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公开(公告)号：US5175318A
公开(公告)日：1992-12-29
申请号：US866108
申请日：1992-04-07
申请人： Francesco Minisci , Attilio Citterio , Elena Vismara , Silvia De Bernardinis , Carlo Neri , Luciano Pallini , Mariano Correale
发明人： Francesco Minisci , Attilio Citterio , Elena Vismara , Silvia De Bernardinis , Carlo Neri , Luciano Pallini , Mariano Correale
摘要： Phenols are oxidated to quinones with hydrogen peroxide in the presence of catalytic amounts of bromine, iodine, hydrogen bromide and hydrogen iodide.
摘要翻译： 在催化量的溴，碘，溴化氢和碘化氢的存在下，苯酚用过氧化氢氧化成醌。
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2.发明授权Multistep process for the physical depolymerization of heparin and products obtained therefrom 有权用于肝素物理解聚和由其获得的产物的多步法公开(公告)号：US07939512B2
公开(公告)日：2011-05-10
申请号：US11279699
申请日：2006-04-13
申请人： Luigi De Ambrosi , Sergio Gonella , Donata Bensi , Giangiacomo Torri , Antonella Bisio , Elena Vismara
发明人： Luigi De Ambrosi , Sergio Gonella , Donata Bensi , Giangiacomo Torri , Antonella Bisio , Elena Vismara
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： C08B37/0078
摘要： The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two γ-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.
摘要翻译： 本发明涉及用于肝素物理解聚的多步骤方法，其中肝素进行至少两次γ射线照射，并且其中在两个照射步骤之间进行解聚的肝素进行分离步骤，并且仅将解聚的肝素的一部分 从第一次照射得到的第二照射工序。 还涉及通过本发明的方法获得的肝素衍生的寡糖级分。
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公开(公告)号：US07754878B2
公开(公告)日：2010-07-13
申请号：US10506619
申请日：2003-03-20
申请人： Giangiacomo Torri , Angelo Alberti , Sabrina Bertini , Gianluca Ciardelli , Giuseppe Gastaldi , Solitario Nesti , Elena Vismara
发明人： Giangiacomo Torri , Angelo Alberti , Sabrina Bertini , Gianluca Ciardelli , Giuseppe Gastaldi , Solitario Nesti , Elena Vismara
摘要： Polysaccharides are functionalized using a source of free radicals which forms stable radicals on the polysaccharides structure and wherein the formed radicals reacts with a functionalized unsaturated compound. The method comprises two steps: a first step, wherein the free radical on the polysaccharides chain is formed, and a second step, wherein said radical reacts with the unsaturated compound in the absence of the radical source.
摘要翻译： 多糖使用自由基源进行功能化，自由基源在多糖结构上形成稳定的基团，其中形成的基团与官能化的不饱和化合物反应。 该方法包括两个步骤：第一步，其中形成多糖链上的自由基，第二步，其中所述自由基在不存在自由基源的情况下与不饱和化合物反应。
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4.发明申请公开(公告)号：US20060237302A1
公开(公告)日：2006-10-26
申请号：US10555897
申请日：2004-05-06
申请人： Luigi De Ambrosi , Donata Bensi , Elena Vismara
发明人： Luigi De Ambrosi , Donata Bensi , Elena Vismara
CPC分类号： C08B37/0063 , C08B37/0069 , C08B37/0078
摘要： The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of UVC radiation. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by Gel Permeation for obtaining the desired Molecular Weight.
摘要翻译： 本发明涉及以使用UVC辐射为特征的糖胺聚糖解聚方法。 本发明还涉及通过该方法得到的中间解聚肝素。 中间解聚的肝素可以溶解在缓冲溶液中，并通过凝胶渗透法分级，以获得所需的分子量。
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公开(公告)号：US08853387B2
公开(公告)日：2014-10-07
申请号：US13056085
申请日：2009-07-09
摘要： The present invention is directed to sulfated oligosaccharides having 4, 5 or 6 saccharidic units and wherein a glycosidic bond between two saccharide units is substituted by a C—C bond, and wherein the sulfation degree expressed as percentage of OH groups substituted by a OSO3− group is comprised between 50 and 100%. The sulfated oligosaccharides according to the invention are useful as a drug, in particular in the treatment of angiogenesis, metastasis, and inflammation.
摘要翻译： 本发明涉及具有4,5或6个糖苷单元的硫酸化低聚糖，并且其中两个糖单元之间的糖苷键被C-C键取代，并且其中所述硫酸化度表示为被OSO 3 - 组为50〜100％。 根据本发明的硫酸化寡糖可用作药物，特别是用于治疗血管生成，转移和炎症。
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6.发明授权公开(公告)号：US07321034B2
公开(公告)日：2008-01-22
申请号：US10518980
申请日：2003-06-18
申请人： Luigi De Ambrosi , Nicola Iannaccone , Sergio Gonella , Elena Vismara , Solitario Nesti , Giangiaocomo Torri
发明人： Luigi De Ambrosi , Nicola Iannaccone , Sergio Gonella , Elena Vismara , Solitario Nesti , Giangiaocomo Torri
IPC分类号： C08B37/10
CPC分类号： C08B37/0063 , C08B37/0075 , C08B37/0078
摘要： The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.
