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公开(公告)号：US07285382B2
公开(公告)日：2007-10-23
申请号：US10182033
申请日：2001-01-25
IPC分类号： C12Q1/70
CPC分类号： C07K14/47 , A61K2039/505 , C07K14/4748 , C07K16/30 , C07K2317/34 , G01N33/57415 , G01N33/57484
摘要： The present invention concerns compositions and methods for the treatment of disorders characterized by the over-expression of an LIV-1. More specifically, the compositions include DNA and amino acid sequences of an LIV-1, antibodies to an LIV-1, and methods for the treatment of a mammal susceptible to or diagnosed with cancer wherein an LIV-1 is overexpressed.
摘要翻译： 本发明涉及用于治疗特征在于LIV-1过度表达的疾病的组合物和方法。 更具体地，组合物包括LIV-1的DNA和氨基酸序列，LIV-1的抗体，以及用于治疗敏感或诊断为癌症的哺乳动物的方法，其中LIV-1被过表达。
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公开(公告)号：US07691566B2
公开(公告)日：2010-04-06
申请号：US11538881
申请日：2006-10-05
IPC分类号： C12Q1/70
CPC分类号： C07K14/47 , A61K2039/505 , C07K14/4748 , C07K16/30 , C07K2317/34 , G01N33/57415 , G01N33/57484
摘要： The present invention concerns compositions and methods for the treatment of disorders characterized by the overexpression of an LIV-1. More specifically, the compositions include DNA and amino acid sequences of an LIV-1, antibodies to an LIV-1, and methods for the treatment of a mammal susceptible to or diagnosed with cancer wherein an LIV-1 is overexpressed.
摘要翻译： 本发明涉及用于治疗特征在于LIV-1过表达的疾病的组合物和方法。 更具体地，组合物包括LIV-1的DNA和氨基酸序列，LIV-1的抗体，以及用于治疗敏感或诊断为癌症的哺乳动物的方法，其中LIV-1被过表达。
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3.发明授权Nucleic acids encoding PRO6308 polypeptides and related vectors and host cells 有权编码PRO6308多肽和相关载体和宿主细胞的核酸公开(公告)号：US07795412B2
公开(公告)日：2010-09-14
申请号：US12077504
申请日：2008-03-18
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07777007B2
公开(公告)日：2010-08-17
申请号：US10219533
申请日：2002-08-14
申请人： Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
发明人： Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
IPC分类号： C07K16/00
CPC分类号： C07K14/705 , C07K14/47 , G01N33/574
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07718770B2
公开(公告)日：2010-05-18
申请号：US10183012
申请日：2002-06-26
申请人： Kevin P. Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Victoria Smith , Colin K. Watanabe , William I. Wood , Zemin Zhang
发明人： Kevin P. Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Victoria Smith , Colin K. Watanabe , William I. Wood , Zemin Zhang
IPC分类号： C07K14/435 , C07H21/00
CPC分类号： C07K14/47 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/00 , C07K16/18 , C07K16/28 , C07K2319/30 , C12N9/90 , C12N2799/026 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5082 , G01N33/5308 , G01N33/574 , G01N33/57411 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2500/10 , C12Q2563/131 , C12Q2527/137
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07718173B2
公开(公告)日：2010-05-18
申请号：US10142885
申请日：2002-05-10
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K1/00 , C07K14/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K14/82 , C07K16/18 , C07K17/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N5/06 , C12N9/00 , C12N9/001 , C12N9/1051 , C12N15/00 , C12N2799/026 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6845 , G01N2800/042 , Y10S530/828 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07709603B2
公开(公告)日：2010-05-04
申请号：US10187591
申请日：2002-07-01
IPC分类号： C07K1/00
CPC分类号： C07K14/47 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/28 , C07K2319/30 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5082 , G01N33/5308 , G01N33/574 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2500/00 , C12Q2563/131 , C12Q2527/137
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07700736B2
公开(公告)日：2010-04-20
申请号：US10123322
申请日：2002-04-15
申请人： Kevin P. Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Steven Sherwood , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood , Zemin Zhang
发明人： Kevin P. Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Steven Sherwood , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood , Zemin Zhang
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K1/00 , C07K14/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K14/82 , C07K16/18 , C07K17/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N5/06 , C12N9/00 , C12N9/001 , C12N9/1051 , C12N15/00 , C12N2799/026 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6845 , G01N2800/042 , Y10S530/828 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20090226953A1
公开(公告)日：2009-09-10
申请号：US12270133
申请日：2008-11-13
申请人： Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
发明人： Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
CPC分类号： C07K14/705 , C07K14/47 , G01N33/574
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07495083B2
公开(公告)日：2009-02-24
申请号：US10176918
申请日：2002-06-20
CPC分类号： C07K14/47 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/00 , C07K16/18 , C07K16/28 , C07K2319/30 , C12N9/90 , C12N2799/026 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5082 , G01N33/5308 , G01N33/574 , G01N33/57411 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2500/10 , C12Q2563/131 , C12Q2527/137
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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