公开(公告)号：US20070283675A1

公开(公告)日：2007-12-13

申请号：US11744031

申请日：2007-05-03

申请人： Frank Hancock ,  Stephen Price

发明人： Frank Hancock ,  Stephen Price

IPC分类号： A01D34/00

CPC分类号： A01D34/006 ,  A01D34/828

摘要： One or more elongate barriers are provided that are movably (in one configuration pivotably) mounted proximate the outside of a grass cutting deck. When one of the barriers encounters a foreign object in a certain manner, the barrier moves towards its “tripped” position, thus causing a corresponding change to the operating characteristic of the lawn mover, be it a termination of the cutting process, the mower drive process, or both. The barriers can be used with electric or mechanical control elements.

摘要翻译： 提供了一个或多个细长的屏障，其可移动地（在一个结构中可枢转地）安装在靠近切割甲板的外部。 当其中一个障碍物以某种方式遇到异物时，障碍物朝向其“跳闸”位置移动，从而相应地改变了草坪移动器的操作特性，无论是切割过程的终止，割草机驱动 过程或两者。 障碍物可用于电动或机械控制元件。

公开(公告)号：US20050193707A1

公开(公告)日：2005-09-08

申请号：US11048618

申请日：2005-02-01

申请人： Frank Hancock ,  Stephen Price

发明人： Frank Hancock ,  Stephen Price

IPC分类号： A01D34/73 ,  A01D34/52

CPC分类号： A01D34/73

摘要： A grass cutting blade is provided which can be rotated in either direction while providing cutting and airlift in either direction. This can be used in cooperation with a cutting deck housing which includes a particular discharge opening and channel configuration which facilitates side discharge for one blade direction and mulching in the other. By controlling the blade direction, such as by an electric switch controlling electric blade shaft drive motor, side discharge or mulching can be had at a flip of a switch.

公开(公告)号：US20050081500A1

公开(公告)日：2005-04-21

申请号：US10924758

申请日：2004-08-24

申请人： Frank Hancock ,  Stephen Price

发明人： Frank Hancock ,  Stephen Price

IPC分类号： A01D34/86 ,  A01D34/52

CPC分类号： A01D34/863 ,  A01D34/828 ,  A01D2101/00

摘要： One or more elongate barriers are provided that are movably (in one configuration pivotably) mounted proximate the outside of a grass cutting deck. When one of the barriers encounters a foreign object in a certain manner, the barrier moves towards its “tripped” position, thus causing a corresponding change to the operating characteristic of the lawn mover, be it a termination of the cutting process, the mower drive process, or both. The barriers can be used with electric or mechanical control elements.

摘要翻译： 提供了一个或多个细长的屏障，其可移动地（在一个结构中可枢转地）安装在靠近切割甲板的外部。 当其中一个障碍物以某种方式遇到异物时，障碍物朝向其“跳闸”位置移动，从而相应地改变了草坪移动器的操作特性，无论是切割过程的终止，割草机驱动 过程或两者。 障碍物可用于电动或机械控制元件。

公开(公告)号：US08852937B2

公开(公告)日：2014-10-07

申请号：US11894557

申请日：2007-08-20

申请人： Anthony David Baxter ,  Edward Andrew Boyd ,  Maria Frank-Kamenetsky ,  Oivin Guicherit ,  Jeffery Porter ,  Stephen Price ,  Lee Rubin ,  John Harry Alexander Stibbard

发明人： Anthony David Baxter ,  Edward Andrew Boyd ,  Maria Frank-Kamenetsky ,  Oivin Guicherit ,  Jeffery Porter ,  Stephen Price ,  Lee Rubin ,  John Harry Alexander Stibbard

IPC分类号： C12N5/00 ,  A01N43/12 ,  A01N43/06 ,  A01N43/64 ,  C07D409/14 ,  C07D333/70 ,  A61K31/4436 ,  A61K31/44 ,  A61K31/517 ,  A61K31/50 ,  A61K31/422 ,  A61K31/381 ,  C07D409/12

CPC分类号： A61K31/381 ,  A61K31/422 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/50 ,  A61K31/517 ,  C07D333/70 ,  C07D409/12 ,  C07D409/14

摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

摘要翻译： 本发明提供用于调节细胞或组织中的增殖或分化的可用方法和试剂，包括使细胞与刺猬激动剂接触，所述刺猬激动剂例如图1和图2所示的化合物。 在某些实施方案中，可以使用方法和试剂来校正或抑制异常或不想要的生长状态，例如通过拮抗正常的ptc途径或激动平滑的或刺猬活性。

公开(公告)号：US08841462B2

公开(公告)日：2014-09-23

申请号：US12999003

申请日：2009-07-01

申请人： Robert A. Heald ,  Philip Jackson ,  Joseph P. Lyssikatos ,  Stephen Price ,  Pascal Pierre Alexandre Savy

发明人： Robert A. Heald ,  Philip Jackson ,  Joseph P. Lyssikatos ,  Stephen Price ,  Pascal Pierre Alexandre Savy

IPC分类号： C07D275/04 ,  C07D231/56 ,  C07D513/04 ,  C07D471/04 ,  A61K31/437 ,  A61K31/428 ,  A61K31/416

CPC分类号： C07D231/56 ,  C07D275/04 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

摘要： The invention relates to bicyclic heterocycles of formulae I and II with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

摘要翻译： 本发明涉及式I和II的双环杂环，其具有抗癌和/或抗炎活性，更具体地涉及MEK激酶抑制活性。 本发明提供了可用于抑制异常细胞生长，治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

公开(公告)号：US20120244149A1

公开(公告)日：2012-09-27

申请号：US13477587

申请日：2012-05-22

申请人： Nicole Blaquiere ,  Steven Do ,  Danette Dudley ,  Adrian Folkes ,  Robert Heald ,  Timothy Heffron ,  Mark Jones ,  Aleksandr Kolesnikov ,  Chudi Ndubaku ,  Alan G. Olivero ,  Stephen Price ,  Steven Staben ,  Lan Wang

发明人： Nicole Blaquiere ,  Steven Do ,  Danette Dudley ,  Adrian Folkes ,  Robert Heald ,  Timothy Heffron ,  Mark Jones ,  Aleksandr Kolesnikov ,  Chudi Ndubaku ,  Alan G. Olivero ,  Stephen Price ,  Steven Staben ,  Lan Wang

IPC分类号： A61K31/553 ,  A61K31/565 ,  A61P35/00 ,  A61P29/00 ,  A61P37/02 ,  A61P37/04 ,  A61P9/00 ,  A61P31/12 ,  A61P7/00 ,  A61P3/10 ,  A61P1/16 ,  A61K39/395 ,  A61P25/00

CPC分类号： C07D498/04 ,  A61K31/553 ,  A61K45/06 ,  C07D491/044 ,  C07D498/14 ,  C07D519/00

摘要： Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

摘要翻译： 式I的苯并氧氮杂化合物，包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物及其药学上可接受的盐，其中：Z1是CR1或N; Z2为CR2或N; Z3为CR3或N; Z4是CR4或N; B是与苯并氧杂环环稠合的吡唑基，咪唑基或三唑基环，可用于抑制脂质激酶，包括p110α和PI3K的其他同种型，并用于治疗由脂质激酶介导的癌症等疾病。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US08263633B2

公开(公告)日：2012-09-11

申请号：US12890810

申请日：2010-09-27

申请人： Nicole Blaquiere ,  Steven Do ,  Danette Dudley ,  Adrian Folkes ,  Richard Goldsmith ,  Robert Heald ,  Timothy Heffron ,  Aleksandr Kolesnikov ,  Chudi Ndubaku ,  Alan G. Olivero ,  Stephen Price ,  Steven Staben ,  BinQing Wei

发明人： Nicole Blaquiere ,  Steven Do ,  Danette Dudley ,  Adrian Folkes ,  Richard Goldsmith ,  Robert Heald ,  Timothy Heffron ,  Aleksandr Kolesnikov ,  Chudi Ndubaku ,  Alan G. Olivero ,  Stephen Price ,  Steven Staben ,  BinQing Wei

IPC分类号： A61K31/41 ,  C07D249/14

CPC分类号： C07D495/04 ,  A61K31/381 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06 ,  C07D249/14 ,  C07D495/14 ,  C07D513/04 ,  C07D513/14

