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公开(公告)号：US09453210B2
公开(公告)日：2016-09-27
申请号：US13260012
申请日：2010-02-23
申请人： Franz Ulrich Becker , Gerda Grund , Matthias Orschel , Kai Doderer , Gerd Loehden , Gerd Brand , Peter Duerre , Simone Thum , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May
发明人： Franz Ulrich Becker , Gerda Grund , Matthias Orschel , Kai Doderer , Gerd Loehden , Gerd Brand , Peter Duerre , Simone Thum , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May
CPC分类号： C12N9/13 , C12N9/1029 , C12N9/16 , C12N9/88 , C12P7/30 , C12Y203/01009 , Y02P20/52
摘要： The invention relates to cells and a method for producing acetone.
摘要翻译： 本发明涉及细胞和生产丙酮的方法。
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公开(公告)号：US20120101304A1
公开(公告)日：2012-04-26
申请号：US13260012
申请日：2010-02-23
申请人： Franz Ulrich Becker , Gerda Grund , Matthias Orschel , Kai Doderer , Gerd Löhden , Gerd Brand , Peter Dürre , Simone Thum , Hubert Johannes Bahl , Ralf-Jörg Fischer , Antje May
发明人： Franz Ulrich Becker , Gerda Grund , Matthias Orschel , Kai Doderer , Gerd Löhden , Gerd Brand , Peter Dürre , Simone Thum , Hubert Johannes Bahl , Ralf-Jörg Fischer , Antje May
CPC分类号： C12N9/13 , C12N9/1029 , C12N9/16 , C12N9/88 , C12P7/30 , C12Y203/01009 , Y02P20/52
摘要： The invention relates to cells and a method for producing acetone.
摘要翻译： 本发明涉及细胞和生产丙酮的方法。
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3.发明授权Fermentative production of acetone from renewable resources by means of novel metabolic pathway 有权通过新型代谢途径从可再生资源中发酵生产丙酮公开(公告)号：US08986961B2
公开(公告)日：2015-03-24
申请号：US12679488
申请日：2008-10-01
申请人： Stefan Verseck , Steffen Schaffer , Werner Freitag , Friedrich-Georg Schmidt , Matthias Orschel , Gerda Grund , Wilfried Schmidt , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May , Peter Duerre , Simone Lederle
发明人： Stefan Verseck , Steffen Schaffer , Werner Freitag , Friedrich-Georg Schmidt , Matthias Orschel , Gerda Grund , Wilfried Schmidt , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May , Peter Duerre , Simone Lederle
CPC分类号： C12P7/28 , C12N9/16 , C12N9/93 , C12Y301/02 , C12Y301/02018
摘要： The invention describes a process for preparing acetone starting from acetyl-coenzyme A comprising process steps A. enzymatic conversion of acetyl-CoA into acetoacetyl-CoA B. enzymatic conversion of acetoacetyl-CoA into acetoacetate and CoA and C. decarboxylation of acetoacetate to acetone and CO2, which is characterized in that the coenzyme A is not transferred in process step B to an acceptor molecule. In addition, process step B is surprisingly catalyzed by enzymes of the classes of acyl-CoA thioesterase, acyl-CoA synthetase or acyl-CoA thiokinase.A completely novel metabolic pathway is concerned, because the enzymatic hydrolysis of acetoacetyl-CoA without simultaneous transfer of CoA to a receptor molecule has never previously been described for any microbial enzyme.
