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1.发明授权Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives 失效包含自动交联透明质酸衍生物的无纺布材料
公开(公告)号：US5824335A
公开(公告)日：1998-10-20
申请号：US487407
申请日：1995-06-07
IPC分类号： D04H1/42 , D04H1/46 , D04H1/64 , D04H3/10 , D04H3/12 , A61K31/00 , A61L15/28 , B32B27/02 , B32B27/04
CPC分类号： D04H1/46 , D04H1/4266 , D04H1/64 , D04H3/105 , D04H3/12 , Y10T428/249922 , Y10T428/249934 , Y10T428/24994 , Y10T428/249942 , Y10T428/249947 , Y10T428/249953 , Y10T428/249955 , Y10T428/249962 , Y10T428/249964
摘要： Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable non-woven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials constitute threads embedded in a matrix, wherein both the matrix and the threads constitute auto-crosslinked hyaluronic acid.
摘要翻译： 公开的生物材料包括用于组织引导再生的手术中的可生物降解的，生物相容的和生物可吸收的无纺织物材料。 无纺布材料构成嵌入基质中的线，其中基质和线都构成自动交联的透明质酸。
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公开(公告)号：US06533820B2
公开(公告)日：2003-03-18
申请号：US09335900
申请日：1999-06-18
IPC分类号： A61F228
CPC分类号： A61L27/446 , A61L24/08 , A61L27/46 , A61L2430/02 , A61L24/0015 , A61F2/28 , A61F2/00 , C08L5/08 , A61L27/54
摘要： The present invention involves compositions for use as granular bone replacements. The compositions of the present invention are comprised of hyaluronic acid esters or salts of hyaluronic acid in association with a pharmacologically active compound wherein the molecular weight of the hyaluronic acid is below 250,000 and either artificial or natural bone granules. The present invention further involves a method of promoting the growth or repair of damaged or defective bones in either humans or animals using the compositions of hyaluronic acid derivatives and bone granules.
摘要翻译： 本发明涉及用作粒状骨替代物的组合物。 本发明的组合物由透明质酸酯或透明质酸的盐与透明质酸的分子量低于25万的药物活性化合物和人造或天然骨颗粒组成。 本发明还涉及使用透明质酸衍生物和骨颗粒的组合物促进人或动物中损伤或有缺陷的骨骼的生长或修复的方法。
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3.发明授权Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids 失效包含透明质酸的酯的可生物降解的导流通道用于组织修复，作为手术辅助剂
公开(公告)号：US5879359A
公开(公告)日：1999-03-09
申请号：US855285
申请日：1997-05-13
CPC分类号： A61L31/16 , A61F2/02 , A61L31/047 , A61L31/129 , A61L2300/412 , A61L2300/414 , A61L2430/32
摘要： The present invention is drawn to medical devices comprising biodegradable guide channels for use in the repair and regeneration of nerve tissue. The guide channels of the present invention comprise interlaced threads imbedded in a matrix, wherein both the matrix and the threads comprise biocompatible and bioabsorbable esters of hyaluronic acid. The matrix of the present invention further optionally comprises biologically or pharmacologically active factors in association with the guide channels.
摘要翻译： 本发明涉及包括用于神经组织的修复和再生的可生物降解的引导通道的医疗装置。 本发明的引导通道包括嵌入基质中的交织线，其中基质和线均包含透明质酸的生物相容性和生物可吸收的酯。 本发明的基质还任选地包括与引导通道相关联的生物学或药理学活性因子。
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公开(公告)号：US5622707A
公开(公告)日：1997-04-22
申请号：US992697
申请日：1992-12-18
IPC分类号： A61L15/22 , A61F2/10 , A61L15/07 , A61L27/48 , A61L31/00 , A61L31/04 , A61L31/12 , A61L31/14 , D01F9/00 , D01F9/04 , D03D15/00 , D04H1/42 , D04H13/00 , D06M15/03 , A61K9/70 , A61K31/00
CPC分类号： A61L31/148 , A61F2/105 , A61L27/48 , A61L31/041 , A61L31/042 , A61L31/129 , Y10T428/24124 , Y10T442/172
摘要： Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable composite membranes for use in surgery for the guided regeneration of tissues. The composite membranes are comprised of threads embedded in a matrix, wherein both the matrix and the threads can be comprised of esters of hyaluronic acid, used singly or in combination, or esters of hyaluronic acid in combination with esters of alginic acid or other polymers.
