公开(公告)号：US20060223176A1

公开(公告)日：2006-10-05

申请号：US11097022

申请日：2005-03-31

申请人： Evgenia Mandrusov ,  Albert Chin ,  William Webler ,  Yan Shen ,  Robert Ainsworth ,  Eugene Michel

发明人： Evgenia Mandrusov ,  Albert Chin ,  William Webler ,  Yan Shen ,  Robert Ainsworth ,  Eugene Michel

IPC分类号： C12N5/00

CPC分类号： A61B17/3472 ,  A61B1/015 ,  A61B1/313 ,  A61B2017/00969 ,  A61B2217/005 ,  A61K35/28 ,  A61K2035/124 ,  A61M5/00 ,  A61M2202/10 ,  A61M2210/02 ,  A61M2210/125

摘要： Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.

摘要翻译： 描述了用于治疗心脏组织的系统和方法的许多实施例。 在一个实施方案中，从患者中提取骨髓细胞。 然后处理细胞以分离单核细胞，其然后可以在患者的心脏组织附近被递送回来。

公开(公告)号：US20060265043A1

公开(公告)日：2006-11-23

申请号：US11388355

申请日：2006-03-24

申请人： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

发明人： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61B5/02007 ,  A61B2017/22077 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/077 ,  A61F2220/0058 ,  A61F2250/0067 ,  A61M1/3613 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1056 ,  A61M2025/107 ,  A61M2025/1086 ,  A61M2025/1095

摘要： Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.

摘要翻译： 描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。 在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。 另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。

公开(公告)号：US20080103523A1

公开(公告)日：2008-05-01

申请号：US11923332

申请日：2007-10-24

申请人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

发明人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

IPC分类号： A61M29/00

CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

公开(公告)号：US20080041516A1

公开(公告)日：2008-02-21

申请号：US11923258

申请日：2007-10-24

申请人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

发明人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

IPC分类号： B29C53/60

CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

摘要翻译： 实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。 导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。 输送导管可以具有附件腔，同轴或共线腔，支撑心轴或其远端处的闭塞装置。 此外，根据一些实施例，闭塞装置可以是具有内衬和不同材料外层的单一材料或复合球囊，高顺应性低压气球或限制颗粒通过但不限制的过滤装置 限制流体，如血液。 可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

公开(公告)号：US20050015048A1

公开(公告)日：2005-01-20

申请号：US10800323

申请日：2004-03-11

申请人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

发明人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

IPC分类号： A61F2/958 ,  A61M29/00

CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial and/or co-linear lumen, a supporting mandrel, and/or an occlusion device at its distal end. Moreover, according to embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, and/or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

摘要翻译： 实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。 导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。 输送导管可以在其远端具有附属腔，同轴和/或共线的腔，支撑心轴和/或闭塞装置。 此外，根据实施例，闭塞装置可以是具有不同材料的内衬和外层的单一材料或复合球囊，高顺应性低压气球和/或限制颗粒通过而过滤装置 不限制流体，如血液。 可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

公开(公告)号：US20080103478A1

公开(公告)日：2008-05-01

申请号：US11923068

申请日：2007-10-24

申请人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

发明人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

IPC分类号： A61M31/00 ,  A61M25/10

CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

公开(公告)号：US08308683B2

公开(公告)日：2012-11-13

申请号：US12768431

申请日：2010-04-27

申请人： Michael J. Leonard ,  Binh T. Nguyen ,  William Webler

发明人： Michael J. Leonard ,  Binh T. Nguyen ,  William Webler

IPC分类号： A61M31/00

CPC分类号： A61M25/1002 ,  A61M25/0668 ,  A61M25/104 ,  A61M2025/0004 ,  A61M2025/0024 ,  A61M2025/0037 ,  A61M2025/0039 ,  A61M2025/0096 ,  A61M2025/0681 ,  A61M2025/105

摘要： An agent delivery catheter configured to deliver an agent to an inner surface of a patient's body lumen wall by forming an array of cells defining agent containment chambers at multiple locations along the catheter's shaft, while minimizing ischemic conditions during the procedure.

