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公开(公告)号：US20230332085A1
公开(公告)日：2023-10-19
申请号：US18337146
申请日：2023-06-19
Applicant: FUJIFILM CORPORATION
Inventor： Shinichi NAKAI , Yoichi NAGAI , Nobuyuki HARAGUCHI , Shigehisa SUGIYAMA
CPC classification number: C12M29/04 , B01D61/145 , B01D61/146 , B01D61/147 , B01D61/18 , B01D61/58 , C12M29/10 , C12M29/18 , C12M33/14 , C12M37/02 , C12M39/00 , C12M47/02 , C12N5/0081 , B01D2311/25 , B01D2311/2688 , B01D2315/08 , B01D2315/10 , B01D2317/025
Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 µm or smaller, and 0
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公开(公告)号：US20170282144A1
公开(公告)日：2017-10-05
申请号：US15625020
申请日：2017-06-16
Applicant: FUJIFILM Corporation
Inventor： Susumu SUGIYAMA , Naoki YAMADA , Shigehisa SUGIYAMA , Yohei OKUBO , Takashi SASAKI , Tetsu ISHIGURO
CPC classification number: B01J13/04 , A61K9/127 , A61K9/1271 , A61K9/1277 , B01D1/00 , B01D5/006 , B01F3/0807 , B01F5/10 , B01F7/0075 , B01F2003/0842 , B01F2215/0032
Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.
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Patent Agency Ranking
公开(公告)号：US20180133676A1
公开(公告)日：2018-05-17
申请号：US15868092
申请日：2018-01-11
Applicant: FUJIFILM Corporation
Inventor： Susumu SUGIYAMA , Naoki YAMADA , Shigehisa SUGIYAMA , Yohei OKUBO , Takashi SASAKI , Tetsu ISHIGURO
CPC classification number: B01J13/04 , A61K9/127 , A61K9/1271 , A61K9/1277 , B01D1/00 , B01D5/006 , B01F3/0807 , B01F5/10 , B01F7/0075 , B01F2003/0842 , B01F2215/0032
Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.
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公开(公告)号：US20170281543A1
公开(公告)日：2017-10-05
申请号：US15625391
申请日：2017-06-16
Applicant: FUJIFILM Corporation
Inventor： Susumu SUGIYAMA , Naoki YAMADA , Shigehisa SUGIYAMA , Yohei OKUBO
CPC classification number: A61K9/1277 , A61K9/127 , A61K9/1271 , A61K31/7068 , B01F3/08 , B01F3/0807 , B01F5/0206 , B01F5/10 , B01F2215/0032 , B01J13/04 , B01J13/08 , B82Y5/00 , B82Y40/00
Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.
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公开(公告)号：US20190322975A1
公开(公告)日：2019-10-24
申请号：US16460983
申请日：2019-07-02
Applicant: FUJIFILM CORPORATION
Inventor： Shinichi NAKAI , Yoichi NAGAI , Nobuyuki HARAGUCHI , Shigehisa SUGIYAMA
Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 μm or smaller, and 0
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公开(公告)号：US20180133156A1
公开(公告)日：2018-05-17
申请号：US15868160
申请日：2018-01-11
Applicant: FUJIFILM Corporation
Inventor： Susumu SUGIYAMA , Naoki YAMADA , Shigehisa SUGIYAMA , Yohei OKUBO
CPC classification number: A61K9/1277 , A61K9/127 , A61K9/1271 , A61K31/7068 , B01F3/08 , B01F3/0807 , B01F5/0206 , B01F5/10 , B01F2215/0032 , B01J13/04 , B01J13/08 , B82Y5/00 , B82Y40/00
Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.
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7.发明申请FIBER MANUFACTURING METHOD, NON-WOVEN FABRIC MANUFACTURING METHOD, AND FIBER MANUFACTURING EQUIPMENT 审中-公开纤维制造方法，非织造织物制造方法和纤维制造设备公开(公告)号：US20160354964A1
公开(公告)日：2016-12-08
申请号：US15231094
申请日：2016-08-08
Applicant: FUJIFILM Corporation
Inventor： Yukihiro KATAI , Shigehisa SUGIYAMA , Seiji KASAHARA , Yasuhisa SHIMODA , Masahiro ESAKI
CPC classification number: B29C47/0021 , B29B11/04 , B29C47/0014 , B29K2001/12 , B29L2007/008 , D01D5/06 , D01F2/28 , D01F13/02 , D04H1/4258 , D04H1/72 , D04H1/736 , D21H13/02 , Y02P70/627
Abstract: A fiber manufacturing method includes the following steps of: dissolving a polymer in a solvent to obtain a polymer solution; spraying the polymer solution into a liquid heated to a boiling point of the solvent or higher, and evaporating the solvent to precipitate a fibrous polymer in a sealed precipitation tank, the liquid being immiscible with the polymer and the solvent; conveying the precipitated fibrous polymer in a liquid from the precipitation tank; water-rinsing the fibrous polymer conveyed in the liquid in the conveying step in a sealed water-rinsing tank; conveying the water-rinsed fibrous polymer in a liquid from the water-rinsing tank; and cooling and condensing solvent gas that is generated in the spraying step and the water-rinsing step.
Abstract translation: 纤维制造方法包括以下步骤：将聚合物溶解在溶剂中以获得聚合物溶液; 将聚合物溶液喷射到加热到溶剂沸点以上的液体中，蒸发溶剂使纤维聚合物沉淀在密封的沉淀槽中，该液体与聚合物和溶剂不混溶; 将沉淀的纤维聚合物从沉淀槽输送到液体中; 在输送步骤中在密封的水冲洗槽中水洗在液体中输送的纤维聚合物; 从水洗槽输送水冲洗的纤维聚合物液体; 以及在喷雾步骤和水漂洗步骤中产生的冷却和冷凝溶剂气体。
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