摘要翻译： 公开的生物材料包括用于组织引导再生的手术中的可生物降解的，生物相容的和生物可吸收的复合膜。 复合膜由嵌入基质中的线组成，其中基质和丝线都可以由透明质酸单独或组合使用的酯，或透明质酸的酯与藻酸或其它聚合物的酯组合而成。
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公开(公告)号：US5520916A
公开(公告)日：1996-05-28
申请号：US992700
申请日：1992-12-18
IPC分类号： A61L15/07 , A61L15/22 , A61L15/28 , A61L15/64 , A61L31/00 , D04H1/42 , D04H1/4266 , D04H1/435 , D04H1/46 , D04H1/74 , D04H3/12 , A61K9/70
CPC分类号： D04H1/74 , A61L15/225 , A61L15/28 , D01D5/06 , D01F9/00 , D04H1/4266 , D04H1/435 , D04H1/4382 , D04H1/46 , D04H3/12 , Y10T428/24124 , Y10T442/686 , Y10T442/692
摘要： Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable nonwoven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials are comprised of threads embedded in a matrix, wherein both the matrix and the threads can be comprised of esters of hyaluronic acid, used singly or in combination, or esters of hyaluronic acid in combination with esters of alginic acid or other polymers.
摘要翻译： 公开的生物材料包括用于组织引导再生的手术中的可生物降解的，生物相容的和生物可吸收的无纺布材料。 无纺布材料由嵌入基质中的线组成，其中基质和线可以由透明质酸的酯单独或组合使用，或透明质酸的酯与海藻酸的酯或 其他聚合物。
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6.发明授权Multilayer nonwoven tissue containing a surface layer comprising at least one hyaluronic acid ester 失效含有包含至少一种透明质酸酯的表层的多层非织造织物
公开(公告)号：US5658582A
公开(公告)日：1997-08-19
申请号：US505325
申请日：1995-10-10
IPC分类号： A61F13/00 , A61L15/00 , A61L15/28 , D06M16/00 , A01N25/34 , A61L15/16 , B32B5/22 , B32B17/02
CPC分类号： D06M16/00 , A61F13/00012 , A61F13/00017 , A61F13/00063 , A61L15/28 , A61F2013/00097 , A61F2013/00229 , A61F2013/00263 , A61F2013/00476 , A61F2013/00523 , A61F2013/00744 , A61F2013/00876 , A61F2013/0091 , A61F2013/00927 , A61F2013/00931 , Y10T428/24124
摘要： Provided is a multilayered of nonwoven material comprising a surface layer which comes into contact with the skin, and one or more other layers which do not come into contact with the skin, wherein said surface layer which comes into contact with the skin is a member selected from the group consisting of a surface layer comprising at least one hyaluronic acid ester, a surface layer comprising a mixture of said at least one hyaluronic acid ester and at least one natural polymer, semisynthetic polymer, or synthetic polymer, and a surface layer comprising a natural, synthetic, or semisynthetic biocompatible perforated membrane compatible with cell growth on its surface. This material can be employed in a wide variety of medical and sanitary applications, including surgery and as a non-adhesive covering material.
摘要翻译： PCT No.PCT / EP94 / 00397 Sec。 371 1995年10月10日第 102（e）日期1995年10月10日PCT 1994年2月11日提交PCT公布。 公开号WO94 / 17837 日期1994年8月18日提出了一种多层非织造材料，其包括与皮肤接触的表面层和不与皮肤接触的一个或多个其它层，其中与 皮肤是选自包含至少一种透明质酸酯的表面层，包含所述至少一种透明质酸酯和至少一种天然聚合物，半合成聚合物或合成聚合物的混合物的表面层，以及 表面层包含与其表面上的细胞生长相容的天然的，合成的或半合成的生物相容性穿孔膜。 该材料可用于各种医疗和卫生应用，包括手术和非粘性覆盖材料。
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公开(公告)号：US5300493A
公开(公告)日：1994-04-05
申请号：US945495
申请日：1992-09-16
申请人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
发明人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
IPC分类号： A61K20060101 , A61K31/045 , A61K31/715 , A61K31/73
CPC分类号： A61K31/045 , A61K31/715 , Y10S514/925 , Y10S514/926
摘要： Acidic polysaccharide esters containing carboxylic groups are useful for protecting against and curing ulcers of the gastro-enteric system. These esters include choline esters with acidic polysaccharide selected from the group consisting of hyaluronic acid, alginic acid, gellan, oxidized cellulose, oxidized chitin, carboxy-hydrocarbyl-cellulose, carboxy-hydrocarbyl-starch and carboxy-hydrocarbyl-chitin, wherein the term hydrocarbyl means the residue of a hydrocarbon selected from the group consisting of by alkyl, aralkyl and cycloalkyl.
