公开(公告)号：US20230201267A1

公开(公告)日：2023-06-29

申请号：US18000071

申请日：2021-05-28

Applicant: FUJIFILM Cellular Dynamics, Inc.

Inventor： Andrew DIAS ,  Erich BERNDT ,  Lucas CHASE

IPC: A61K35/30 ,  C12N5/0793 ,  C12N5/079 ,  G01N33/50 ,  A61P27/02

CPC classification number: A61K35/30 ,  C12N5/062 ,  C12N5/0621 ,  G01N33/5058 ,  A61P27/02 ,  C12N2501/727 ,  C12N2501/02 ,  C12N2500/33 ,  C12N2501/999 ,  C12N2502/083 ,  C12N2502/085

Abstract: Provided herein is a dual cell aggregate culture of retinal epithelial cells and photoreceptors for use as a research tool, such as the screening of compounds or model for study of retinal diseases, as well as a therapeutic for treating ocular diseases.

公开(公告)号：US20230212509A1

公开(公告)日：2023-07-06

申请号：US18000008

申请日：2021-05-28

Applicant: FUJIFILM Cellular Dynamics, Inc. ,  The United States of America, as represented by the Secretary, Department of Health and Human Servic

Inventor： Andrew DIAS ,  Erich BERNDT ,  Lucas CHASE ,  Juan AMARAL ,  Arvydas MAMINISHKIS ,  Kapil BHARTI

IPC: C12N5/0793 ,  C12N5/079 ,  A61L27/36 ,  C12N5/00 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  A61L27/20 ,  A61L27/22 ,  A61L27/54

CPC classification number: C12N5/062 ,  A61L27/18 ,  A61L27/20 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L27/227 ,  A61L27/3641 ,  C12N5/0056 ,  C12N5/0621 ,  A61L2430/16 ,  C12N2533/40 ,  C12N2533/50 ,  C12N2533/90

Abstract: Provided herein are methods of producing a distinct bilayer culture of retinal epithelial cells (RPE) with photoreceptor cells and/or photoreceptor precursor cells (PR/PRP). Further provided herein is a therapy comprising transplantation of the RPE and PR/PRP bilayer as well as methods for testing candidate drugs using the bilayer.

公开(公告)号：US20250011714A1

公开(公告)日：2025-01-09

申请号：US18886115

申请日：2024-09-16

Applicant: FUJIFILM Cellular Dynamics, Inc.

Inventor： Nathan MEYER ,  Lucas CHASE ,  Casey STANKEWICZ

IPC: C12N5/00 ,  C12N5/079

Abstract: Provided herein are methods of enriching a retinal pigment epithelium (RPE) cell population derived from stem cells. Such a method may comprise removing contaminating cells through the depletion of CD24 positive cells, CD56 positive cells, and/or CD90 positive cells from a starting population of RPE cells.

公开(公告)号：US20220033770A1

公开(公告)日：2022-02-03

申请号：US17493533

申请日：2021-10-04

Applicant: FUJIFILM Cellular Dynamics, Inc.

Inventor： Nathan MEYER ,  Lucas CHASE ,  Casey STANKEWICZ

IPC: C12N5/00 ,  C12N5/079

Abstract: Provided herein are methods of enriching a retinal pigment epithelium (RPE) cell population derived from stem cells. Such a method may comprise removing contaminating cells through the depletion of CD24 positive cells, CD56 positive cells, and/or CD90 positive cells from a starting population of RPE cells.

公开(公告)号：US20240108501A1

公开(公告)日：2024-04-04

申请号：US18479052

申请日：2023-09-30

Applicant: FUJIFILM Cellular Dynamics, Inc.

Inventor： Tianran LIU ,  Randy LEARISH ,  Cayla THOMPSON ,  Matthew STERNFELD ,  Michael PHILLIPS ,  Virginia MATTIS ,  Lucas CHASE ,  Erik BROWN

IPC: A61F9/00 ,  A61K35/30

CPC classification number: A61F9/0017 ,  A61K35/30 ,  A61B2017/00969

Abstract: Provided for herein is a method of cell transplantation using an injection attachment having a hub containing a plurality of cells and a cannula extending from a distal end of the hub. The method includes orienting the injection attachment such that the cannula points downwardly until the plurality of cells settle together proximate the distal end, inserting the cannula into a tissue of a subject, and injecting the volume of cells into the tissue of the subject using the injection attachment.

公开(公告)号：US20210238546A1

公开(公告)日：2021-08-05

申请号：US17049018

申请日：2019-04-22

Applicant: FUJIFILM Cellular Dynamics, Inc.

Inventor： Lucas CHASE ,  Kyle WALLACE ,  Benjamin MELINE ,  Andrew DIAS ,  Brandon SHELLEY ,  Marisa FENN ,  Debjani PHILLIPS ,  Matthew STERNFELD ,  Nathan MEYER

IPC: C12N5/079 ,  A61K35/30 ,  C12N5/0793 ,  G01N33/68

Abstract: Provided herein are methods of producing a photoreceptor precursor (PRP) cell population derived from stem cells. Further provided herein are methods of using the PRP cell populations, such as for therapeutics.