromodulation are disclosed herein. A catheter treatment device includes an expandable mesh structure configured to position an energy delivery element in contact with a renal artery via an intravascular path. The mesh structure can assume an expanded configuration for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function. A collapsed configuration may facilitate insertion and/or removal of the catheter or repositioning of the energy delivery element within the renal artery.

摘要翻译： 本文公开了具有可扩张网状结构的导管装置和用于血管内肾神经调节的相关系统和方法。 导管治疗装置包括可扩张网状结构，其构造成通过血管内路径将能量递送元件定位成与肾动脉接触。 网状结构可以采取扩展配置，用于直接和/或间接施加热和/或电能以加热或以其他方式电调节有助于肾功能的神经纤维。 折叠构型可以促进导管的插入和/或移除或能量递送元件在肾动脉内的重新定位。

公开(公告)号：US20110264194A1

公开(公告)日：2011-10-27

申请号：US12768235

申请日：2010-04-27

申请人： Erik Griswold

发明人： Erik Griswold

IPC分类号： A61F2/82 ,  A61B5/00

CPC分类号： A61B5/02152 ,  A61B5/0031 ,  A61B5/6862 ,  A61F2/82 ,  A61F2/962 ,  A61F2250/0002

摘要： An implant centering system includes a sensor connected to a hollow cylindrical anchor via at least two struts. The hollow cylindrical anchor is transformable between a radially compressed configuration for delivery and a radially expanded configuration for lodging against a vessel wall. The struts longitudinally relocate the sensor between a first position in which the sensor is longitudinally spaced apart from the radially compressed anchor, and a second position in which the sensor is at least partially within a lumen of the radially expanded anchor and radially centered within vessel. In one embodiment, the struts are heat-set into a curved configuration and an externally applied force longitudinally relocates the sensor until the struts lock over center into their heat-set configuration. In another embodiment, radial expansion of the anchor longitudinally relocates the sensor without an externally applied force.

摘要翻译： 植入物定心系统包括经由至少两个支柱连接到中空圆柱形锚固件的传感器。 中空圆柱形锚固件可在用于输送的径向压缩构造和用于抵靠血管壁的径向扩张构型之间变形。 支柱纵向地将传感器重新定位在传感器与径向压缩的锚固件纵向间隔开的第一位置和第二位置，在第二位置，传感器至少部分地位于径向膨胀的锚固体的内腔中并且在容器内径向居中。 在一个实施例中，支柱被热定形成弯曲构型，并且外部施加的力纵向地重新定位传感器，直到支柱锁定在其中心为其热定形构造。 在另一个实施例中，锚的径向膨胀纵向地重新定位传感器而没有外部施加的力。

公开(公告)号：US20110251660A1

公开(公告)日：2011-10-13

申请号：US12759173

申请日：2010-04-13

申请人： Erik Griswold

发明人： Erik Griswold

IPC分类号： A61N1/05

CPC分类号： A61N1/3756 ,  A61B17/3468 ,  A61N1/057 ,  A61N1/37205 ,  A61N1/37518

摘要： A fixation device for retaining a leadless medical implant to tissue includes an annular collar and an array of self-expanding tines extending from the collar. When deployed, the annular collar encircles the implant and the tines are preset to splay outwardly from the implant to grab body tissue and anchor the implant at a treatment site. The implant and fixation device are contained within a sheath for delivery to the treatment site and a pushing force is applied to a pusher of the delivery system to distally advance the fixation device relative to the implant and deploy the tines. A distal end of the implant having an electrode may form a distal tip of the delivery system, and a potential implantation site may be tested prior to deployment of the fixation device to allow for easy repositioning of the implant if the potential implantation site is determined to be unacceptable.

摘要翻译： 用于将无引线医用植入物保持在组织上的固定装置包括环形环和从套环延伸的自膨胀齿的阵列。 当部署时，环形套环环绕植入物，并且预定齿从植入物向外张开以抓住身体组织并将植入物锚固在治疗部位。 植入物和固定装置包含在护套内用于输送到治疗部位，并且将推力施加到输送系统的推动器以相对于植入物远端地推进固定装置并且部署尖齿。 具有电极的植入物的远端可以形成递送系统的远端，并且可以在部署固定装置之前测试潜在的植入部位，以便如果将潜在的植入部位确定为 不可接受

公开(公告)号：US20110067471A1

公开(公告)日：2011-03-24

申请号：US12693574

申请日：2010-01-26

申请人： Erik Griswold

发明人： Erik Griswold

IPC分类号： B21F3/02 ,  B21F45/00 ,  B21F1/04

CPC分类号： B21F45/008 ,  A61F2/88 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91525 ,  A61F2002/91558 ,  B21F1/04 ,  B21F3/02 ,  B23K31/027 ,  B23K2101/22 ,  Y10T29/49826

摘要： A method for forming a wave form for a stent includes providing a length of a formable material from a supply of the formable material in a feeder along an axis in a first direction in between a first forming member and a second forming member. The second forming member is positioned closer to the feeder than the first forming member. The length is about the length of a substantially straight portion of the wave form. The method also includes moving the first forming member in a second direction substantially perpendicular to the first direction to a position in contact with the formable material, and moving the second forming member in a third direction substantially opposite the second direction to wrap the formable material about a distal end of the first forming member.