摘要： Benzoxepin compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and where (i) X1 is N and X2 is S, (ii) X1 is S and X2 is N, (iii) X1 is CR7 and X2 is S, (iv) X1 is S and X2 is CR7; (v) X1 is NR8 and X2 is N, (vi) X1 is N and X2 is NR8, (vii) X1 is CR7 and X2 is O, (viii) X1 is O and X2 is CR7, (ix) X1 is CR7 and X2 is C(R7)2, (x) X1 is C(R7)2 and X2 is CR7; (xi) X1 is N and X2 is O, or (xii) X1 is O and X2 is N, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

摘要翻译： 式I的苯并氧杂环己烯化合物，包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物及其药学上可接受的盐，其中：Z1是CR1或N; Z2为CR2或N; Z3为CR3或N; Z4是CR4或N; 并且其中（i）X1为N且X2为S，（ii）X1为S且X2为N，（iii）X1为CR7，X2为S，（iv）X1为S且X2为CR7; （ⅴ）X1为NR8，X2为N，（vi）X1为N，X2为NR8，i X1为CR7，X2为O，（ii）X1为O，X2为CR7，ix为CR7 X2为C（R7）2，（x）X1为C（R7）2，X2为CR7; （xi）X1是N，X2是O，或（xii）X1是O，X2是N，可用于抑制脂质激酶，包括p110α和PI3K的其他同种型，并用于治疗由脂质激酶介导的癌症等疾病。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US20100280063A1

公开(公告)日：2010-11-04

申请号：US12808346

申请日：2008-12-18

申请人： Stephen Price ,  Robert Heald ,  Pascal Pierre Alexandre Savy

发明人： Stephen Price ,  Robert Heald ,  Pascal Pierre Alexandre Savy

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The invention relates to imidazopyridines of formula I with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

摘要翻译： 本发明涉及式I的咪唑并吡啶与抗癌和/或抗炎活性，更具体地涉及抑制MEK激酶活性的咪唑并吡啶类。 本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

公开(公告)号：US07816369B2

公开(公告)日：2010-10-19

申请号：US11718470

申请日：2005-11-03

申请人： Oivin M. Guicherit ,  Edward Andrew Boyd ,  Judith Boyd, legal representative ,  Shirley Ann Brunton ,  Stephen Price ,  John Harry Alexander Stibbard ,  Colin H. MacKinnon

发明人： Oivin M. Guicherit ,  Edward Andrew Boyd ,  Shirley Ann Brunton ,  Stephen Price ,  John Harry Alexander Stibbard ,  Colin H. MacKinnon

IPC分类号： A61K31/4427 ,  C07D471/04 ,  C07D413/02 ,  C07D401/02

CPC分类号： A61K31/4427 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04

摘要： The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

摘要翻译： 本发明提供用于抑制由刺猬获得功能，功能丧失功能或平滑增益功能引起的异常生长状态的可用方法和试剂，包括使细胞与式（1）的刺猬蛋白拮抗剂接触， 足够量的异常生长状态，例如，激发正常的ptc途径或拮抗平滑或刺猬活性。

公开(公告)号：US20100016306A1

公开(公告)日：2010-01-21

申请号：US12298507

申请日：2007-04-25

申请人： Stewart James Baker ,  Paul John Goldsmith ,  Timothy Colin Hancox ,  Neil Anthony Pegg ,  Stephen Price ,  Stephen Joseph Shuttleworth ,  Sukhjit Sohal

发明人： Stewart James Baker ,  Paul John Goldsmith ,  Timothy Colin Hancox ,  Neil Anthony Pegg ,  Stephen Price ,  Stephen Joseph Shuttleworth ,  Sukhjit Sohal

IPC分类号： A61K31/5377 ,  C07D495/04 ,  A61P35/00

CPC分类号： C07D495/04

摘要： Thienopyrimidines of formula (Ia) or (Ib): wherein R1-R3 have any of the values described herein, and the pharmaceutically acceptable salt thereof have activity as inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase, in particular the p110 delta subtype, such as immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.

摘要翻译： 式（Ia）或（Ib）的噻吩并嘧啶：其中R1-R3具有本文所述的任何值，并且其药学上可接受的盐具有作为PI3K抑制剂的活性，因此可用于治疗由异常细胞生长引起的疾病和障碍 ，与PI3激酶，特别是p110δ亚型相关的功能或行为，例如免疫疾病，心血管疾病，病毒感染，炎症，代谢/内分泌障碍和神经障碍。 还描述了合成化合物的方法。