-
公开(公告)号：US09284298B2
公开(公告)日：2016-03-15
申请号：US14110596
申请日：2012-04-03
申请人： Francesco Casuscelli , Maria Gabriella Brasca , Marina Caldarelli , Giovanni Cervi , Teresa Disingrini , Francesca Quartieri
发明人： Francesco Casuscelli , Maria Gabriella Brasca , Marina Caldarelli , Giovanni Cervi , Teresa Disingrini , Francesca Quartieri
IPC分类号： A61K45/06 , A61K31/506 , C07D403/04 , C07D401/14 , C07D403/14 , C07D413/14
CPC分类号： C07D403/04 , A61K31/506 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14
摘要： The present invention relates to pyrazolyl-pyrimidine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及调节蛋白激酶活性的吡唑基 - 嘧啶衍生物，因此可用于治疗由失调的蛋白激酶活性引起的疾病。 本发明还提供了制备这些化合物的方法，包含这些化合物的药物组合物，以及使用这些化合物治疗疾病的方法或含有它们的药物组合物。
-
公开(公告)号：US20140051708A1
公开(公告)日：2014-02-20
申请号：US14110596
申请日：2012-04-03
申请人： Francesco Casuscelli , Maria Gabriella Brasca , Marina Caldarelli , Giovanni Cervi , Teresa Disingrini , Francesca Quartieri
发明人： Francesco Casuscelli , Maria Gabriella Brasca , Marina Caldarelli , Giovanni Cervi , Teresa Disingrini , Francesca Quartieri
IPC分类号： C07D403/04 , A61K45/06 , C07D401/14 , A61K31/506
CPC分类号： C07D403/04 , A61K31/506 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14
摘要： The present invention relates to pyrazolyl-pyrimidine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及调节蛋白激酶活性的吡唑基 - 嘧啶衍生物，因此可用于治疗由失调的蛋白激酶活性引起的疾病。 本发明还提供了制备这些化合物的方法，包含这些化合物的药物组合物，以及使用这些化合物治疗疾病的方法或含有它们的药物组合物。
-
3.发明授权Tricyclic derivatives, process for their preparation and their use as kinase inhibitors 有权三环衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US08916577B2
公开(公告)日：2014-12-23
申请号：US13980182
申请日：2012-01-19
申请人： Marina Caldarelli , Francesco Casuscelli , Daniele Donati , Danilo Mirizzi , Francesca Quartieri , Marco Silvagni
发明人： Marina Caldarelli , Francesco Casuscelli , Daniele Donati , Danilo Mirizzi , Francesca Quartieri , Marco Silvagni
IPC分类号： A61K45/06 , A61K31/551 , C07D498/14 , C07D498/04 , C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/5383
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K45/06 , C07D498/04 , C07D498/14
摘要： New substituted tricyclic compounds of formula (I) are described, wherein R1, R2, X, Y, Z are herein defined, having protein kinase inhibiting activity. The invention includes methods to prepare the compounds of formula (I), pharmaceutical compositions containing them, and their use in therapy, in particular for the treatment of diseases caused by and/or associated with dysregulated activity of protein kinase.
摘要翻译： 描述了式（I）的新取代的三环化合物，其中R1，R2，X，Y，Z在本文中定义，具有蛋白激酶抑制活性。 本发明包括制备式（I）化合物，含有它们的药物组合物的方法及其在治疗中的用途，特别是用于治疗由蛋白激酶失调的活性引起的和/或与之有关的疾病。
-
4.发明申请TRICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权三肽衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US20130302416A1
公开(公告)日：2013-11-14
申请号：US13980182
申请日：2012-01-19
申请人： Marina Caldarelli , Francesco Casuscelli , Daniele Donati , Danilo Mirizzi , Francesca Quartieri , Marco Silvagni
发明人： Marina Caldarelli , Francesco Casuscelli , Daniele Donati , Danilo Mirizzi , Francesca Quartieri , Marco Silvagni
IPC分类号： C07D487/04 , C07D498/04 , A61K45/06 , A61K31/551 , C07D498/14 , A61K31/5383 , A61K31/519 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K45/06 , C07D498/04 , C07D498/14
摘要： New substituted tricyclic compounds of formula (I) are described, wherein R1, R2, X, Y, Z are herein defined, having protein kinase inhibiting activity. The invention includes methods to prepare the compounds of formula (I), pharmaceutical compositions containing them, and their use in therapy, in particular for the treatment of diseases caused by and/or associated with dysregulated activity of protein kinase.
摘要翻译： 描述了式（I）的新取代的三环化合物，其中R1，R2，X，Y，Z在本文中定义，具有蛋白激酶抑制活性。 本发明包括制备式（I）化合物，含有它们的药物组合物的方法及其在治疗中的用途，特别是用于治疗由蛋白激酶失调的活性引起的和/或与之有关的疾病。
-
5.发明申请公开(公告)号：US20130338148A1
公开(公告)日：2013-12-19
申请号：US13972659
申请日：2013-08-21
申请人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： A61K31/551 , C07D401/10 , C07D487/14 , A61K31/519 , A61K31/5377 , C07D231/56 , C07D487/04
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
-
6.发明授权Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors 有权吡唑并喹唑啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US07482354B2
公开(公告)日：2009-01-27
申请号：US10557565
申请日：2004-04-27
申请人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： A61K31/505 , A01N43/54 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
-
7.发明授权Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors 有权吡唑并喹唑啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US08981089B2
公开(公告)日：2015-03-17
申请号：US13972659
申请日：2013-08-21
申请人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： C07D487/04 , C07D403/14 , C07D413/14 , C07D487/14 , C07D231/56 , C07D239/72
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
-
8.发明授权Pyrazolo quinazoline derivatives, process for their preparation and their use as kinase inhibitors 有权吡唑喹啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US08541429B2
公开(公告)日：2013-09-24
申请号：US12262933
申请日：2008-10-31
申请人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
-
9.发明申请Pyrazolo-Quinazoline Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors 有权吡唑并喹唑啉衍生物，其制备方法及其用作激酶抑制剂公开(公告)号：US20090124605A1
公开(公告)日：2009-05-14
申请号：US12262933
申请日：2008-10-31
申请人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： A61K31/551 , A61K31/519 , C12N9/99 , C07D487/04 , A61K31/496 , A61P25/28 , A61P17/06 , A61P37/06 , A61P37/00 , A61P35/00 , C07D401/14 , C07D413/14 , A61K31/5377
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
-
10.发明授权N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as MPS1 kinase inhibitors 有权作为MPS1激酶抑制剂的N-芳基-2-（2-芳基氨基嘧啶-4-基）吡咯-4-甲酰胺衍生物公开(公告)号：US08772280B2
公开(公告)日：2014-07-08
申请号：US13260665
申请日：2010-03-23
IPC分类号： A61K31/55 , A61K31/497 , A61K31/505 , C07D243/08 , C07D403/04 , C07D401/04
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14
摘要： The present invention relates to substituted pyrrolyl-pyrimidines which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及调节蛋白激酶活性的取代吡咯基嘧啶，因此可用于治疗由失调蛋白激酶活性引起的疾病，特别是MPS1。 本发明还提供了制备这些化合物的方法，包含这些化合物的药物组合物，以及使用这些化合物治疗疾病的方法或含有它们的药物组合物的方法。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.04 秒)
