公开(公告)号：US20150344920A1

公开(公告)日：2015-12-03

申请号：US14654291

申请日：2013-12-23

Applicant: Evolva SA

Inventor： Jorgen Hansen ,  Patricia Hoyle ,  Michael Naesby ,  Joseph M. Sheridan ,  Jonathan R. Heal

IPC: C12P17/06 ,  C12P19/44 ,  C12N15/10

CPC classification number: C12P17/06 ,  C12N9/1025 ,  C12N9/1048 ,  C12N15/1079 ,  C12N15/52 ,  C12P19/44 ,  C12Y203/00 ,  C12Y204/00

Abstract: The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.

Abstract translation: 本公开提供了使用筛选方法鉴定具有改进的稳定性，颜色或色调的花青素的方法，并且在例如包含一个或多个异源糖基转移酶核酸分子的宿主细胞中产生具有改善的稳定性，颜色或色调的花青素 或更多的异源酰基转移酶核酸分子。

公开(公告)号：US11008592B2

公开(公告)日：2021-05-18

申请号：US16243670

申请日：2019-01-09

Applicant: International Flavors & Fragrances Inc. ,  Evolva SA

Inventor： Joergen Hansen ,  Esben Halkjaer Hansen ,  Honey Polur ,  Joseph M. Sheridan ,  Jonathan R. Heal ,  William D. O. Hamilton

IPC: C12P7/24 ,  C12N9/10 ,  C12N15/82 ,  A23L33/105 ,  C12N9/88 ,  C12N9/04 ,  C12P19/46 ,  C07K14/395

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.

公开(公告)号：US10119154B2

公开(公告)日：2018-11-06

申请号：US14654291

申请日：2013-12-23

Applicant: Evolva SA

Inventor： Jorgen Hansen ,  Patricia Hoyle ,  Michael Naesby ,  Joseph M. Sheridan ,  Jonathan R. Heal

IPC: C12P17/06 ,  C12N15/52 ,  C12N15/10 ,  C12P19/44 ,  C12N9/10

Abstract: The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.