摘要翻译： 本发明涉及通过使用电子束辐射特征的糖胺聚糖解聚方法，任选地在选自醚，醇，醛，酰胺和甲酸的有机化合物存在下进行。 本发明还涉及通过该方法得到的中间解聚肝素。 中间解聚的肝素可以溶解在缓冲溶液中并通过凝胶渗透分馏以获得所需的分子量。
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7.发明授权公开(公告)号：US07605242B2
公开(公告)日：2009-10-20
申请号：US10555897
申请日：2004-05-06
申请人： Luigi De Ambrosi , Donata Bensi , Elena Vismara
发明人： Luigi De Ambrosi , Donata Bensi , Elena Vismara
CPC分类号： C08B37/0063 , C08B37/0069 , C08B37/0078
摘要： The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of UVC radiation. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.
摘要翻译： 本发明涉及以使用UVC辐射为特征的糖胺聚糖解聚方法。 本发明还涉及通过该方法得到的中间解聚肝素。 中间解聚的肝素可以溶解在缓冲溶液中并通过凝胶渗透分馏以获得所需的分子量。
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公开(公告)号：US20050108832A1
公开(公告)日：2005-05-26
申请号：US10506619
申请日：2003-03-20
申请人： Giangiacomo Torri , Elena Vismara , Alberti Angelo , Bertini Sabrina , Ciardelli Gianluca , Gastaldi Giuseppe , Nesti Solitario
发明人： Giangiacomo Torri , Elena Vismara , Alberti Angelo , Bertini Sabrina , Ciardelli Gianluca , Gastaldi Giuseppe , Nesti Solitario
摘要： The invention concerns a method for functionalizing polysaccharides using a source or free radicals which forms stable radicals on the polysaccharides structure and wherein the formed radicals reacts with a functionalized unsaturated compound, characterized in that the method comprises two steps: a first step, wherein the free radical on the polysaccharide chain is formed, and a second step, wherein said radical reacts with the unsaturated compound in the absence of the radical source. The invention also relates to the functionalized polysaccharide obtained by this process.
摘要翻译： 本发明涉及使用在多糖结构上形成稳定自由基的源或自由基官能化多糖的方法，其中形成的基团与官能化的不饱和化合物反应，其特征在于该方法包括两个步骤：第一步，其中游离 形成多糖链上的自由基，第二步，其中所述自由基在不存在自由基源的情况下与不饱和化合物反应。 本发明还涉及通过该方法获得的官能化多糖。
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公开(公告)号：US20120232263A1
公开(公告)日：2012-09-13
申请号：US13056085
申请日：2009-07-09
IPC分类号： C07H5/10
摘要： The present invention is directed to sulfated oligosaccharides having 4, 5 or 6 saccharidic units and wherein a glycosidic bond between two saccharide units is substituted by a C—C bond, and wherein the sulfation degree expressed as percentage of OH groups substituted by a OSO3− group is comprised between 50 and 100%. The sulfated oligosaccharides according to the invention are useful as a drug, in particular in the treatment of angiogenesis, metastasis, and inflammation.
摘要翻译： 本发明涉及具有4,5或6个糖苷单元的硫酸化低聚糖，并且其中两个糖单元之间的糖苷键被C-C键取代，并且其中所述硫酸化度表示为被OSO 3 - 组为50〜100％。 根据本发明的硫酸化寡糖可用作药物，特别是用于治疗血管生成，转移和炎症。
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10.发明申请MULTISTEP PROCESS FOR THE PHYSICAL DEPOLYMERIZATION OF HEPARIN AND PRODUCTS OBTAINED THEREFROM 有权HEPARIN及其获得的产品的物理多元化的多重方法公开(公告)号：US20070082869A1
公开(公告)日：2007-04-12
申请号：US11279699
申请日：2006-04-13
申请人： Luigi De Ambrosi , Sergio Gonella , Donata Bensi , Giangiacomo Torri , Antonella Bisio , Elena Vismara
发明人： Luigi De Ambrosi , Sergio Gonella , Donata Bensi , Giangiacomo Torri , Antonella Bisio , Elena Vismara
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： C08B37/0078
摘要： The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two γ-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.
摘要翻译： 本发明涉及用于肝素物理解聚的多步法，其中肝素经受至少两次伽马射线照射，并且其中在两个照射步骤之间进行解聚的肝素进行分离步骤，并且仅将解聚的肝素的一部分 从第一次照射得到的第二照射工序。 还涉及通过本发明的方法获得的肝素衍生的寡糖级分。
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