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公开(公告)号：US20170253854A1
公开(公告)日：2017-09-07
申请号：US15447645
申请日：2017-03-02
发明人： Yiqin Du , Joel Steven Schuman
CPC分类号： C12N5/0621 , A61K9/0048 , A61K9/0051 , A61K35/28 , A61K35/30 , C12N2502/085 , C12N2502/1382 , C12N2506/1384 , C12N2533/90
摘要： A method of preparing a functional trabecular meshwork (TM) cell from adipose-derived stem cells is provided. Methods of treating glaucoma, implanting trabecular meshwork (TM) cells, or repairing or regenerating the aqueous outflow pathway of an eye of a patient also are provided.
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2.发明授权公开(公告)号：US09574171B2
公开(公告)日：2017-02-21
申请号：US13991172
申请日：2011-12-01
CPC分类号： A61K35/30 , C12N5/0062 , C12N5/0621 , C12N2501/11 , C12N2501/155 , C12N2501/33 , C12N2502/085 , C12N2502/1323 , C12N2506/02 , C12N2506/45 , C12N2533/52 , C12N2533/54 , C12N2533/90 , G01N33/5058 , G01N33/53
摘要： A method of generating a population of corneal epithelial cells is disclosed. The method comprises culturing human pluripotent stem cells in corneal fibroblast-conditioned medium on a solid surface comprising an extracellular matrix component thereby generating the population of corneal epithelial cells. Isolated cell populations and corneal tissues are also disclosed, as well as uses thereof.
摘要翻译： 公开了一种产生角膜上皮细胞群的方法。 该方法包括将角质成纤维细胞条件培养基中的人多能干细胞培养在包含细胞外基质组分的固体表面上，从而产生角膜上皮细胞群。 还公开了分离的细胞群和角膜组织，以及其用途。
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公开(公告)号：US20150175965A1
公开(公告)日：2015-06-25
申请号：US14405890
申请日：2013-12-12
发明人： Sophie Xiaohui Deng , Hua Mei , Martin Nakatsu , Sheyla Gonzalez
IPC分类号： C12N5/0797 , C12M1/00 , C12M1/12
CPC分类号： C12N5/0621 , C12M23/04 , C12M23/34 , C12M29/04 , C12N5/0663 , C12N5/0667 , C12N2501/415 , C12N2501/42 , C12N2502/085 , C12N2506/09 , C12N2513/00
摘要： The invention disclosed herein provides systems and methods designed to facilitate human limbal stem/progenitor cell culture including a novel 3-dimensional (3D) sandwich method/system in which human limbal stem/progenitor cells and feeder cells are separately cultured on opposite sides of a porous membrane.
摘要翻译： 本文公开的本发明提供了设计用于促进人角膜缘干/祖细胞培养的系统和方法，包括新颖的三维（3D）夹心方法/系统，其中将人角膜缘干/祖细胞和饲养细胞分别培养在 多孔膜。
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4.发明申请公开(公告)号：US20130251692A1
公开(公告)日：2013-09-26
申请号：US13991172
申请日：2011-12-01
IPC分类号： C12N5/00
CPC分类号： A61K35/30 , C12N5/0062 , C12N5/0621 , C12N2501/11 , C12N2501/155 , C12N2501/33 , C12N2502/085 , C12N2502/1323 , C12N2506/02 , C12N2506/45 , C12N2533/52 , C12N2533/54 , C12N2533/90 , G01N33/5058 , G01N33/53
摘要： A method of generating a population of corneal epithelial cells is disclosed. The method comprises culturing human pluripotent stem cells in corneal fibroblast-conditioned medium on a solid surface comprising an extracellular matrix component thereby generating the population of corneal epithelial cells. Isolated cell populations and corneal tissues are also disclosed, as well as uses thereof.
摘要翻译： 公开了一种产生角膜上皮细胞群的方法。 该方法包括将角质成纤维细胞条件培养基中的人多能干细胞培养在包含细胞外基质组分的固体表面上，从而产生角膜上皮细胞群。 还公开了分离的细胞群和角膜组织，以及其用途。
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公开(公告)号：US20120237473A1
公开(公告)日：2012-09-20
申请号：US13420502
申请日：2012-03-14
申请人： Anton Kolomeyer , Ilene Sugino , Marco Zarbin
发明人： Anton Kolomeyer , Ilene Sugino , Marco Zarbin
IPC分类号： A61K38/18 , A61K38/17 , A61K38/30 , C12N5/071 , A61P27/06 , C12Q1/02 , C12Q1/32 , G01N33/566 , A61K38/19 , A61P27/02
CPC分类号： C12N5/062 , A61K38/1833 , A61K38/57 , C12N2502/085 , G01N33/5005 , G01N2333/71 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions comprising trophic factors, methods to decrease the degeneration of a retina, methods of treating ocular degenerative diseases and methods to select cells for transplantation.
摘要翻译： 本发明涉及包含营养因子的药物组合物，减少视网膜变性的方法，治疗眼变性疾病的方法和选择用于移植的细胞的方法。
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公开(公告)号：US20160376555A1
公开(公告)日：2016-12-29
申请号：US15195748
申请日：2016-06-28
发明人： Sophie Xiaohui Deng , Hua Mei , Martin Nakatsu , Sheyla Gonzalez
IPC分类号： C12N5/0797 , C12N5/079
CPC分类号： C12N5/0621 , C12M23/04 , C12M23/34 , C12M29/04 , C12N5/0663 , C12N5/0667 , C12N2501/415 , C12N2501/42 , C12N2502/085 , C12N2506/09 , C12N2513/00
摘要： The invention disclosed herein provides systems and methods designed to facilitate human limbal stem/progenitor cell culture including a novel 3-dimensional (3D) sandwich method/system in which human limbal stem/progenitor cells and feeder cells are separately cultured on opposite sides of a porous membrane.
