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    Iron Oxide Nanocapsule, Method of Manufacturing the Same, and MRI Contrast Agent Using the Same
    2.
    发明申请
    Iron Oxide Nanocapsule, Method of Manufacturing the Same, and MRI Contrast Agent Using the Same 有权
    氧化铁纳米胶囊，其制造方法和使用其的MRI造影剂

    公开(公告)号：US20140328768A1

    公开(公告)日：2014-11-06

    申请号：US13818734

    申请日：2011-08-31

    申请人： Eun Byul Kwon ,  Bong Sik Jeon ,  Eung Gyu Kim ,  Ju Young Park ,  Wan Jae Myeong

    发明人： Eun Byul Kwon ,  Bong Sik Jeon ,  Eung Gyu Kim ,  Ju Young Park ,  Wan Jae Myeong

    IPC分类号： A61K49/18 ,  B01J13/06

    CPC分类号： A61K49/1863 ,  A61K49/12 ,  A61K49/126 ,  A61K49/128 ,  A61K49/1818 ,  A61K49/1827 ,  A61K49/1851 ,  B01J13/06 ,  B82Y5/00

    摘要： Provided is an iron oxide nanocapsule which has extremely excellent water dispersibility, which is very stable in the body and which has very excellent MRI contrast ability, a method of manufacturing the same, and an MRI contrast agent using the same. The method of manufacturing the iron oxide nanocapsule includes the steps of: thermally decomposing an iron complex to prepare hydrophobic ligand-bonded iron oxide nanoparticles; and encapsulating the hydrophobic ligand-bonded iron oxide nanoparticles by a carboxymethyldextrandodecylamine conjugate encapsulation material or a dextran-linoleic acid conjugate encapsulation material to form an iron oxide nanocapsule.

    摘要翻译： 本发明提供一种氧化铁纳米胶囊，其具有非常优异的水分散性，其在体内非常稳定，具有非常优异的MRI对比能力，其制造方法和使用其的MRI造影剂。 制造氧化铁纳米胶囊的方法包括以下步骤：热分解铁络合物以制备疏水配体键合的氧化铁纳米颗粒; 并用羧甲基十四烷基胺偶联剂包封材料或葡聚糖 - 亚油酸共轭物包封材料封装疏水配体键合的氧化铁纳米颗粒，以形成氧化铁纳米胶囊。

    MRI contrast agent for lymphography based on iron oxide nanoparticles and method for imaging lymph node using the same
    5.
    发明授权
    MRI contrast agent for lymphography based on iron oxide nanoparticles and method for imaging lymph node using the same 有权
    用于基于氧化铁纳米颗粒的淋巴造影剂的MRI造影剂和使用其的淋巴结成像方法

    公开(公告)号：US08906346B2

    公开(公告)日：2014-12-09

    申请号：US14000301

    申请日：2012-06-20

    申请人： Ju Young Park ,  Wan Jae Myeong ,  Bong-Sik Jeon ,  Eung Gyu Kim ,  Eun Byul Kwon ,  Taeghwan Hyeon ,  Daishun Ling

    发明人： Ju Young Park ,  Wan Jae Myeong ,  Bong-Sik Jeon ,  Eung Gyu Kim ,  Eun Byul Kwon ,  Taeghwan Hyeon ,  Daishun Ling

    IPC分类号： A61K49/04 ,  A61K49/12 ,  A61K49/18 ,  B82Y15/00

    CPC分类号： A61K49/124 ,  A61K49/1857 ,  A61K49/186 ,  B82Y15/00

    摘要： Provided are a contrast agent for contrast imaging lymph node, which includes iron oxide nanoparticles dispersed and stabilized in an aqueous medium by a mussel adhesive protein-mimetic copolymer, a method for contrast enhanced lymphography using the foregoing contrast agent, and a method for diagnosis of lymph node cancers using the foregoing contrast agent. Using such a mussel adhesive protein-mimetic copolymer, the surface of iron oxide is modified and dispersed well in water to prepare a colloidal solution, which in turn forms the contrast agent containing the colloidal solution. The inventive contrast agent does not have toxicity and is easily taken up to the lymph node to exhibit excellent contrast imaging effects. The contrast agent of the present invention is useful for diagnosis of metastatic cancers.

