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公开(公告)号：US20220002818A1
公开(公告)日：2022-01-06
申请号：US17377231
申请日：2021-07-15
Applicant: Foundation Medicine, Inc.
Inventor： Maureen T. CRONIN , Doron LIPSON , Roman YELENSKY
IPC: C12Q1/6886 , C07K14/47 , C12N9/12 , A61K31/4545 , C07K16/40 , G01N33/50 , G01N33/574
Abstract: Novel ALK and NTRK1 fusion molecules and uses are disclosed.
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公开(公告)号：US20240360199A1
公开(公告)日：2024-10-31
申请号：US18651604
申请日：2024-04-30
Applicant: Foundation Medicine, Inc.
Inventor： Doron LIPSON , Roman YELENSKY , Joel Robert GREENBOWE , Jie HE
CPC classification number: C07K14/71 , C07K14/47 , C07K16/18 , C07K16/2863 , C07K16/40 , C12N9/96 , C12N15/62
Abstract: Novel fusion molecules and uses are disclosed.
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公开(公告)号：US20240288430A1
公开(公告)日：2024-08-29
申请号：US18513107
申请日：2023-11-17
Applicant: Genentech, Inc. , Foundation Medicine, Inc.
Inventor： Craig Anthony CUMMINGS , Yan LI , Sarah Margaret SHAGAN , Erica Beth SCHLEIFMAN , David SHAMES , David FABRIZIO , Daniel LIEBER , Geoffrey Alan OTTO , Mark KENNEDY , Travis CLARK , Doron LIPSON , Jie HE , Shan ZHONG
IPC: G01N33/574 , A61K39/00 , A61P35/00 , C07K14/735 , C07K16/28 , C12Q1/68 , C12Q1/6883 , G06F16/28 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70
CPC classification number: G01N33/574 , A61P35/00 , C07K14/70535 , C07K16/2827 , C07K16/2896 , C12Q1/68 , C12Q1/6883 , G01N33/57492 , G06F16/285 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70 , A61K2039/505 , A61K2039/55 , C07K2317/24 , C12Q2600/156 , G01N2333/70532 , G01N2800/52
Abstract: The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.
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公开(公告)号：US20230148412A1
公开(公告)日：2023-05-11
申请号：US17812415
申请日：2022-07-13
Applicant: Foundation Medicine, Inc.
Inventor： Doron LIPSON , Geoffrey Alan OTTO , Alexander Nevin PARKER , Philip James STEPHENS , Sean R. DOWNING , Mirna JAROSZ , Mikhail G. SHAPIRO , Roman YELENSKY
IPC: C12Q1/6827 , C12Q1/6874 , G16B20/10 , G16B30/10 , G16B20/20 , G16B20/00 , G16B30/00
CPC classification number: C12Q1/6827 , C12Q1/6874 , G16B20/10 , G16B30/10 , G16B20/20 , G16B20/00 , G16B30/00 , C12Q1/6886
Abstract: A method of analyzing a tumor sample comprising:
(a) acquiring a library comprising a plurality of tumor members from a tumor sample;
(b) contacting the library with a bait set to provide selected members;
(c) acquiring a read for a subgenomic interval from a tumor member from said library;
(d) aligning said read; and
(e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.-
公开(公告)号：US20240327926A1
公开(公告)日：2024-10-03
申请号：US18607277
申请日：2024-03-15
Applicant: Foundation Medicine, Inc.
Inventor： Geoffrey Alan OTTO , Michelle NAHAS , Doron LIPSON
IPC: C12Q1/6886 , C12N15/10 , C12Q1/6806 , G16B25/00 , G16B25/10 , G16B30/00 , G16B30/10 , G16B45/00
CPC classification number: C12Q1/6886 , C12N15/1065 , C12Q1/6806 , G16B25/00 , G16B25/10 , G16B30/00 , G16B30/10 , G16B45/00 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
Abstract: Methods of evaluating or providing a clonal profile of a subject interval, e.g., a subgenomic interval, or an expressed subgenomic interval (or of a cell containing the same), in a subject, are disclosed.
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Patent Agency Ranking
公开(公告)号：US20230372338A1
公开(公告)日：2023-11-23
申请号：US18346029
申请日：2023-06-30
Applicant: Foundation Medicine, Inc.
Inventor： Siraj Mahamed ALI , Matthew J. HAWRYLUK , Jie HE , Doron LIPSON , Vincent A. MILLER , Jeffrey S. ROSS , Philip James STEPHENS
IPC: A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/498 , A61K31/496 , A61K31/517 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C07K16/40 , C12N15/113 , C12Q1/6883 , G01N33/573
CPC classification number: A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/498 , A61K31/496 , A61K31/517 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C12Y207/10001 , C07K16/40 , C12N15/1137 , C12Q1/6883 , G01N33/573 , C12Q2600/156 , C07K2319/00 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Q2600/158 , G01N2333/912 , G01N2500/04
Abstract: Methods and compositions for treating cholangiocarcinoma.
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公开(公告)号：US20220251667A1
公开(公告)日：2022-08-11
申请号：US17673718
申请日：2022-02-16
Applicant: Foundation Medicine, Inc.
Inventor： Maureen T. CRONIN , Garrett Michael FRAMPTON , Doron LIPSON , Vincent A. MILLER , Gary PALMER , Jeffrey S. ROSS , Philip James STEPHENS , Roman YELENSKY
IPC: C12Q1/6886 , A61K31/565 , A61K31/4196 , A61K31/675 , A61K31/439 , A61K31/567 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/472 , A61K31/536 , A61K31/5415 , A61K45/06 , C07K14/72 , C07K16/28 , A61K31/436
Abstract: Novel mutant ESR1 molecules and uses are disclosed.
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公开(公告)号：US20220169703A1
公开(公告)日：2022-06-02
申请号：US17539023
申请日：2021-11-30
Applicant: Foundation Medicine, Inc.
Inventor： Doron LIPSON , Roman YELENSKY , Joel Robert GREENBOWE , Jie HE
Abstract: Novel fusion molecules and uses are disclosed.
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公开(公告)号：US20230241065A1
公开(公告)日：2023-08-03
申请号：US17817619
申请日：2022-08-04
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Sean R. DOWNING , Matthew J. HAWRYLUK , Doron LIPSON , Alexander N. PARKER , Philip James STEPHENS
IPC: A61K31/517 , C07K14/82 , C12N9/14 , C12Q1/6886 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/47 , A61K31/513 , C12N15/113
CPC classification number: A61K31/517 , A61K31/47 , A61K31/404 , A61K31/444 , A61K31/513 , A61K31/4412 , C07K14/82 , C12N9/14 , C12N15/1135 , C12Q1/6886 , C07K2319/00 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
Abstract: Novel RET fusion molecules and uses are disclosed.
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公开(公告)号：US20210283134A1
公开(公告)日：2021-09-16
申请号：US17204830
申请日：2021-03-17
Applicant: Foundation Medicine, Inc.
Inventor： Siraj Mahamed ALI , Matthew J. HAWRYLUK , Jie HE , Doron LIPSON , Vincent A. MILLER , Jeffrey S. ROSS , Philip James STEPHENS
IPC: A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/498 , A61K31/496 , A61K31/517 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C07K16/40 , C12N15/113 , C12Q1/6883 , G01N33/573
Abstract: Methods and compositions for treating cholangiocarcinoma.
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