摘要翻译： 本发明描述了从乙酰辅酶A开始制备丙酮的方法，包括方法步骤A.将乙酰辅酶A酶促转化为乙酰乙酰辅酶A.将乙酰乙酰辅酶A酶促转化为乙酰乙酸酯，并将乙酰乙酸酯脱羧至丙酮， CO 2，其特征在于辅酶A在工艺步骤B中不转移到受体分子。 此外，方法步骤B令人惊奇地由酰基-CoA硫酯酶，酰基辅酶A合成酶或酰基辅酶A硫代激酶类的酶催化。 关注一个完全新颖的代谢途径，因为乙酰乙酰辅酶A的酶水解而不会同时转移CoA到受体分子，从未以前没有描述任何微生物酶。
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4.发明申请公开(公告)号：US20100261237A1
公开(公告)日：2010-10-14
申请号：US12679488
申请日：2008-10-01
申请人： Stefan Verseck , Steffen Schaffer , Werner Freitag , Friedrich-Georg Schmidt , Matthias Orschel , Gerda Grund , Wilfried Schmidt , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May , Peter Duerre , Simone Lederle
发明人： Stefan Verseck , Steffen Schaffer , Werner Freitag , Friedrich-Georg Schmidt , Matthias Orschel , Gerda Grund , Wilfried Schmidt , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May , Peter Duerre , Simone Lederle
CPC分类号： C12P7/28 , C12N9/16 , C12N9/93 , C12Y301/02 , C12Y301/02018
摘要： The invention describes a process for preparing acetone starting from acetyl-coenzyme A comprising process steps A. enzymatic conversion of acetyl-CoA into acetoacetyl-CoA B. enzymatic conversion of acetoacetyl-CoA into acetoacetate and CoA and C. decarboxylation of acetoacetate to acetone and CO2, which is characterized in that the coenzyme A is not transferred in process step B to an acceptor molecule. In addition, process step B is surprisingly catalysed by enzymes of the classes of acyl-CoA thioesterase, acyl-CoA synthetase or acyl-CoA thiokinase.A completely novel metabolic pathway is concerned, because the enzymatic hydrolysis of acetoacetyl-CoA without simultaneous transfer of CoA to a receptor molecule has never previously been described for any microbial enzyme.
摘要翻译： 本发明描述了从乙酰辅酶A开始制备丙酮的方法，包括方法步骤A.将乙酰辅酶A酶促转化为乙酰乙酰辅酶A.将乙酰乙酰辅酶A酶促转化为乙酰乙酸酯，并将乙酰乙酸酯脱羧至丙酮， CO 2，其特征在于辅酶A在工艺步骤B中不转移到受体分子。 此外，工艺步骤B由酰基-CoA硫酯酶，酰基辅酶A合成酶或酰基辅酶A硫代激酶类的催化剂惊人地催化。 关注一个完全新颖的代谢途径，因为乙酰乙酰辅酶A的酶水解而不会同时转移CoA到受体分子，从未以前没有描述任何微生物酶。
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公开(公告)号：US08889914B2
公开(公告)日：2014-11-18
申请号：US13990602
申请日：2011-11-17
申请人： Matthias Orschel , Robert Jansen , Martin Maier , Gerda Grund , Markus Schwarz , Joerg-Joachim Nitz , Axel Hengstermann
发明人： Matthias Orschel , Robert Jansen , Martin Maier , Gerda Grund , Markus Schwarz , Joerg-Joachim Nitz , Axel Hengstermann
CPC分类号： C07C45/42 , C07C45/74 , C07C45/82 , C07C45/85 , C07C2601/16 , Y02P20/582 , C07C49/603
摘要： The invention relates to a method for producing isophorone by catalyzed aldol condensation of acetone as an educt, reprocessing the reaction product, hydrolyzing the product stream, and separating into an organic and an aqueous fraction, obtaining isophorone from the organic fraction, distillatively reprocessing the aqueous fraction, and feeding the vapors from the head of the distillative reprocessing apparatus into the hydrolysis apparatus.
摘要翻译： 本发明涉及通过丙酮作为离子液体的催化醛醇缩合制备异佛尔酮的方法，对反应产物进行后处理，水解产物流，并分离成有机和含水部分，从有机部分获得异佛尔酮，蒸馏再处理含水 并将蒸气从蒸馏后处理装置的头部进料到水解装置中。
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6.发明申请公开(公告)号：US20130261341A1
公开(公告)日：2013-10-03
申请号：US13885532
申请日：2011-11-17
IPC分类号： C07C209/52
CPC分类号： C07C209/52 , C07C209/26 , C07C209/48 , C07C2601/14 , C07C211/36
摘要： The invention relates to an improved process for preparing 3-aminomethyl-3,5,5-trimethylcyclohexylamine, referred to hereinafter as isophoronediamine or IPDA for short, by means of catalytic hydrogenation and/or catalytic reductive amination (also referred to as aminating hydrogenation) of 3-cyano-3,5,5-trimethylcyclohexanone, also called isophoronenitrile or IPN for short hereinafter.
