公开(公告)号：US20140377364A1

公开(公告)日：2014-12-25

申请号：US14481650

申请日：2014-09-09

Applicant: FIRMENICH SA

Inventor： Christopher M. GREGSON ,  Matthew P. SILLICK

IPC: A61K47/10 ,  A23L1/221 ,  A23G3/36 ,  A61K31/685

CPC classification number: A61K47/10 ,  A23G3/36 ,  A23G4/06 ,  A23G4/20 ,  A23L27/10 ,  A23L27/70 ,  A23L27/72 ,  A23L29/37 ,  A23P10/20 ,  A23P10/30 ,  A23V2002/00 ,  A23V2200/224 ,  A23V2250/6418 ,  A61K9/1623 ,  A61K31/685 ,  A23V2250/6402

Abstract: A spray-chilled particulate delivery system that has a crystalline matrix structure and comprises a volatile hydrophobic active ingredient and a carrier material selected from the group consisting of erythritol and mannitol and mixtures thereof wherein, relative to the total weight of the carrier material, 75% or more of the carrier material is in crystalline form. The process for preparing the delivery system comprises the steps of (i) forming a melt of a carrier material selected from the group consisting of erythritol and mannitol and mixtures thereof (ii) incorporating a volatile hydrophobic active ingredient into the melt (iii) forming a melt-mixture comprising an emulsion, dispersion or suspension of the volatile hydrophobic active ingredient in the melt (iv) forming discrete particles of the melt mixture, and (v) cooling the discrete particles, so as to form the crystalline delivery system.

Abstract translation: 具有结晶基质结构并包含挥发性疏水性活性成分和选自赤藻糖醇和甘露醇及其混合物的载体材料的喷雾冷却颗粒递送系统，其中相对于载体材料的总重量为75％ 或更多的载体材料是结晶形式。 制备递送系统的方法包括以下步骤：（i）形成选自由赤藓糖醇和甘露糖醇组成的组的载体材料的熔体及其混合物（ii）将挥发性疏水性活性成分掺入到熔融物中，形成 熔融混合物，其包含在熔体（iv）中的挥发性疏水性活性成分的乳液，分散体或悬浮液，形成熔融混合物的离散颗粒，和（v）冷却离散颗粒，以形成结晶递送系统。

公开(公告)号：US20150342235A1

公开(公告)日：2015-12-03

申请号：US14654841

申请日：2013-12-16

Applicant: FIRMENICH SA

Inventor： Christopher M. GREGSON ,  Matthew P. SILLICK ,  Jérôme BARRA ,  Angela DI PIETRO

IPC: A23L1/236 ,  A23C9/156 ,  A23L2/60

CPC classification number: C13B50/002 ,  A21D2/181 ,  A23C9/1307 ,  A23C9/156 ,  A23G3/36 ,  A23G4/06 ,  A23L2/60 ,  A23L5/00 ,  A23L27/31 ,  A23L27/33 ,  A23L27/60 ,  A23L29/30 ,  A23P10/20 ,  A23P10/22 ,  A23V2002/00 ,  A23V2250/628 ,  A23V2300/31 ,  A23V2300/36 ,  C13B50/004

Abstract: Sweeteners made from the co-crystallization of 3-(4-amino-2,2-dioxide-1H-benzo[c][1,2,6]thiadiazin-5-yloxy)-2′,2′-dimethyl-N-propylpropanamide (Compound I) having the structure: or salt thereof, with sugar in various ratios. The sugar co-crystallized sweeteners are very soluble in water and have no dusting problems.

Abstract translation: 由3-（4-氨基-2,2-二氧代-1H-苯并[c] [1,2,6]噻二嗪-5-基氧基）-2'，2'-二甲基-N - 丙基丙酰胺（化合物I），其结构为：或其盐，具有各种比例的糖。 糖结晶的甜味剂非常易溶于水，并且没有粉尘问题。