专利检索 ap:("FUJIFILM Cellular Dynamics, Inc." OR "The United States of America, as represented by the Secretary, Department of Health AND Human Servic") AND inv:"Erich BERNDT" 第 1 页

1.

发明公开
BILAYER OF RETINAL PIGMENTED EPITHELIUM AND PHOTORECEPTORS AND USE THEREOF 审中-公开

公开(公告)号：US20230212509A1

公开(公告)日：2023-07-06

申请号：US18000008

申请日：2021-05-28

申请人： FUJIFILM Cellular Dynamics, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Andrew DIAS , Erich BERNDT , Lucas CHASE , Juan AMARAL , Arvydas MAMINISHKIS , Kapil BHARTI

IPC分类号： C12N5/0793 , C12N5/079 , A61L27/36 , C12N5/00 , A61L27/18 , A61L27/56 , A61L27/58 , A61L27/20 , A61L27/22 , A61L27/54

CPC分类号： C12N5/062 , A61L27/18 , A61L27/20 , A61L27/54 , A61L27/56 , A61L27/58 , A61L27/227 , A61L27/3641 , C12N5/0056 , C12N5/0621 , A61L2430/16 , C12N2533/40 , C12N2533/50 , C12N2533/90

摘要： Provided herein are methods of producing a distinct bilayer culture of retinal epithelial cells (RPE) with photoreceptor cells and/or photoreceptor precursor cells (PR/PRP). Further provided herein is a therapy comprising transplantation of the RPE and PR/PRP bilayer as well as methods for testing candidate drugs using the bilayer.

2.

发明公开
RETINAL PIGMENTED EPITHELIUM AND PHOTORECEPTOR DUAL CELL AGGREGATES AND METHODS OF USE THEREOF 审中-公开

公开(公告)号：US20230201267A1

公开(公告)日：2023-06-29

申请号：US18000071

申请日：2021-05-28

申请人： FUJIFILM Cellular Dynamics, Inc.

发明人： Andrew DIAS , Erich BERNDT , Lucas CHASE

IPC分类号： A61K35/30 , C12N5/0793 , C12N5/079 , G01N33/50 , A61P27/02

CPC分类号： A61K35/30 , C12N5/062 , C12N5/0621 , G01N33/5058 , A61P27/02 , C12N2501/727 , C12N2501/02 , C12N2500/33 , C12N2501/999 , C12N2502/083 , C12N2502/085

摘要： Provided herein is a dual cell aggregate culture of retinal epithelial cells and photoreceptors for use as a research tool, such as the screening of compounds or model for study of retinal diseases, as well as a therapeutic for treating ocular diseases.