摘要翻译： 含有羧基的酸性多糖酯可用于防止和治疗胃肠系统的溃疡。 这些酯包括选自透明质酸，海藻酸，结冷胶，氧化纤维素，氧化几丁质，羧基 - 烃基 - 纤维素，羧基 - 烃基 - 淀粉和羧基 - 烃基几丁质的酸性多糖的胆碱酯，其中术语烃基 是指选自烷基，芳烷基和环烷基的烃的残基。
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8.发明授权
公开(公告)号：US6066340A
公开(公告)日：2000-05-23
申请号：US169558
申请日：1993-12-20
IPC分类号： A61K9/50 , A61K9/00 , A61K9/16 , A61K9/52 , A61K31/715 , A61K38/18 , A61K38/22 , A61K38/23 , A61K38/28 , A61K39/395 , A61K47/36
CPC分类号： A61K38/28 , A61K38/185 , A61K38/23 , A61K9/0034 , A61K9/1652 , Y10S514/866 , Y10S514/951 , Y10S514/963
摘要： The present invention is directed to a microsphere for the controlled release of a biologically active molecule which comprises a biologically active molecule and an ester of hyaluronic acid or mixtures of said esters of hyaluronic acids, and wherein said biologically active molecule is surrounded by or adhered to said ester of hyaluronic acid, and wherein said microsphere has a diameter of between 1 .mu.m to 100 .mu.m.
摘要翻译： 本发明涉及用于受控释放生物活性分子的微球，其包含生物活性分子和透明质酸的酯或所述透明质酸酯的混合物，并且其中所述生物活性分子包围或粘附于 所述透明质酸酯，其中所述微球的直径在1μm至100μm之间。
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公开(公告)号：US6039970A
公开(公告)日：2000-03-21
申请号：US231353
申请日：1999-01-13
IPC分类号： A61K9/50 , A61K9/00 , A61K9/16 , A61K9/52 , A61K31/715 , A61K38/18 , A61K38/22 , A61K38/23 , A61K38/28 , A61K39/395 , A61K47/36
CPC分类号： A61K38/28 , A61K38/185 , A61K38/23 , A61K9/0034 , A61K9/1652 , Y10S514/866 , Y10S514/951 , Y10S514/963
摘要： The present invention is directed to a microsphere for the controlled release of a biologically active molecule which comprises a biologically active molecule and an ester of hyaluronic acid or mixtures of said esters of hyaluronic acids, and wherein said biologically active molecule is surrounded by or adhered to said ester of hyaluronic acid, and wherein said microsphere has a diameter of between 1 .mu.m to 100 .mu.m.
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公开(公告)号：US5538730A
公开(公告)日：1996-07-23
申请号：US216858
申请日：1994-03-24
申请人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
发明人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
IPC分类号： A61K8/72 , A61K8/00 , A61K8/73 , A61L15/28 , A61L27/00 , A61L27/20 , A61Q19/00 , C08B37/08 , A61K47/38 , A61K9/00
CPC分类号： A61K8/736 , A61L15/28 , A61L27/20 , A61Q19/00 , C08B37/003
摘要： Copolymers of the formula: ##STR1## wherein the bonds between the glucoside units are .beta. (1.fwdarw.4), the degree of polymerization referred to a single glucoside unit varies from about 50 to 50,000, R is a free or esterified carboxy group and S is an amino or acylamino group. The part designated by x may vary between about 5% and 100% and that designated by y may vary between about 95% and 0%. At least a part of the R groups are esterified carboxy groups, and at least a part of the S groups are acylamino groups. Salts of these copolymers are also disclosed. The products of the invention are particularly useful in the cosmetic field.
摘要翻译： 下式的共聚物：其中葡萄糖苷单元之间的键是β（1-> 4），所指的单糖苷单元的聚合度在约50至50,000之间变化，R是游离或酯化的羧基， S是氨基或酰氨基。 由x指定的部分可以在约5％和100％之间变化，并且由y指定的部分可以在约95％和0％之间变化。 R基团的至少一部分是酯化的羧基，并且至少一部分S基团是酰基氨基。 还公开了这些共聚物的盐。 本发明的产品在化妆品领域特别有用。
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