摘要翻译： 本发明涉及通过催化氢化和/或催化还原胺化（也称为胺化氢化）制备3-氨基甲基-3,5,5-三甲基环己胺（以下称为异佛尔酮二胺或简称为IPDA）的改进方法， 的3-氰基-3,5,5-三甲基环己酮，以下简称为异佛尔酮腈或IPN。
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7.发明授权公开(公告)号：US09085506B2
公开(公告)日：2015-07-21
申请号：US13991718
申请日：2011-11-18
申请人： Markus Galle , Gerda Grund , Axel Hengstermann , Michael D Hinton , Rolf Hirsch , Robert Jansen , Cord Knoop , Christian Lettmann , Juergen Lippe , Martin Maier , Joerg-Joachim Nitz , Matthias Orschel , Martina Ortelt , Norbert Richter , Armin Rix , Markus Schwarz , Guido Streukens
发明人： Markus Galle , Gerda Grund , Axel Hengstermann , Michael D Hinton , Rolf Hirsch , Robert Jansen , Cord Knoop , Christian Lettmann , Juergen Lippe , Martin Maier , Joerg-Joachim Nitz , Matthias Orschel , Martina Ortelt , Norbert Richter , Armin Rix , Markus Schwarz , Guido Streukens
IPC分类号： C07C209/00 , C07C209/48 , C07C209/26 , C07C253/10 , C07C45/74
CPC分类号： C07C209/48 , C07C45/74 , C07C209/26 , C07C253/10 , C07C2601/14 , Y02P20/127 , Y02P20/582 , C07C211/36 , C07C255/46 , C07C49/603
摘要： The invention relates to an improved process for preparing 3-aminomethyl-3,5,5-trimethylcyclohexylamine, referred to hereinafter as isophoronediamine or, in abbreviated form, IPDA, by: I. preparation of isophorone by catalyzed aldol condensations with acetone as reactant; II. reaction of isophorone with HCN to form isophoronenitrile (IPN, 3-cyano-3,5,5-trimethylcyclohexanone); III. catalytic hydrogenation and/or catalytic reductive amination (also referred to as aminative hydrogenation) of 3-cyano-3,5,5-trimethylcyclohexanone, hereinafter called isophoronenitrile or, in abbreviated form, IPN, to give the isophoronediamine.
摘要翻译： 本发明涉及一种改进的3-氨基甲基-3,5,5-三甲基环己胺的制备方法，以下称为异佛尔酮二胺或缩写形式为IPDA，通过以下方法：I.通过丙酮作为反应物的催化醛醇缩合制备异佛尔酮; 二， 异佛尔酮与HCN的反应形成异佛尔酮腈（IPN，3-氰基-3,5,5-三甲基环己酮）; 三， 3-氰基-3,5,5-三甲基环己酮的催化氢化和/或催化还原胺化（也称为氨基氢化），以下称为异佛尔酮腈或缩写为IPN，得到异佛尔酮二胺。
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8.发明授权公开(公告)号：US08877976B2
公开(公告)日：2014-11-04
申请号：US13885532
申请日：2011-11-17
IPC分类号： C07C209/00 , C07C209/48 , C07C209/52
CPC分类号： C07C209/52 , C07C209/26 , C07C209/48 , C07C2601/14 , C07C211/36
摘要： The invention relates to an improved process for preparing 3-aminomethyl-3,5,5-trimethylcyclohexylamine, referred to hereinafter as isophoronediamine or IPDA for short, by means of catalytic hydrogenation and/or catalytic reductive amination (also referred to as aminating hydrogenation) of 3-cyano-3,5,5-trimethylcyclohexanone, also called isophoronenitrile or IPN for short hereinafter.