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公开(公告)号：US20120196281A1
公开(公告)日：2012-08-02
申请号：US13498619
申请日：2010-09-28
申请人： Volker Busskamp , Jens Duebel , Serge Picaud , Botond Roska , José Alain Sahel
发明人： Volker Busskamp , Jens Duebel , Serge Picaud , Botond Roska , José Alain Sahel
CPC分类号： C12N5/062 , C12N5/0697 , C12N2502/085 , C12N2502/99 , C12N2503/04 , C12N2510/00 , G01N33/5082 , G01N2500/10 , G01N2800/164
摘要： The present invention provides an organotypic system comprising a portion of a retina containing live cells in a cultured in medium, wherein photosensitivity has been restored in at least some of said live cells. Methods of use thereof are also provided.
摘要翻译： 本发明提供了包含在培养基中含有活细胞的视网膜的一部分的器官型系统，其中在至少一些所述活细胞中已恢复光敏性。 还提供了其使用方法。
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8.发明申请Method And Composition For The Treatment Of Moderate To Severe Keratoconjunctivitis Sicca 审中-公开治疗中度至重度角膜结膜炎的方法和组成公开(公告)号：US20110300097A1
公开(公告)日：2011-12-08
申请号：US12793927
申请日：2010-06-04
申请人： Ahmed H. Al-Qahtani
发明人： Ahmed H. Al-Qahtani
CPC分类号： A61K38/2086 , A45C11/005 , A61K9/0048 , A61K31/07 , A61K31/165 , A61K31/19 , A61K31/341 , A61K31/351 , A61K31/382 , A61K31/4178 , A61K31/7036 , A61K33/10 , A61K33/14 , A61K35/30 , A61K38/12 , A61K38/1735 , A61K38/1793 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/19 , A61K38/191 , A61K38/193 , A61K38/195 , A61K38/2006 , A61K38/2013 , A61K38/2026 , A61K38/204 , A61K38/2046 , A61K38/2053 , A61K47/183 , A61K47/38 , C12N5/0621 , C12N2500/84 , C12N2501/734 , C12N2501/999 , C12N2502/085 , C12Y304/21004 , A61K2300/00
摘要： The present invention relates to topical ophthalmic compositions for treating or preventing epithelial lesions or ophthalmic disorders, including dry eye or keratoconjunctivitis sicca.
摘要翻译： 本发明涉及用于治疗或预防上皮损伤或眼科疾病的局部用眼用组合物，其包括干眼症或角结膜结膜炎。
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公开(公告)号：US5827641A
公开(公告)日：1998-10-27
申请号：US337830
申请日：1994-11-08
CPC分类号： C12N5/0698 , A61F2/14 , A61F2/142 , A61K35/12 , A61L27/3804 , A61L27/3808 , A61L27/3813 , A61L27/3839 , A61L27/3891 , A61L27/3895 , C12N5/0621 , C12N5/069 , C12N5/0697 , A61L2430/16 , C12N2500/25 , C12N2500/90 , C12N2501/39 , C12N2501/395 , C12N2502/085 , C12N2502/094 , C12N2502/1323 , C12N2502/28 , C12N2510/04
摘要： This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an in vitro model of the eye, which can be used for transplantation or implantation in vivo or for screening compounds in vitro. This invention is also directed to the use of endothelial cells in other tissue and organ equivalents to promote basement membrane development. The cornea equivalent comprises an inner endothelial cell layer, a middle stromal cell and collagen mixture wherein the stromal cells are derived from fibroblast cells and an external epithelial cell layer, wherein the epithelial cells are derived from corneal epithelial cells.
摘要翻译： 本发明涉及使用组织培养系统制造的眼睛的角膜部分的器官当量。 构建角膜等价物的方法产生类似于眼内角膜的结构。 角膜等效物是眼的体外模型，其可用于体内移植或植入或用于体外筛选化合物。 本发明还涉及内皮细胞在其他组织和器官等同物中用于促进基底膜发育的用途。 角膜等效物包括内部内皮细胞层，中间基质细胞和胶原混合物，其中基质细胞衍生自成纤维细胞和外部上皮细胞层，其中上皮细胞衍生自角膜上皮细胞。
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公开(公告)号：US11944720B2
公开(公告)日：2024-04-02
申请号：US16980120
申请日：2019-03-12
CPC分类号： A61L27/3834 , A61L27/3813 , A61L27/3869 , A61L27/52 , C12M21/08 , C12M23/06 , C12M23/38 , C12M25/04 , C12N5/0606 , C12N5/0621 , C12N5/069 , C12N5/0697 , A61L2400/06 , A61L2430/16 , C12N2502/02 , C12N2502/085 , C12N2502/28
摘要： Disclosed is a method for preparing an implant including a culture of cells on a membrane, the method including steps that consist of: securing the membrane to a mounting; placing the membrane in a recess of a housing providing two spaces having adjusted heights, above and below the membrane; injecting, into the spaces, a liquid capable of transforming into gel at a transport temperature lower than an injection temperature of the liquid; and bringing the housing to the transport temperature, so as to form an implant including the membrane and two layers of gel having adjusted thicknesses, on two opposite faces of the membrane, respectively.
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