摘要翻译： 用于形成用于支架的波形的方法包括：在第一形成构件和第二形成构件之间沿着第一方向上的轴线从供体中的可成形材料的供给提供一定长度的可成形材料。 第二成形构件定位成比第一成形构件更靠近进料器。 该长度大约是波形的基本上直的部分的长度。 该方法还包括将第一形成构件沿基本上垂直于第一方向的第二方向移动到与可成形材料接触的位置，并且在与第二方向大致相反的第三方向上移动第二成形构件以将可成形材料包裹在约 第一成形构件的远端。

公开(公告)号：US08831741B2

公开(公告)日：2014-09-09

申请号：US13047525

申请日：2011-03-14

申请人： Erik Griswold

发明人： Erik Griswold

IPC分类号： A61N1/05 ,  A61M39/24 ,  A61M25/00

CPC分类号： A61M25/0074 ,  A61M2025/0079

摘要： A catheter system for delivery of a medical implant, the system including a cap removably covering an open distal end of a catheter. An elongate actuator wire is fixedly attached to the cap, extends through a lumen of the catheter, and has a distal region that can assume a pre-formed shape when unconstrained by the catheter lumen. The pre-formed shape of the wire distal region defines a bend adapted to laterally deflect the cap from the catheter distal end when assuming the pre-formed shape. At least a portion of the lumen adjacent the catheter distal end is sized and shaped to slidably receive the medical implant alongside the actuator wire. A push rod extends through the catheter lumen for ejecting the medical implant from the catheter distal end. Methods of using the invention are also disclosed.

摘要翻译： 一种用于输送医疗植入物的导管系统，该系统包括可移除地覆盖导管的开放远端的盖。 细长致动器线固定地附接到帽，延伸穿过导管的内腔，并且具有远端区域，当未被导管内腔受约束时，可以呈现预成形形状。 电线远端区域的预先形成的形状限定了弯曲部，其适于在假设预成形形状时使帽从导管远端侧向偏转。 与导管远端相邻的腔的至少一部分的尺寸和形状被设计成沿着致动器线可滑动地容纳医用植入物。 推杆延伸穿过导管内腔，用于从导管远端喷射医用植入物。 还公开了使用本发明的方法。

公开(公告)号：US08727996B2

公开(公告)日：2014-05-20

申请号：US13090834

申请日：2011-04-20

申请人： James Calvin Allan ,  Don Tran ,  Erik Griswold ,  Rudy Beasley ,  Arvind Srinivas

发明人： James Calvin Allan ,  Don Tran ,  Erik Griswold ,  Rudy Beasley ,  Arvind Srinivas

IPC分类号： A61B5/02 ,  A61B18/18 ,  A61M29/00 ,  A61F2/06 ,  A61N1/00

CPC分类号： A61B5/0215 ,  A61B5/6839 ,  A61B5/686

摘要： A delivery device for implanting a medical device that includes an expandable fixation member adapted to fix the position of the medical device within a lumen of a human body. The delivery device has an inner shaft rotatably disposed in a tubular outer shaft. A retention member is secured to and rotatable with the inner shaft and has a free end and a retainer portion adapted to protrude outwardly through an exit aperture in the outer shaft to extend circumferentially about the exterior of the outer shaft. The fixation member of the medical device may be retained on the tubular shaft in a low profile configuration by the outwardly protruding retainer portion and may be released to expand upon retraction of the retainer portion in response to rotation of the inner shaft.

摘要翻译： 一种用于植入医疗装置的输送装置，其包括适于将医疗装置的位置固定在人体内腔内的可扩张固定构件。 输送装置具有可旋转地设置在管状外轴中的内轴。 保持构件固定到内轴上并与内轴可旋转，并且具有自由端和适于从外轴的出口孔向外突出的保持器部分，以围绕外轴的外部周向延伸。 医疗装置的固定构件可以通过向外突出的保持器部分以低轮廓构造保持在管状轴上，并且可以在响应于内轴的旋转而缩回保持器部分时释放膨胀。

公开(公告)号：US08532790B2

公开(公告)日：2013-09-10

申请号：US12759173

申请日：2010-04-13

申请人： Erik Griswold

发明人： Erik Griswold

IPC分类号： A61N1/00

CPC分类号： A61N1/3756 ,  A61B17/3468 ,  A61N1/057 ,  A61N1/37205 ,  A61N1/37518

摘要： A fixation device for retaining a leadless medical implant to tissue includes an annular collar and an array of self-expanding tines extending from the collar. When deployed, the annular collar encircles the implant and the tines are preset to splay outwardly from the implant to grab body tissue and anchor the implant at a treatment site. The implant and fixation device are contained within a sheath for delivery to the treatment site and a pushing force is applied to a pusher of the delivery system to distally advance the fixation device relative to the implant and deploy the tines. A distal end of the implant having an electrode may form a distal tip of the delivery system, and a potential implantation site may be tested prior to deployment of the fixation device to allow for easy repositioning of the implant if the potential implantation site is determined to be unacceptable.

摘要翻译： 用于将无引线医用植入物保持在组织上的固定装置包括环形环和从套环延伸的自膨胀齿的阵列。 当部署时，环形套环环绕植入物，并且预定齿从植入物向外张开以抓住身体组织并将植入物锚固在治疗部位。 植入物和固定装置包含在护套内用于输送到治疗部位，并且将推力施加到输送系统的推动器以相对于植入物远端地推进固定装置并且部署尖齿。 具有电极的植入物的远端可以形成递送系统的远端，并且可以在部署固定装置之前测试潜在的植入部位，以便如果将潜在的植入部位确定为 不可接受