公开(公告)号：US20210121499A1

公开(公告)日：2021-04-29

申请号：US17139370

申请日：2020-12-31

申请人： FUJIFILM Corporation ,  Kyowa Kirin Co., Ltd.

发明人： Shinsuke TOKUOKA ,  Hayato YOSHIDA ,  Yuichiro KONDO

IPC分类号： A61K31/785 ,  A61P7/08 ,  A61K9/14 ,  A61K47/38

摘要： The object of the present invention is to provide a therapeutic agent for hyperphosphatemia capable sufficiently decreasing a serum phosphorus concentration with a small dose, and particles therefor. The present invention provides a therapeutic agent for hyperphosphatemia, which comprises, as an active ingredient, a particle containing a crosslinked polymer having a substituent containing a NRA1RA2 structure or a salt thereof, wherein the particle has an average particle diameter of 20 to 150 μm and a swelling rate of 9 to 16 mL/g (wherein RA1 and RA2 each independently represent a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aminoalkyl group having 1 to 20 carbon atoms or a salt thereof, or the like).

公开(公告)号：US20240157329A1

公开(公告)日：2024-05-16

申请号：US18531833

申请日：2023-12-07

申请人： FUJIFILM Corporation

发明人： Shinsuke TOKUOKA ,  Shigeki UEHIRA ,  Masato SENOO ,  Koji HIRONAKA

IPC分类号： B01J20/26 ,  B01J20/287

CPC分类号： B01J20/262 ,  B01J20/287 ,  B01J2220/50

摘要： A polymer that contains, in a molecular chain constituting a main chain, a skeleton derived from a dehydroabietic acid compound, an adsorbent that contains the polymer, and an adsorption apparatus that has the adsorbent.

公开(公告)号：US20190321393A1

公开(公告)日：2019-10-24

申请号：US16457338

申请日：2019-06-28

申请人： FUJIFILM Corporation ,  Kyowa Hakko Kirin Co., Ltd.

发明人： Shinsuke TOKUOKA ,  Hayato YOSHIDA ,  Yuichiro KONDO

IPC分类号： A61K31/785 ,  A61K9/14 ,  A61K47/38 ,  A61P7/08

摘要： The object of the present invention is to provide a therapeutic agent for hyperphosphatemia capable sufficiently decreasing a serum phosphorus concentration with a small dose, and particles therefor. The present invention provides a therapeutic agent for hyperphosphatemia, which comprises, as an active ingredient, a particle containing a crosslinked polymer having a substituent containing a NRA1RA2 structure or a salt thereof, wherein the particle has an average particle diameter of 20 to 150 μm and a swelling rate of 9 to 16 mL/g (wherein RA1 and RA2 each independently represent a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aminoalkyl group having 1 to 20 carbon atoms or a salt thereof, or the like).

公开(公告)号：US20190321392A1

公开(公告)日：2019-10-24

申请号：US16456822

申请日：2019-06-28

申请人： FUJIFILM Corporation ,  Kyowa Hakko Kirin Co., Ltd.

发明人： Shinsuke TOKUOKA ,  Hayato YOSHIDA ,  Yuichiro KONDO

IPC分类号： A61K31/785

摘要： The object of the present invention is to provide a therapeutic agent for hyperphosphatemia capable sufficiently decreasing a serum phosphorus concentration with a small dose. The present invention provides a therapeutic agent for hyperphosphatemia, which comprises, as an active ingredient, a particle containing certain crosslinked polymer (preferably crosslinked polyallylamine).

公开(公告)号：US20190315932A1

公开(公告)日：2019-10-17

申请号：US16455091

申请日：2019-06-27

申请人： FUJIFILM Corporation

发明人： Shinsuke TOKUOKA ,  Hayato YOSHIDA ,  Katsuhiro SHIMONO ,  Takayuki ITO

IPC分类号： C08J3/09 ,  C08L1/26 ,  C08K5/00 ,  B29B9/12 ,  C08J3/24

摘要： Provided are an emulsion of a nitrogen atom-containing polymer or a salt thereof, the emulsion having high emulsion stability and having a low dispersity of the particle diameter of emulsified particles, and a method for producing the emulsion. Also provided is a method for producing particles including a crosslinked nitrogen atom-containing polymer or a salt thereof by using the emulsion described above. Disclosed is a method for producing an emulsion of a nitrogen atom-containing polymer or a salt thereof, the method including a step of mixing a first solution that includes a nitrogen atom-containing polymer or a salt thereof and a hydrophilic solvent and has a viscosity of 10 to 2,000 mPa·s, and a second solution that includes a hydrophobic solvent and has a viscosity of 1 to 100 mPa·s, stirring the mixture, and thus obtaining an emulsion of the nitrogen atom-containing polymer or a salt thereof, wherein a ratio between the viscosity of the first solution and the viscosity of the second solution is in a range of 0.1:1 to 300:1.

公开(公告)号：US20160355662A1

公开(公告)日：2016-12-08

申请号：US15238723

申请日：2016-08-17

申请人： FUJIFILM CORPORATION

发明人： Shinsuke TOKUOKA ,  Ritsuko HORI

IPC分类号： C08J9/28 ,  C08B16/00 ,  C08B1/00

CPC分类号： C08J9/28 ,  C08B1/003 ,  C08B15/10 ,  C08B16/00 ,  C08J2201/0546 ,  C08J2301/00 ,  C08J2301/02

摘要： Provided are a method of manufacturing porous cellulose particles, including a cellulose solution preparation step of preparing a cellulose solution by dissolving cellulose in an aqueous lithium bromide solution, a dispersion preparation step of preparing a cellulose solution dispersion by dispersing the cellulose solution in an organic dispersion medium, and a coagulation step of coagulating cellulose in the cellulose solution dispersion by cooling the cellulose solution dispersion and adding a coagulation solvent thereto such that porous particles are obtained, and porous cellulose particles obtained by the method for manufacturing porous cellulose particles.

摘要翻译： 提供一种制造多孔纤维素颗粒的方法，包括通过将纤维素溶解在溴化锂水溶液中制备纤维素溶液的纤维素溶液制备步骤，通过将纤维素溶液分散在有机分散体中制备纤维素溶液分散体的分散体制备步骤 介质和凝固步骤，通过冷却纤维素溶液分散体并在其中加入凝固溶剂使得得到多孔颗粒，以及通过制造多孔纤维素颗粒的方法获得的多孔纤维素颗粒，将纤维素凝结在纤维素溶液分散体中。