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15 条记录 (耗时 0.051 秒)

    Novel urea derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and novel use
    7.
    发明申请
    Novel urea derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and novel use 失效
    新型尿素衍生物，其制备方法，作为药物的用途，药物组合物和新用途

    公开(公告)号：US20070173502A1

    公开(公告)日：2007-07-26

    申请号：US11644343

    申请日：2006-12-22

    申请人： Pierre Deprez ,  Marcel Patek

    发明人： Pierre Deprez ,  Marcel Patek

    IPC分类号： A61K31/5375 ,  A61K31/4965 ,  A61K31/495

    CPC分类号： C07D295/13 ,  C07C275/24 ,  C07C275/34 ,  C07D407/12 ,  Y02P20/55

    摘要： The invention relates to new products of formula (I): in which: Y represents oxygen or sulphur, Z represents C═CH2, CH—CH3 or CH2, R1 represents hydrogen, morpholinyl or the  radical. In which the two nitrogen atoms are linear or form a cyclic radical, X represents carbonyl, alkylene or alkenylene, linear or branched, containing at most 6 carbon atoms optionally interrupted by oxygen or sulphur, R4, R5 and R6 represent hydrogen, a protective group of the nitrogen, alkyl, cycloalkyl, aryl and arylalkyl optionally substituted, R2 represents alkyl optionally substituted by aryl, heteroaryl or —NR4R5, R3 represents alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl optionally substituted, these products being in all isomer forms and the salts, as medicaments.

    摘要翻译： 本发明涉及式（I）的新产物：其中：Y表示氧或硫，Z表示C-CH 2，CH-CH 3或CH 2，R 1表示氢，吗啉基或基团。 其中两个氮原子是直链或形成环状基团，X表示直链或支链的羰基，亚烷基或亚烯基，其含有至多6个碳原子，任选地被氧或硫中断，R4，R5和R6代表氢，保护基 任选取代的氮，烷基，环烷基，芳基和芳基烷基，R 2表示任选被芳基，杂芳基或-NR 4 R 5取代的烷基，R 3表示任选取代的烷基，环烷基，芳基，杂芳基，芳基烷基或杂芳基烷基， 和盐，作为药物。