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46 条记录 (耗时 0.031 秒)

    Estrogen receptor modulators
    1.
    发明授权
    Estrogen receptor modulators 失效

    公开(公告)号：US06750213B2

    公开(公告)日：2004-06-15

    申请号：US10120723

    申请日：2002-04-11

    申请人： Frank P. DiNinno ,  Jane Y. Wu ,  Seongkon Kim ,  Helen Y. Chen

    发明人： Frank P. DiNinno ,  Jane Y. Wu ,  Seongkon Kim ,  Helen Y. Chen

    IPC分类号： A61K31395

    CPC分类号： C07D327/06 ,  C07D339/08 ,  C07D411/04

    摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

    Estrogen receptor modulators
    2.
    发明授权
    Estrogen receptor modulators 有权

    公开(公告)号：US07138426B2

    公开(公告)日：2006-11-21

    申请号：US10512172

    申请日：2003-04-18

    申请人： Frank P. DiNinno ,  Timothy Allen Blizzard ,  Jerry Dwain Morgan, II

    发明人： Frank P. DiNinno ,  Timothy Allen Blizzard ,  Jerry Dwain Morgan, II

    IPC分类号： A61K31/4025 ,  C07D411/12

    CPC分类号： C07D327/06

    摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

    6-Ethylpenicillanic acid
    8.
    发明授权
    6-Ethylpenicillanic acid 失效
    6-乙基青霉烷酸

    公开(公告)号：US4123539A

    公开(公告)日：1978-10-31

    申请号：US865639

    申请日：1977-12-29

    申请人： Frank P. DiNinno

    发明人： Frank P. DiNinno

    IPC分类号： A61K31/425 ,  C07D513/04

    CPC分类号： C07D499/88

    摘要： Disclosed are the antibiotics 6-ethylpenicillanic acid and 6-ethylpenicillanic acid sulfoxide (I): ##STR1## Also disclosed are processes for preparing I and its pharmaceutically acceptable salts and esters; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

    摘要翻译： 公开了抗生素6-乙基青霉烷酸和6-乙基青霉烷酸亚砜（I）：其中还公开了制备I及其药学上可接受的盐和酯的方法; 包含这些化合物的药物组合物; 和治疗方法，包括当指出抗生素效应时施用这些化合物和组合物。