公开(公告)号：US5017571A

公开(公告)日：1991-05-21

申请号：US317016

申请日：1989-02-28

申请人： Kristian T. Hansen ,  Hans Bundgaard ,  Peter Faarup

发明人： Kristian T. Hansen ,  Hans Bundgaard ,  Peter Faarup

IPC分类号： C07D223/16 ,  A61K31/55 ,  A61P25/00 ,  C07D401/04 ,  C07D403/12 ,  C07D405/04 ,  C07D409/04

CPC分类号： C07D401/04 ,  C07D405/04 ,  C07D409/04

摘要： Compounds having the formula ##STR1## wherein R.sup.1, R.sup.4, R.sup.6, R.sup.7, and R.sup.8 are hydrogen or a substituent, R.sup.2 is a substituent, R.sup.5 is an optionally-substituted bicyclic ring system, especially a 7-benzofuranyl or 2,3-dihydrobenzofuran-7-yl substituent, R.sup.9 is hydrogen, alkyl, alkoxycarbonyl or, together with R.sup.8, forms the remainder of a heterocyclic ring, their pharmaceutically-accceptable salts, as well as their pharmaceutical compositions and use as prodrugs for compounds active for the treatment of mental disorders, are disclosed.

公开(公告)号：US5010074A

公开(公告)日：1991-04-23

申请号：US365250

申请日：1989-06-12

申请人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

发明人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  C07D223/14 ,  C07D223/16 ,  C07D405/04 ,  C07D491/052 ,  C07D491/153 ,  C07D495/04

CPC分类号： C07D223/16 ,  C07D223/14 ,  C07D405/04

摘要： Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl; R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --;R.sup.7 represent hydroxy, lower alkoxy;R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or alkoxy or trifluoromethyl, or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among --O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-CH.dbd.CH--, --CH.sub.2 -CH.sub.2 -CH.sub.2 --, --CH.sub.2 -CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --;R.sup.13 represents hydrogen, halogen or lower alkyl.The compounds are useful in preparations for treatment of disorders in the central nervous system.

公开(公告)号：US5025009A

公开(公告)日：1991-06-18

申请号：US477450

申请日：1990-02-07

申请人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

发明人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  C07D223/14 ,  C07D223/16 ,  C07D405/04 ,  C07D491/052 ,  C07D491/153 ,  C07D495/04

CPC分类号： C07D223/16 ,  C07D223/14 ,  C07D405/04

摘要： Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl;R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --;R.sup.7 represents hydroxy, lower alkoxy;R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among--O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O--CH.dbd.CH--, --CH.sub.2, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --;R-- represents hydrogen, halogen or lower alkyl.The compounds are useful in preparations for treatment of disorders in the central nervous system.

公开(公告)号：US06653492B2

公开(公告)日：2003-11-25

申请号：US10141469

申请日：2002-05-01

申请人： Peter Faarup

发明人： Peter Faarup

IPC分类号： C07J900

CPC分类号： C07J9/00

摘要： Certain bile acids find use in the pharmaceutical industry. In view of the wide distribution of serious diseases such as HIV, AIDS and Bovine Spongiform Encephalopathy (BSE) it is desirable to avoid—as far as practicable—to have any components of animal origin in medicaments in order to eliminate any danger of infection. The present invention relates to a method of providing bile acids from non-animal starting materials.

公开(公告)号：US06645953B2

公开(公告)日：2003-11-11

申请号：US09878884

申请日：2001-06-11

申请人： Frederik Christian Gronvald ,  Peter Faarup ,  Erling Guddal

发明人： Frederik Christian Gronvald ,  Peter Faarup ,  Erling Guddal

IPC分类号： A61K3156

CPC分类号： C07J9/00 ,  C07J41/0016 ,  Y10S514/841 ,  Y10S514/842 ,  Y10S514/843

摘要： Sterol derivative compounds, structurally related to natural compounds which can be extracted from bull testes and from human follicular fluid, useful for regulating meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives.

