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    CELL ASSAY KIT AND METHOD
    1.
    发明申请
    CELL ASSAY KIT AND METHOD 有权
    细胞测定试剂盒和方法

    公开(公告)号：US20110207150A1

    公开(公告)日：2011-08-25

    申请号：US12681601

    申请日：2008-12-05

    申请人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus-Munoz ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    发明人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus-Munoz ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    IPC分类号： G01N33/53 ,  G01N33/569 ,  C12M1/34

    CPC分类号： G01N33/54326 ,  G01N33/491 ,  G01N33/538 ,  G01N33/54313 ,  G01N33/56972

    摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

    摘要翻译： 公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。 该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够 特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。 在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域 收集室。 与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

    Cell assay kit and method
    2.
    发明授权
    Cell assay kit and method 有权
    细胞测定试剂盒和方法

    公开(公告)号：US08765391B2

    公开(公告)日：2014-07-01

    申请号：US12859973

    申请日：2010-08-20

    申请人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus-Munoz ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    发明人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus-Munoz ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    IPC分类号： G01N33/00 ,  G01N33/543 ,  G01N33/553 ,  G01N1/18

    CPC分类号： G01N33/54326 ,  G01N33/491 ,  G01N33/538 ,  G01N33/54313 ,  G01N33/56972

    摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

    摘要翻译： 公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。 该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够 特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。 在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域 收集室。 与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

    Cell assay kit and method
    3.
    发明授权
    Cell assay kit and method 有权
    细胞测定试剂盒和方法

    公开(公告)号：US08304203B2

    公开(公告)日：2012-11-06

    申请号：US12681601

    申请日：2008-12-05

    申请人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus-Munoz ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    发明人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus-Munoz ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    IPC分类号： G01N33/00 ,  G01N7/00 ,  G01N1/18 ,  F04B19/00 ,  B01L3/00

    CPC分类号： G01N33/54326 ,  G01N33/491 ,  G01N33/538 ,  G01N33/54313 ,  G01N33/56972

    摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

    摘要翻译： 公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。 该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够 特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。 在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域 收集室。 与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

    Cell assay kit and method
    4.
    发明授权
    Cell assay kit and method 有权
    细胞测定试剂盒和方法

    公开(公告)号：US07998696B2

    公开(公告)日：2011-08-16

    申请号：US12329380

    申请日：2008-12-05

    申请人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus-Munoz ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    发明人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus-Munoz ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    IPC分类号： G01N33/00 ,  G01N7/00 ,  G01N1/18 ,  F04B19/00 ,  B01L3/00

    CPC分类号： G01N33/54326 ,  G01N33/491 ,  G01N33/538 ,  G01N33/54313 ,  G01N33/56972

    摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

    摘要翻译： 公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。 该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够 特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。 在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域 收集室。 与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

    CELL ASSAY KIT AND METHOD
    5.
    发明申请
    CELL ASSAY KIT AND METHOD 有权
    细胞测定试剂盒和方法

    公开(公告)号：US20100311085A1

    公开(公告)日：2010-12-09

    申请号：US12859973

    申请日：2010-08-20

    申请人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus-Munoz ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    发明人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus-Munoz ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    IPC分类号： G01N33/50 ,  C12M1/34

    CPC分类号： G01N33/54326 ,  G01N33/491 ,  G01N33/538 ,  G01N33/54313 ,  G01N33/56972

    摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

    摘要翻译： 公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。 该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够 特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。 在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域 收集室。 与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

    CELL ASSAY KIT AND METHOD
    6.
    发明申请
    CELL ASSAY KIT AND METHOD 有权
    细胞测定试剂盒和方法

    公开(公告)号：US20090148869A1

    公开(公告)日：2009-06-11

    申请号：US12329380

    申请日：2008-12-05

    申请人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    发明人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

    IPC分类号： G01N33/53 ,  C12Q1/06 ,  G01N33/569 ,  C12M1/00

    CPC分类号： G01N33/54326 ,  G01N33/491 ,  G01N33/538 ,  G01N33/54313 ,  G01N33/56972

    摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

    摘要翻译： 公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。 该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够 特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。 在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域 收集室。 与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。