公开(公告)号：US20180346953A1

公开(公告)日：2018-12-06

申请号：US15974429

申请日：2018-05-08

Applicant: EVOLVA SA

Inventor： Yaoquan Liu ,  Jorgen Hansen ,  Jens Houghton-Larsen ,  Muthuswamy Panchapagesa Murali ,  Sathish Kumar ,  Nina Nicoline Rasmussen

IPC: C12P33/20 ,  C12N9/02 ,  C12P33/12 ,  C12P33/08 ,  C12P33/00 ,  C12P19/56 ,  C12P19/18 ,  C12N9/90 ,  C12N9/14 ,  C12N9/10 ,  C12N15/80

CPC classification number: C12P33/20 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/1048 ,  C12N9/14 ,  C12N9/90 ,  C12N15/80 ,  C12P19/18 ,  C12P19/56 ,  C12P33/00 ,  C12P33/08 ,  C12P33/12 ,  C12Y114/00 ,  C12Y114/13132 ,  C12Y303/00 ,  C12Y504/99033

Abstract: The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.

公开(公告)号：US09957540B2

公开(公告)日：2018-05-01

申请号：US14761629

申请日：2014-02-06

Applicant: Evolva SA

Inventor： Michael Dalgaard Mikkelsen ,  Jorgen Hansen ,  Ernesto Simon ,  Federico Brianza ,  Angelika Semmler ,  Kim Olsson ,  Simon Carlsen ,  Louis Düring ,  Alexei Ouspenski ,  Paula Hicks

IPC: C12P19/56 ,  A23L2/60 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12N15/81 ,  A23L27/30

CPC classification number: C12P19/56 ,  A23L2/60 ,  A23L27/36 ,  A23V2002/00 ,  C12N9/0071 ,  C12N9/1051 ,  C12N9/1081 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/81 ,  C12Y204/01 ,  C12Y204/99

Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided herein.

公开(公告)号：US20160186225A1

公开(公告)日：2016-06-30

申请号：US14761629

申请日：2014-02-06

Applicant: EVOLVA SA

Inventor： Michael Dalgaard Mikkelsen ,  Jorgen Hansen ,  Ernesto Simon ,  Frederico Brianza ,  Angelika Semmler ,  Kim Olsson ,  Simon Carlsen ,  Louis Düring ,  Alexei Ouspenski ,  Paula Hicks

IPC: C12P19/56 ,  A23L2/60 ,  C12N9/10

CPC classification number: C12P19/56 ,  A23L2/60 ,  A23L27/36 ,  A23V2002/00 ,  C12N9/0071 ,  C12N9/1051 ,  C12N9/1081 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/81 ,  C12Y204/01 ,  C12Y204/99

Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.

Abstract translation: 本发明提供了重组生产甜菊糖苷和含有甜菊糖苷的组合物的方法。

公开(公告)号：US20150322473A1

公开(公告)日：2015-11-12

申请号：US14442694

申请日：2013-12-04

Applicant: EVOLVA SA

Inventor： Yaoquan Liu ,  Jorgen Hansen ,  Jens Houghton-Larsen ,  Muthuswamy Panchapagesa Murali ,  Sathish Kumar ,  Nina Nicoline Rasmussen

IPC: C12P19/56 ,  C12N9/10 ,  C12N9/90

CPC classification number: C12P33/20 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/1048 ,  C12N9/14 ,  C12N9/90 ,  C12N15/80 ,  C12P19/18 ,  C12P19/56 ,  C12P33/00 ,  C12P33/08 ,  C12P33/12 ,  C12Y114/00 ,  C12Y114/13132 ,  C12Y303/00 ,  C12Y504/99033

Abstract: The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.

