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    Compounds for enzyme inhibition
    4.
    发明申请
    Compounds for enzyme inhibition 审中-公开
    用于酶抑制的化合物

    公开(公告)号：US20060088471A1

    公开(公告)日：2006-04-27

    申请号：US11254541

    申请日：2005-10-19

    申请人： Mark Bennett ,  Tonia Buchholz ,  Susan Demo ,  Guy Laidig ,  Evan Lewis ,  Mark Smyth

    发明人： Mark Bennett ,  Tonia Buchholz ,  Susan Demo ,  Guy Laidig ,  Evan Lewis ,  Mark Smyth

    IPC分类号： A61K51/00 ,  C07K16/46 ,  C07K5/04 ,  C07K5/06

    CPC分类号： C07K5/0812 ,  C07K1/13 ,  C07K5/06165 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/1016 ,  C12Q1/34 ,  C12Q1/37 ,  G01N33/573 ,  G01N2333/976 ,  G01N2500/00

    摘要： Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus, such as a detectable label. Along with therapeutic utilities, these peptide based compounds can be used in assays useful for screening, monitoring, diagnostic and/or dosing purposes.

    摘要翻译： 包括含杂原子的三元环的基于肽的化合物有效地选择性地抑制N末端亲核试剂（Ntn）水解酶的比活性。 具有多种活性的那些Ntn的活性可被所描述的化合物差别地抑制。 例如，本发明化合物可以选择性地抑制20S蛋白酶体的胰凝乳蛋白酶样和PGPH活性。 基于肽的化合物包括至少三种肽单元，环氧化物或氮丙啶，并且在N末端官能化，例如可检测标记。 与治疗用途一起，这些基于肽的化合物可用于用于筛选，监测，诊断和/或给药目的的测定中。

    Exit window milling assembly with improved restraining force
    5.
    发明申请
    Exit window milling assembly with improved restraining force 有权
    出口窗铣削组件具有改进的约束力

    公开(公告)号：US20070261840A1

    公开(公告)日：2007-11-15

    申请号：US11434358

    申请日：2006-05-15

    申请人： Calvin Stowe ,  Evan Lewis ,  Mohan Soni ,  Daniel Hart

    发明人： Calvin Stowe ,  Evan Lewis ,  Mohan Soni ,  Daniel Hart

    IPC分类号： E21B23/03

    CPC分类号： E21B29/06

    摘要： An assembly for milling a window in a tubular features a layout that keeps a restorative force normal to the whipstock slope acting on the window mill to help it track the whipstock ramp long enough for making an exit at the desired location. A string mill assembly is made long enough to allow such a restorative force to be created on the window mill as it advances down the ramp. The bearing or cutting structures on the string mill are positioned with respect to the window mill so that either the top of the string mill or at least the first bearing structure above the window mill presents at the top of the window as the window mill arrives at the position where it is desired that it make an exit. The lower bearing structure of the string mill also preferably has a rounded profile to facilitate its entrance on to the whipstock ramp without getting in a bind on the tubular wall adjacent the top of the window.

    摘要翻译： 用于铣削管道中的窗口的组件具有一种布局，其将恢复力保持垂直于作用在窗玻璃上的造斜斜坡，以帮助其跟踪造斜斜坡，足以使其在所需位置处出口。 弦碾机组件被制成足够长的时间，以允许在窗碾机上沿着斜坡进入时产生这样的修复力。 串磨机上的轴承或切割结构相对于窗口磨机定位，使得当研磨机到达时，弦磨机的顶部或窗玻璃上方的至少第一轴承结构呈现在窗口的顶部 希望它退出的位置。 串磨机的下轴承结构也优选具有圆形轮廓，以便于其进入造斜坡坡道而不会在邻近窗口顶部的管状壁上结合。