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    Process for producing farnesylated dibenzodiazepinone by fermentation
    1.
    发明申请
    Process for producing farnesylated dibenzodiazepinone by fermentation 审中-公开
    通过发酵生产法呢基化二苯并二氮杂酮的方法

    公开(公告)号：US20070254346A1

    公开(公告)日：2007-11-01

    申请号：US11785226

    申请日：2007-04-16

    申请人： Faustinus Yeboah ,  Mahmood Piraee

    发明人： Faustinus Yeboah ,  Mahmood Piraee

    IPC分类号： C12P17/00 ,  C07D243/10

    CPC分类号： C12P17/10 ,  B01D15/00 ,  B01D61/145 ,  C07D243/38 ,  C12N1/20 ,  C12P17/12 ,  C12R1/29

    摘要： The present invention provides a scalable process for producing a concentrate containing a mass of a farnesylated dibenzodiazepinone by fermenting in an aqueous culture medium a strain of a microorganism that is capable of producing the farnesylated dibenzodiazepinone, upon completion of fermentation harvesting the fermentation broth and extracting the fermentation broth to provide an extract, and thereafter treating the extract to form the concentrate. The concentrate so produced may be utilized in downstream processes for producing pharmaceutical compounds. A strain of a Micromonospora species capable of producing a farnesylated dibenzodiazepinone at a high yield rate is provided, together with culture media for culturing microorganisms, and fermentation conditions for production of the farnesylated dibenzodiazepinone of the concentrate.

    摘要翻译： 本发明提供了一种可扩展的方法，用于生产含有大量法呢基化二苯并二氮杂酮的浓缩物，其通过在水性培养基中发酵能够产生法呢基化二苯并二氮杂酮的微生物菌株，在完成发酵收获发酵液并提取 发酵液提供提取物，然后处理提取物以形成浓缩物。 如此生产的浓缩物可用于生产药物化合物的下游方法。 提供能够以高产率生产法呢基化二苯并二氮杂酮的小单孢菌属菌株，以及用于培养微生物的培养基和用于生产浓缩物的法呢基化二苯并二氮杂酮的发酵条件。

    Process for producing farnesylated dibenzodiazepinone by fermentation
    2.
    发明授权
    Process for producing farnesylated dibenzodiazepinone by fermentation 有权
    通过发酵生产法呢基化二苯并二氮杂酮的方法

    公开(公告)号：US08361759B2

    公开(公告)日：2013-01-29

    申请号：US12764537

    申请日：2010-04-21

    申请人： Faustinus Yeboah ,  Mahmood Piraee

    发明人： Faustinus Yeboah ,  Mahmood Piraee

    IPC分类号： C12P17/10

    CPC分类号： C12P17/10 ,  B01D15/00 ,  B01D61/145 ,  C07D243/38 ,  C12N1/20 ,  C12P17/12 ,  C12R1/29

    摘要： The present invention provides a scalable process for producing a concentrate containing a mass of a farnesylated dibenzodiazepinone by fermenting in an aqueous culture medium a strain of a microorganism that is capable of producing the farnesylated dibenzodiazepinone, upon completion of fermentation harvesting the fermentation broth and extracting the fermentation broth to provide an extract, and thereafter treating the extract to form the concentrate. The concentrate so produced may be utilized in downstream processes for producing pharmaceutical compounds. A strain of a Micromonospora species capable of producing a farnesylated dibenzodiazepinone at a high yield rate is provided, together with culture media for culturing microorganisms, and fermentation conditions for production of the farnesylated dibenzodiazepinone of the concentrate.

    摘要翻译： 本发明提供了一种可扩展的方法，用于生产含有大量法呢基化二苯并二氮杂酮的浓缩物，其通过在水性培养基中发酵能够产生法呢基化二苯并二氮杂酮的微生物菌株，在完成发酵收获发酵液并提取 发酵液提供提取物，然后处理提取物以形成浓缩物。 如此生产的浓缩物可用于生产药物化合物的下游方法。 提供能够以高产率生产法呢基化二苯并二氮杂酮的小单孢菌属菌株，以及用于培养微生物的培养基和用于生产浓缩物的法呢基化二苯并二氮杂酮的发酵条件。

    Preparation, characterization and quantification of active fractions that promote cell growth and recombinant-protein expression
    3.
    发明申请
    Preparation, characterization and quantification of active fractions that promote cell growth and recombinant-protein expression 审中-公开
    促进细胞生长和重组蛋白表达的活性级分的制备，表征和定量

    公开(公告)号：US20050250177A1

    公开(公告)日：2005-11-10

    申请号：US10637017

    申请日：2003-08-07

    申请人： Faustinus Yeboah ,  Barbara Jardin ,  Yasuo Konishi ,  Amine Kamen ,  Tin Wong ,  Soo Lee

    发明人： Faustinus Yeboah ,  Barbara Jardin ,  Yasuo Konishi ,  Amine Kamen ,  Tin Wong ,  Soo Lee

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N5/06 ,  C12P21/06

    CPC分类号： C12N5/0018 ,  C12N2500/70 ,  C12N2500/74 ,  C12N2500/92

    摘要： A process for preparing an active animal cell-growth-enhancing fraction of a hydrolysate of plant tissue, animal tissue or microorganism ultrafiltrate material, especially a fraction of a yeastolate ultrafiltrate, comprising forming a precipitate from said fraction with a water-soluble solvent is disclosed. Such solvents as alkanols, alkyl sulfoxides, ketones or alkyl nitriles, especially lower (C1-C5) alkanols, particularly ethanol, can be used. The invention also relates to an active animal cell-growth-enhancing fraction of a hydrolysate of plant tissue, animal tissue or microorganism ultrafiltrate material, especially a fraction of a yeastolate ultrafiltrate, substantially free of aromatic and methyl group bearing compounds which has improved cell-growth-enhancing properties.

    摘要翻译： 公开了一种用于制备植物组织，动物组织或微生物超滤液物质的水解产物的活性动物细胞生长增强部分的方法，特别是酵母醇酯超级滤液的一部分，包括用水溶性溶剂从所述级分形成沉淀物 。 可以使用诸如链烷醇，烷基亚砜，酮或烷基腈，特别是较低（C 1 -C 5 -C 5）烷醇，特别是乙醇的溶剂。 本发明还涉及植物组织，动物组织或微生物超滤液物质的水解产物的活性动物细胞生长增强级分，特别是基本上不含芳香族和甲基基团化合物的酵母醇酯超级滤液的一部分， 生长增强性能。