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公开(公告)号:US20160187293A1
公开(公告)日:2016-06-30
申请号:US14124986
申请日:2012-06-11
申请人: Frederic ZENHAUSERN , Alan NORDQUIST , Ralf LENIGK , Cedric HURTH , Jianing YANG , Xiaojia CHEN , Matthew ESTES , John LEE-EDGHILL , Nina MORAN , Andrew HOPWOOD , Pieris KOUMI
发明人: Frederic ZENHAUSERN , Alan NORDQUIST , Ralf LENIGK , Cedric HURTH , Jianing YANG , Xiaojia CHEN , Matthew ESTES , John LEE-EDGHILL , Nina MORAN , Andrew HOPWOOD , Pieris KOUMI
IPC分类号: G01N27/447
CPC分类号: G01N27/44756
摘要: An electrophoresis device where the end of the electrophoresis channel has a part that extends vertically. The electrophoresis channel includes a first access port at one end of the channel and a second port at the other end of the channel, which are in the same horizontal plane. In this way, there is a less than 0.1% hydrostatic pressure differential between two ports and the performance of the device is improved.
摘要翻译: 一种电泳装置,其中电泳通道的末端具有垂直延伸的部分。 电泳通道包括在通道的一端的第一进入口和处于相同水平面的通道的另一端的第二端口。 以这种方式,两个端口之间的静水压差小于0.1%,提高了设备的性能。
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公开(公告)号:US20130130365A1
公开(公告)日:2013-05-23
申请号:US13649852
申请日:2012-10-11
申请人: Frederic ZENHAUSERN , Alan NORDQUIST , Ralf LENIGK , Cedric HURTH , Jianing YANG , Xiaojia CHEN , Matthew ESTES , John LEE-EDGHILL , Nina MORAN , Andrew HOPWOOD , Pieris KOUMI
发明人: Frederic ZENHAUSERN , Alan NORDQUIST , Ralf LENIGK , Cedric HURTH , Jianing YANG , Xiaojia CHEN , Matthew ESTES , John LEE-EDGHILL , Nina MORAN , Andrew HOPWOOD , Pieris KOUMI
CPC分类号: B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要: A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the device and method of use are also provided which offer reliable performance of a heating based process, with minimal condensation and/or sample loss issues.
摘要翻译: 提供了一种分析方法,用于分析仪器和用于这种仪器的设备,其执行许多过程需要在各种样品的上下文中获得有用的结果。 这些过程的顺序被优化。 还提供了使用该装置和使用方法的装置,仪器,其具有基于加热的工艺的可靠性能,具有最小的冷凝和/或样品损失问题。
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公开(公告)号:US20140186841A1
公开(公告)日:2014-07-03
申请号:US14034153
申请日:2013-09-23
申请人: Frederic ZENHAUSERN , Ralf LENIGK , Jianing YANG , Zhi CAI , Alan NORDQUIST , Stanley D. SMITH , David MAGGIANO , Glen MCCARTY , Mrinalini PRASAD , Karem LINAN , Baiju THOMAS , Edward OLAYA , Cedric HURTH , Darryl COX , Mark RICHARD
发明人: Frederic ZENHAUSERN , Ralf LENIGK , Jianing YANG , Zhi CAI , Alan NORDQUIST , Stanley D. SMITH , David MAGGIANO , Glen MCCARTY , Mrinalini PRASAD , Karem LINAN , Baiju THOMAS , Edward OLAYA , Cedric HURTH , Darryl COX , Mark RICHARD
IPC分类号: C12Q1/68
CPC分类号: C12Q1/686 , B01L3/5027 , B01L7/52 , B01L2200/10 , B01L2200/143 , B01L2300/0816 , B01L2300/1827 , B01L2400/0421 , B01L2400/0672 , B01L2400/0677 , G01N2035/00158
摘要: A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying, separating, detecting, generating, comparing, and identifying are performed automatically without user interaction.
摘要翻译: 用于分析生物样品的方法,系统和装置包括接收样品,其中样品包括脱氧核糖核酸(DNA),裂解样品以获得样品中包含的DNA,纯化样品中的DNA以分离 来自样品中的其他成分的DNA,扩增DNA,分离扩增的DNA片段,使用激光诱导的荧光检测分离的片段,基于检测,产生所接收的样品中DNA的谱,比较生成的分布与 存储在数据库中的DNA的简档,以及在确定生成的简档与所存储的简档中的一个匹配时,识别从其获得存储的简档的源,其中对相应部分执行接收,裂解,净化,放大和检测 的微流体装置,并且其中将样品和DNA运输到微流体装置的部分并且使得能够进行裂解, 净化,放大,分离,检测,生成,比较和识别是自动执行的,无需用户交互。
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