Abstract translation: 本发明涉及借助于酶的方法来生产芒果苷。 特别地，本发明提出了可用于罗汉果苷生产的各种生物合成途径，并提供了可用于罗汉果苷生产的酶。 此外，本发明提供可用于实施本发明方法的重组宿主。

公开(公告)号：US20230279459A1

公开(公告)日：2023-09-07

申请号：US18052477

申请日：2022-11-03

Applicant: EVOLVA SA

Inventor： Michael Dalgaard Mikkelsen ,  Jorgen Hansen ,  Ernesto Simon ,  Federico Brianza ,  Angelika Semmler ,  Kim Olsson ,  Simon Carlsen ,  Louis Düring ,  Alexei Ouspenski ,  Paula Hicks

IPC: C12P19/56 ,  C12N9/02 ,  C12N9/90 ,  A23L2/60 ,  C12N9/10 ,  C12N15/81 ,  A23L27/30

CPC classification number: C12P19/56 ,  C12N9/0071 ,  C12N9/90 ,  A23L2/60 ,  C12Y204/01 ,  C12N9/1051 ,  C12N9/1081 ,  C12N9/1085 ,  C12N15/81 ,  A23L27/36 ,  C12Y204/99 ,  A23V2002/00

Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.

公开(公告)号：US11530431B2

公开(公告)日：2022-12-20

申请号：US16799541

申请日：2020-02-24

Applicant: EVOLVA SA

Inventor： Michael Dalgaard Mikkelsen ,  Jorgen Hansen ,  Ernesto Simon ,  Federico Brianza ,  Angelika Semmler ,  Kim Olsson ,  Simon Carlsen ,  Louis Düring ,  Alexei Ouspenski ,  Paula Hicks

IPC: C12P19/56 ,  A23L27/30 ,  A23L2/60 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12N15/81

Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.

公开(公告)号：US20220228185A1

公开(公告)日：2022-07-21

申请号：US17471615

申请日：2021-09-10

Applicant: EVOLVA SA

Inventor： Jens Houghton-Larsen ,  Paula Hicks ,  Michael Naesby ,  Thomas Tange Ostergaard ,  Jorgen Hansen ,  Michael Mikkelsen Dalgaard ,  Esben Hansen Halkjaer ,  Ernesto Simon ,  Sabina De Andrade Periera Tavares

IPC: C12P19/56 ,  C12N9/88 ,  C12N9/06 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12N15/81 ,  C12N15/82 ,  C12P19/44 ,  C12N15/63

Abstract: Recombiant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorgansims, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：US20200308617A1

公开(公告)日：2020-10-01

申请号：US16799541

申请日：2020-02-24

Applicant: EVOLVA SA

Inventor： Michael Dalgaard Mikkelsen ,  Jorgen Hansen ,  Ernesto Simon ,  Federico Brianza ,  Angelika Semmler ,  Kim Olsson ,  Simon Carlsen ,  Louis Düring ,  Alexei Ouspenski ,  Paula Hicks

IPC: C12P19/56 ,  A23L27/30 ,  A23L2/60 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12N15/81

Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.

公开(公告)号：US10465222B2

公开(公告)日：2019-11-05

申请号：US15974429

申请日：2018-05-08

Applicant: EVOLVA SA

Inventor： Yaoquan Liu ,  Jorgen Hansen ,  Jens Houghton-Larsen ,  Muthuswamy Panchapagesa Murali ,  Sathish Kumar ,  Nina Nicoline Rasmussen

IPC: C12P33/20 ,  C12N9/10 ,  C12P19/18 ,  C12P19/56 ,  C12P33/08 ,  C12N9/02 ,  C12N9/14 ,  C12N9/90 ,  C12P33/00 ,  C12P33/12 ,  C12N15/80

Abstract: The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.

公开(公告)号：US10392644B2

公开(公告)日：2019-08-27

申请号：US15382354

申请日：2016-12-16

Applicant: EVOLVA SA

Inventor： Ganesh M. Kishore ,  Jorgen Hansen ,  Jens Houghton-Larsen ,  Esben Halkjaer Hansen ,  Michael Dalgaard Mikkelsen ,  Sabina Tavares ,  Charlotte Blom

IPC: C12N9/10 ,  C12N9/88 ,  A23L2/60 ,  C12P19/56 ,  C12P15/00 ,  C07H15/256 ,  C12N9/04 ,  C12N9/90 ,  C12N9/02 ,  A23L27/30

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.