摘要翻译： 本发明涉及通过催化氢化和/或催化还原胺化（也称为氨化氢化）制备3-氨基甲基-3,5,5-三甲基环己胺（以下称为异佛尔酮二胺或简称为IPDA）的改进方法， 的3-氰基-3,5,5-三甲基环己酮，以下简称为异佛尔酮腈或IPN。
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公开(公告)号：US20130261343A1
公开(公告)日：2013-10-03
申请号：US13990602
申请日：2011-11-17
申请人： Matthias Orschel , Robert Jansen , Martin Maier , Gerda Grund , Markus Schwarz , Joerg-Joachim Nitz , Axel Hengstermann
发明人： Matthias Orschel , Robert Jansen , Martin Maier , Gerda Grund , Markus Schwarz , Joerg-Joachim Nitz , Axel Hengstermann
IPC分类号： C07C45/42
CPC分类号： C07C45/42 , C07C45/74 , C07C45/82 , C07C45/85 , C07C2601/16 , Y02P20/582 , C07C49/603
摘要： The invention relates to a method for producing isophorone by catalyzed aldol condensation of acetone as an educt, reprocessing the reaction product, hydrolyzing the product stream, and separating into an organic and an aqueous fraction, obtaining isophorone from the organic fraction, distillatively reprocessing the aqueous fraction, and feeding the vapors from the head of the distillative reprocessing apparatus into the hydrolysis apparatus.
摘要翻译： 本发明涉及通过丙酮作为离子液体的催化醛醇缩合制备异佛尔酮的方法，对反应产物进行后处理，水解产物流，并分离成有机和含水部分，从有机部分获得异佛尔酮，蒸馏再处理含水 并将蒸气从蒸馏后处理装置的头部进料到水解装置中。
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10.发明申请公开(公告)号：US20130253226A1
公开(公告)日：2013-09-26
申请号：US13991718
申请日：2011-11-18
申请人： Markus Galle , Gerda Grund , Axel Hengstermann , Michael D. Hinton , Rolf Hirsch , Robert Jansen , Cord Knoop , Christian Lettmann , Juergen Lippe , Martin Maier , Joerg-Joachim Nitz , Matthias Orschel , Martina Ortelt , Norbert Richter , Armin Rix , Markus Schwarz , Guido Streukens
发明人： Markus Galle , Gerda Grund , Axel Hengstermann , Michael D. Hinton , Rolf Hirsch , Robert Jansen , Cord Knoop , Christian Lettmann , Juergen Lippe , Martin Maier , Joerg-Joachim Nitz , Matthias Orschel , Martina Ortelt , Norbert Richter , Armin Rix , Markus Schwarz , Guido Streukens
IPC分类号： C07C209/48
CPC分类号： C07C209/48 , C07C45/74 , C07C209/26 , C07C253/10 , C07C2601/14 , Y02P20/127 , Y02P20/582 , C07C211/36 , C07C255/46 , C07C49/603
摘要： The invention relates to an improved process for preparing 3-aminomethyl-3,5,5-trimethylcyclohexylamine, referred to hereinafter as isophoronediamine or, in abbreviated form, IPDA, by: I. preparation of isophorone by catalyzed aldol condensations with acetone as reactant; II. reaction of isophorone with HCN to form isophoronenitrile (IPN, 3-cyano-3,5,5-trimethylcyclohexanone); III. catalytic hydrogenation and/or catalytic reductive amination (also referred to as aminative hydrogenation) of 3-cyano-3,5,5-trimethylcyclohexanone, hereinafter called isophoronenitrile or, in abbreviated form, IPN, to give the isophoronediamine.
摘要翻译： 本发明涉及一种改进的3-氨基甲基-3,5,5-三甲基环己胺的制备方法，以下称为异佛尔酮二胺或缩写形式为IPDA，通过以下方法：I.通过丙酮作为反应物的催化醛醇缩合制备异佛尔酮; 二， 异佛尔酮与HCN的反应形成异佛尔酮腈（IPN，3-氰基-3,5,5-三甲基环己酮）; 三， 3-氰基-3,5,5-三甲基环己酮的催化氢化和/或催化还原胺化（也称为氨基氢化），以下称为异佛尔酮腈或缩写为IPN，得到异佛尔酮二胺。
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