摘要翻译： 一种药剂递送导管，配置成通过在导管的轴的多个位置处形成限定药剂容纳室的细胞阵列，同时使手术过程中的缺血状况最小化，将药剂递送到患者体腔壁的内表面。

公开(公告)号：US20050182387A1

公开(公告)日：2005-08-18

申请号：US10778270

申请日：2004-02-13

申请人： William Webler

发明人： William Webler

IPC分类号： A61M25/06 ,  A61M25/00

CPC分类号： A61M25/0668

摘要： A peel-away shaft for a guiding catheter includes a shaft wall defining an open lumen of the catheter shaft. A peel-away region is defined over at least a partial length of the catheter shaft. A braid substantially encompasses the open lumen. The braid includes a region of discontinuity extending along the peel-away region. The region of discontinuity of the braid reduces the tear resistance of the shaft wall along the peel-away region.

摘要翻译： 用于引导导管的剥离轴包括限定导管轴的开口腔的轴壁。 剥离区域限定在导管轴的至少一部分长度上。 编织物基本上包围开口腔。 编织物包括沿剥离区域延伸的不连续区域。 编织物的不连续区域降低了沿着剥离区域的轴壁的抗撕裂性。

公开(公告)号：US20050124977A1

公开(公告)日：2005-06-09

申请号：US11031608

申请日：2005-01-05

申请人： Fernando Gonzalez ,  William Webler

发明人： Fernando Gonzalez ,  William Webler

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B17/34 ,  A61M25/16

CPC分类号： A61B17/3478 ,  A61B2017/00247 ,  A61B2017/22077 ,  A61B2018/00392 ,  A61M2025/0086 ,  A61M2025/0089

摘要： A catheter device having an elongated tubular member with a proximal end and a distal end, and a needle disposed near the distal end. In one embodiment, the needle has a rigid, penetrating tip coupled to a flexible portion by an overlapping joint. The flexible portion enables the needle to bend to a penetrating angle relative to the distal end of the elongated tubular member and penetrate a body tissue without kinking.

公开(公告)号：US20050070844A1

公开(公告)日：2005-03-31

申请号：US10676616

申请日：2003-09-30

申请人： Mina Chow ,  Barbara Stamberg ,  William Webler ,  John Simpson ,  August Yambao ,  Gabriel Asongwe ,  Jessica Chiu ,  Lili Liu ,  Dagmar Beyerlein

发明人： Mina Chow ,  Barbara Stamberg ,  William Webler ,  John Simpson ,  August Yambao ,  Gabriel Asongwe ,  Jessica Chiu ,  Lili Liu ,  Dagmar Beyerlein

IPC分类号： A61M25/00 ,  A61M25/01 ,  A61M31/00

CPC分类号： A61M25/0136 ,  A61M25/0012 ,  A61M25/0013 ,  A61M25/0029 ,  A61M25/005 ,  A61M25/0051 ,  A61M25/0054 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/0152 ,  A61M2025/004 ,  A61M2025/0063 ,  A61M2025/0089 ,  A61M2025/009 ,  A61M2025/0096 ,  A61M2025/015

摘要： A deflectable catheter assembly is disclosed. The assembly comprises a catheter shaft having a catheter proximal section and a catheter distal section, and at least one lumen extending therethrough. The catheter distal section is more flexible than the catheter proximal section. A tendon is disposed within a first lumen of said catheter shaft. The first lumen is approximately centrally located within the catheter shaft at the catheter proximal section. The first lumen is located off-center of the catheter shaft at the catheter distal section. The tendon is able to deflect the catheter distal section when being pulled on. A catheter handle is coupled to the catheter shaft at the catheter proximal section, the catheter handle includes a control mechanism to control the tendon.

摘要翻译： 公开了一种可偏转导管组件。 组件包括具有导管近端部分和导管远端部分的导管轴和延伸穿过其中的至少一个内腔。 导管远端部分比导管近端部分更灵活。 腱设置在所述导管轴的第一内腔内。 导管近端部分处的第一管腔大致位于导管轴的中心。 第一管腔位于导管远端部处的导管轴的中心。 当被拉扯时，肌腱能够使导管远端部分偏转。 导管手柄在导管近端部分处联接到导管轴，导管手柄包括用于控制腱的控制机构。