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1.发明授权Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives 失效包含自动交联透明质酸衍生物的无纺布材料
公开(公告)号：US5824335A
公开(公告)日：1998-10-20
申请号：US487407
申请日：1995-06-07
IPC分类号： D04H1/42 , D04H1/46 , D04H1/64 , D04H3/10 , D04H3/12 , A61K31/00 , A61L15/28 , B32B27/02 , B32B27/04
CPC分类号： D04H1/46 , D04H1/4266 , D04H1/64 , D04H3/105 , D04H3/12 , Y10T428/249922 , Y10T428/249934 , Y10T428/24994 , Y10T428/249942 , Y10T428/249947 , Y10T428/249953 , Y10T428/249955 , Y10T428/249962 , Y10T428/249964
摘要： Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable non-woven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials constitute threads embedded in a matrix, wherein both the matrix and the threads constitute auto-crosslinked hyaluronic acid.
摘要翻译： 公开的生物材料包括用于组织引导再生的手术中的可生物降解的，生物相容的和生物可吸收的无纺织物材料。 无纺布材料构成嵌入基质中的线，其中基质和线都构成自动交联的透明质酸。
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公开(公告)号：US06533820B2
公开(公告)日：2003-03-18
申请号：US09335900
申请日：1999-06-18
IPC分类号： A61F228
CPC分类号： A61L27/446 , A61L24/08 , A61L27/46 , A61L2430/02 , A61L24/0015 , A61F2/28 , A61F2/00 , C08L5/08 , A61L27/54
摘要： The present invention involves compositions for use as granular bone replacements. The compositions of the present invention are comprised of hyaluronic acid esters or salts of hyaluronic acid in association with a pharmacologically active compound wherein the molecular weight of the hyaluronic acid is below 250,000 and either artificial or natural bone granules. The present invention further involves a method of promoting the growth or repair of damaged or defective bones in either humans or animals using the compositions of hyaluronic acid derivatives and bone granules.
摘要翻译： 本发明涉及用作粒状骨替代物的组合物。 本发明的组合物由透明质酸酯或透明质酸的盐与透明质酸的分子量低于25万的药物活性化合物和人造或天然骨颗粒组成。 本发明还涉及使用透明质酸衍生物和骨颗粒的组合物促进人或动物中损伤或有缺陷的骨骼的生长或修复的方法。
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3.发明授权Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids 失效包含透明质酸的酯的可生物降解的导流通道用于组织修复，作为手术辅助剂
公开(公告)号：US5879359A
公开(公告)日：1999-03-09
申请号：US855285
申请日：1997-05-13
CPC分类号： A61L31/16 , A61F2/02 , A61L31/047 , A61L31/129 , A61L2300/412 , A61L2300/414 , A61L2430/32
摘要： The present invention is drawn to medical devices comprising biodegradable guide channels for use in the repair and regeneration of nerve tissue. The guide channels of the present invention comprise interlaced threads imbedded in a matrix, wherein both the matrix and the threads comprise biocompatible and bioabsorbable esters of hyaluronic acid. The matrix of the present invention further optionally comprises biologically or pharmacologically active factors in association with the guide channels.
摘要翻译： 本发明涉及包括用于神经组织的修复和再生的可生物降解的引导通道的医疗装置。 本发明的引导通道包括嵌入基质中的交织线，其中基质和线均包含透明质酸的生物相容性和生物可吸收的酯。 本发明的基质还任选地包括与引导通道相关联的生物学或药理学活性因子。
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4.发明授权Multilayer nonwoven tissue containing a surface layer comprising at least one hyaluronic acid ester 失效含有包含至少一种透明质酸酯的表层的多层非织造织物
公开(公告)号：US5658582A
公开(公告)日：1997-08-19
申请号：US505325
申请日：1995-10-10
IPC分类号： A61F13/00 , A61L15/00 , A61L15/28 , D06M16/00 , A01N25/34 , A61L15/16 , B32B5/22 , B32B17/02
CPC分类号： D06M16/00 , A61F13/00012 , A61F13/00017 , A61F13/00063 , A61L15/28 , A61F2013/00097 , A61F2013/00229 , A61F2013/00263 , A61F2013/00476 , A61F2013/00523 , A61F2013/00744 , A61F2013/00876 , A61F2013/0091 , A61F2013/00927 , A61F2013/00931 , Y10T428/24124
摘要： Provided is a multilayered of nonwoven material comprising a surface layer which comes into contact with the skin, and one or more other layers which do not come into contact with the skin, wherein said surface layer which comes into contact with the skin is a member selected from the group consisting of a surface layer comprising at least one hyaluronic acid ester, a surface layer comprising a mixture of said at least one hyaluronic acid ester and at least one natural polymer, semisynthetic polymer, or synthetic polymer, and a surface layer comprising a natural, synthetic, or semisynthetic biocompatible perforated membrane compatible with cell growth on its surface. This material can be employed in a wide variety of medical and sanitary applications, including surgery and as a non-adhesive covering material.