    摘要翻译： 本发明提供对比成像淋巴结的造影剂，其包括通过贻贝粘合蛋白模拟共聚物在水性介质中分散和稳定的氧化铁纳米颗粒，使用前述造影剂的对比度增强淋巴造影术的方法和诊断方法 使用上述造影剂的淋巴结癌。 使用这种贻贝粘合蛋白模拟共聚物，将氧化铁的表面改性并充分分散在水中以制备胶体溶液，这又形成含有胶体溶液的造影剂。 本发明的造影剂不具有毒性，并且容易吸收到淋巴结以显示出优异的对比度成像效果。 本发明的造影剂可用于诊断转移性癌症。

    Hydrophilic nanoparticles surface-modified with monosaccharide phosphate or monosaccharide phosphate derivatives, its colloidal solution and use thereof
    7.
    发明授权
    Hydrophilic nanoparticles surface-modified with monosaccharide phosphate or monosaccharide phosphate derivatives, its colloidal solution and use thereof 有权
    用单糖磷酸酯或单糖磷酸酯衍生物表面改性的亲水性纳米颗粒，其胶体溶液及其用途

    公开(公告)号：US09457104B2

    公开(公告)日：2016-10-04

    申请号：US14236502

    申请日：2012-08-03

    申请人： Eung Gyu Kim ,  Bong-Sik Jeon ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

    发明人： Eung Gyu Kim ,  Bong-Sik Jeon ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

    IPC分类号： A61B5/055 ,  A61K9/16 ,  A61K49/18 ,  A61K47/26 ,  A61K9/51 ,  A61K9/50

    CPC分类号： A61K49/1824 ,  A61B5/055 ,  A61K9/5036 ,  A61K9/5115 ,  A61K47/26 ,  A61K49/1845

    摘要： Disclosed are a composition including hydrophilic nanoparticles that have a monosaccharide-phosphate or a derivative thereof adhered to the surface thereof, a colloidal solution of the composition dispersed in water, and a magnetic resonance imaging contrast agent including the colloidal solution. According to the present invention, nanoparticles having biocompatibility and excellent water-dispersibility can be prepared by modifying the surface of inorganic nanoparticles. The prepared nanoparticles may be effectively used in a variety of applications including, for example, in vivo imaging applications such as an MRI contrast agent, nano-electronic convergence technologies such as a quantum dot light emitting device, biomedical applications such as hyperthermia, or the like. Moreover, compared to existing nanoparticles dispersed by a dispersion stabilizer known in the art, excellent dispersion stability and a relatively small hydrodynamic diameter may be attained.

    摘要翻译： 公开了包含粘附在其表面上的单糖 - 磷酸酯或其衍生物的亲水性纳米颗粒，分散在水中的组合物的胶体溶液和包含胶体溶液的磁共振成像造影剂的组合物。 根据本发明，通过改变无机纳米粒子的表面，可以制备具有生物相容性和优异的水分散性的纳米粒子。 所制备的纳米颗粒可以有效地用于各种应用，包括例如体内成像应用如MRI造影剂，纳米电子收敛技术如量子点发光器件，生物医学应用如热疗，或 喜欢。 此外，与通过本领域已知的分散稳定剂分散的现有纳米颗粒相比，可以获得优异的分散稳定性和相对较小的流体动力学直径。

    MRI CONTRAST AGENT FOR LYMPHOGRAPHY BASED ON IRON OXIDE NANOPARTICLES AND METHOD FOR IMAGING LYMPH NODE USING THE SAME
    8.
    发明申请
    MRI CONTRAST AGENT FOR LYMPHOGRAPHY BASED ON IRON OXIDE NANOPARTICLES AND METHOD FOR IMAGING LYMPH NODE USING THE SAME 有权
    基于氧化铁纳米颗粒的MRI对比剂和用于成像使用其的淋巴结的方法