摘要翻译： PCT No.PCT / EP94 / 00397 Sec。 371 1995年10月10日第 102（e）日期1995年10月10日PCT 1994年2月11日提交PCT公布。 公开号WO94 / 17837 日期1994年8月18日提出了一种多层非织造材料，其包括与皮肤接触的表面层和不与皮肤接触的一个或多个其它层，其中与 皮肤是选自包含至少一种透明质酸酯的表面层，包含所述至少一种透明质酸酯和至少一种天然聚合物，半合成聚合物或合成聚合物的混合物的表面层，以及 表面层包含与其表面上的细胞生长相容的天然的，合成的或半合成的生物相容性穿孔膜。 该材料可用于各种医疗和卫生应用，包括手术和非粘性覆盖材料。
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公开(公告)号：US5622707A
公开(公告)日：1997-04-22
申请号：US992697
申请日：1992-12-18
IPC分类号： A61L15/22 , A61F2/10 , A61L15/07 , A61L27/48 , A61L31/00 , A61L31/04 , A61L31/12 , A61L31/14 , D01F9/00 , D01F9/04 , D03D15/00 , D04H1/42 , D04H13/00 , D06M15/03 , A61K9/70 , A61K31/00
CPC分类号： A61L31/148 , A61F2/105 , A61L27/48 , A61L31/041 , A61L31/042 , A61L31/129 , Y10T428/24124 , Y10T442/172
摘要： Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable composite membranes for use in surgery for the guided regeneration of tissues. The composite membranes are comprised of threads embedded in a matrix, wherein both the matrix and the threads can be comprised of esters of hyaluronic acid, used singly or in combination, or esters of hyaluronic acid in combination with esters of alginic acid or other polymers.
摘要翻译： 公开的生物材料包括用于组织引导再生的手术中的可生物降解的，生物相容的和生物可吸收的复合膜。 复合膜由嵌入基质中的线组成，其中基质和丝线都可以由透明质酸单独或组合使用的酯，或透明质酸的酯与藻酸或其它聚合物的酯组合而成。
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公开(公告)号：US5520916A
公开(公告)日：1996-05-28
申请号：US992700
申请日：1992-12-18
IPC分类号： A61L15/07 , A61L15/22 , A61L15/28 , A61L15/64 , A61L31/00 , D04H1/42 , D04H1/4266 , D04H1/435 , D04H1/46 , D04H1/74 , D04H3/12 , A61K9/70
CPC分类号： D04H1/74 , A61L15/225 , A61L15/28 , D01D5/06 , D01F9/00 , D04H1/4266 , D04H1/435 , D04H1/4382 , D04H1/46 , D04H3/12 , Y10T428/24124 , Y10T442/686 , Y10T442/692
摘要： Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable nonwoven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials are comprised of threads embedded in a matrix, wherein both the matrix and the threads can be comprised of esters of hyaluronic acid, used singly or in combination, or esters of hyaluronic acid in combination with esters of alginic acid or other polymers.
摘要翻译： 公开的生物材料包括用于组织引导再生的手术中的可生物降解的，生物相容的和生物可吸收的无纺布材料。 无纺布材料由嵌入基质中的线组成，其中基质和线可以由透明质酸的酯单独或组合使用，或透明质酸的酯与海藻酸的酯或 其他聚合物。
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7.发明授权Biomaterials, their preparation by electrospinning and their use in the biomedical and surgical field 有权生物材料，它们通过静电纺丝制备及其在生物医学和外科领域的应用公开(公告)号：US08865964B2
公开(公告)日：2014-10-21
申请号：US13056541
申请日：2009-07-24
CPC分类号： A61L27/60 , Y10T442/3065 , Y10T442/614 , Y10T442/626
摘要： There is described a new non-woven fabric produced with the electrospinning technique, and the use thereof as new biomaterial for the biomedical and surgical field.
摘要翻译： 描述了一种用静电纺丝技术生产的新型无纺织物，并将其用作生物医学和外科领域的新生物材料。
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8.发明授权公开(公告)号：US08147811B1
公开(公告)日：2012-04-03
申请号：US10019387
申请日：2000-06-29
IPC分类号： A61K8/18
CPC分类号： A61K31/728 , A61K31/715 , A61L15/28 , A61L15/44 , A61L17/005 , A61L17/10 , A61L31/042 , A61L31/16 , A61L2300/00 , A61L2300/236 , A61L2300/404 , A61L2300/414 , A61L2300/45 , A61K31/00 , A61K2300/00 , C08L5/08
摘要： Use of hyaluronic acid derivatives for the preparation of biomaterials for the prevention of the formation and the treatment of cutaneous scars, wherein the hyaluronic acid derivatives are optionally combined with pharmacologically or biologically active compounds.
摘要翻译： 透明质酸衍生物用于制备用于预防皮肤瘢痕形成和治疗的生物材料的透明质酸衍生物，其中任选地与药理学或生物活性化合物组合。
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9.发明授权Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy 有权使用含有透明质酸衍生物的立体支架的生物材料用于在关节镜中制备植入物，以及用于通过关节镜检查植入所述生物材料的器械的试剂盒公开(公告)号：US07722616B2
公开(公告)日：2010-05-25
申请号：US10250408
申请日：2001-12-27
CPC分类号： A61L27/3804 , A61L27/20 , A61L27/3852 , C08L5/08
摘要： The invention relates to use of a biological material containing cells supported on three-dimensional scaffolds containing at least one hyaluronic acid derivative for the preparation of grafts suitable for application by arthroscopy, and a kit of surgical instruments for implanting said biological material by arthroscopy.
摘要翻译： 本发明涉及包含支持在含有至少一种透明质酸衍生物的三维支架上的细胞的生物材料用于制备适于通过关节镜检查应用的移植物的用途，以及用于通过关节镜检查植入所述生物材料的外科器械套件的用途。
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10.发明授权Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins 失效用于输送成骨蛋白质的透明质酸衍生物的可注射载体制剂公开(公告)号：US07608580B2
公开(公告)日：2009-10-27
申请号：US11624463
申请日：2007-01-18
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/16
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
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