    公开(公告)号：US20140023594A1

    公开(公告)日：2014-01-23

    申请号：US14000301

    申请日：2012-06-20

    申请人： Ju Young Park ,  Wan Jae Myeong ,  Bong-Sik Jeon ,  Eung Gyu Kim ,  Eun Byul Kwon ,  Taeghwan Hyeon ,  Daishun Ling

    发明人： Ju Young Park ,  Wan Jae Myeong ,  Bong-Sik Jeon ,  Eung Gyu Kim ,  Eun Byul Kwon ,  Taeghwan Hyeon ,  Daishun Ling

    IPC分类号： A61K49/12

    CPC分类号： A61K49/124 ,  A61K49/1857 ,  A61K49/186 ,  B82Y15/00

    摘要： Provided are a contrast agent for contrast imaging lymph node, which includes iron oxide nanoparticles dispersed and stabilized in an aqueous medium by a mussel adhesive protein-mimetic copolymer, a method for contrast enhanced lymphography using the foregoing contrast agent, and a method for diagnosis of lymph node cancers using the foregoing contrast agent. Using such a mussel adhesive protein-mimetic copolymer, the surface of iron oxide is modified and dispersed well in water to prepare a colloidal solution, which in turn forms the contrast agent containing the colloidal solution. The inventive contrast agent does not have toxicity and is easily taken up to the lymph node to exhibit excellent contrast imaging effects. The contrast agent of the present invention is useful for diagnosis of metastatic cancers.

    摘要翻译： 本发明提供对比成像淋巴结的造影剂，其包括通过贻贝粘合蛋白模拟共聚物在水性介质中分散和稳定的氧化铁纳米粒子，使用前述造影剂的对比度增强淋巴造影的方法，以及诊断方法 使用上述造影剂的淋巴结癌。 使用这种贻贝粘合蛋白模拟共聚物，将氧化铁的表面改性并充分分散在水中以制备胶体溶液，这又形成含有胶体溶液的造影剂。 本发明的造影剂不具有毒性，并且容易吸收到淋巴结以显示出优异的对比度成像效果。 本发明的造影剂可用于诊断转移性癌症。

    IRON OXIDE NANOCAPSULES, METHOD OF MANUFACTURING THE SAME, AND MRI CONTRAST AGENT USING THE SAME
    9.
    发明申请
    IRON OXIDE NANOCAPSULES, METHOD OF MANUFACTURING THE SAME, AND MRI CONTRAST AGENT USING THE SAME 有权
    氧化铁纳米粒子，其制造方法和使用其的MRI对比剂

    公开(公告)号：US20130164223A1

    公开(公告)日：2013-06-27

    申请号：US13819525

    申请日：2011-08-30

    申请人： Bong-Sik Jeon ,  Eung Gyu Kim ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

    发明人： Bong-Sik Jeon ,  Eung Gyu Kim ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

    IPC分类号： A61K49/18

    CPC分类号： A61K49/1893 ,  A61K49/1824 ,  A61K49/1827 ,  A61K49/1839 ,  A61K49/1857 ,  A61K49/1887

    摘要： Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanoparticles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. 5≦100*Dμ(IO)/C ω(IO)  [Relation 1] 2.5≦100*Dμ(Cap)/C ω(Cap)  [Relation 2] 0.5 wt %≦F(IO)≦50 wt %  [Relation 3] 1 nm≦Dμ(IO)≦25 nm  [Relation 4] 50 nm≦Dμ(Cap)≦200 nm  [Relation 5]

    摘要翻译： 本发明提供一种具有高对比度的MRI造影剂的氧化铁纳米胶囊，其中附着有疏水性配体的多种氧化铁纳米粒子被包封在包含可生物降解的聚合物和表面活性剂的包封材料中，并且满足关系1,2， 3，4和5。 还提供了一种制造氧化铁纳米胶囊的方法。 5 @ 100 * Dmu（IO）/Cω（IO）[关系1] 2.5×100×Dmu（Cap）/Cω（Cap）[关系2] 0.5wt％@ F（IO）@ 50wt％ 3] 1nm @ Dmu（IO）@ 25nm [关系4] 50nm @ Dmu（Cap）@ 200nm [关系5]