公开(公告)号：US06884796B2

公开(公告)日：2005-04-26

申请号：US10162843

申请日：2002-06-04

申请人： Peter Faarup ,  Frederick Christian Grønvald ,  Thorsten Blume ,  Anthony Murray ,  Jens Breinholt

发明人： Peter Faarup ,  Frederick Christian Grønvald ,  Thorsten Blume ,  Anthony Murray ,  Jens Breinholt

IPC分类号： A61K31/575 ,  A61P43/00 ,  C07J9/00 ,  C07J21/00 ,  C07J41/00 ,  C07J43/00 ,  C07J53/00 ,  A61K31/56

CPC分类号： C07J41/0094 ,  C07J9/00 ,  C07J53/004

摘要： Certain novel sterol derivatives can be used for regulating the meiosis in oocytes and in male germ cells.

公开(公告)号：US5227488A

公开(公告)日：1993-07-13

申请号：US590393

申请日：1990-09-28

申请人： Lone Jeppesen ,  Peter H. Andersen ,  Louis B. Hansen ,  Peter Faarup ,  John B. Hansen

发明人： Lone Jeppesen ,  Peter H. Andersen ,  Louis B. Hansen ,  Peter Faarup ,  John B. Hansen

IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/435 ,  A61P25/00 ,  A61P25/18 ,  C07D209/48 ,  C07D209/66 ,  C07D209/70 ,  C07D209/76 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D491/08 ,  C07D491/18 ,  C07D495/18

CPC分类号： C07D209/48 ,  C07D209/66 ,  C07D209/70 ,  C07D209/76 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

摘要： Indole derivatives of formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen or lower alkyl optionally substituted by halogen; X represents oxygen or sulfur; A.sup.1 represents a straight or branched alkylene chain containing from 2 to 4 carbon atoms; R.sup.5 is hydrogen or a straight or branched alkyl group; A.sup.2 is a straight or branched, saturated or unsaturated hydrocarbon chain containing from 2 to 6 carbon atoms; and R.sup.6 is selected from a group consisting of various structures, have been found to exhibit central nervous system activities.

摘要翻译： 式（I）的吲哚衍生物其中R 1，R 2，R 3和R 4可以是氢或任选被卤素取代的低级烷基; X表示氧或硫; A1表示含有2至4个碳原子的直链或支链亚烷基链; R5是氢或直链或支链烷基; A2是含有2至6个碳原子的直链或支链，饱和或不饱和烃链; 并且R6被选自由各种结构组成的组，已被发现显示出中枢神经系统活性。

公开(公告)号：US5166155A

公开(公告)日：1992-11-24

申请号：US667855

申请日：1991-03-12

申请人： Anker S. Jorgensen ,  Carsten E. Stidsen ,  Peter Faarup ,  Frederik S. Gronvald

发明人： Anker S. Jorgensen ,  Carsten E. Stidsen ,  Peter Faarup ,  Frederik S. Gronvald

IPC分类号： A61K31/495 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  C07D241/44 ,  C07D241/52

CPC分类号： C07D241/52 ,  C07D241/44

摘要： 1-carboxyalkylquinoxaline-2,3(1H,4H)-dione compounds or tautomeric forms thereof of the formula ##STR1## wherein R represents hydrogen, C.sub.1-6 -alkyl, including branched chains, or aralkyl and n represents the number from 0 to 5;R.sup.4 represents hydrogen or hydroxy;R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently represent hydrogen, nitro, halogen, alkoxy, aryloxy, aralkoxy, C.sub.1-6 -alkyl including branched chains, or aryl;R.sup.9 represents hydrogen, lower alkyl, or aryl;R.sup.10 represents hydrogen, or alkyl.The compounds are useful in the treatment of neurological and psychiatric diseases.

摘要翻译： 1-羧基烷基喹喔啉-2,3（1H，4H） - 二酮化合物或其互变异构形式，其中R表示氢，C 1-6 - 烷基，包括支链或芳烷基，n表示0至 5; R4表示氢或羟基; R5，R6，R7和R8独立地表示氢，硝基，卤素，烷氧基，芳氧基，芳烷氧基，包括支链的C1-6烷基或芳基; R9代表氢，低级烷基或芳基; R 10表示氢或烷基。 该化合物可用于治疗神经和精神疾病。

公开(公告)号：US3994883A

公开(公告)日：1976-11-30

申请号：US427363

申请日：1973-12-21

申请人： Poul Borrevang ,  Erling Guddal ,  Henning Borge Petersen ,  Peter Faarup ,  Jorgen Ilum Nielsen

发明人： Poul Borrevang ,  Erling Guddal ,  Henning Borge Petersen ,  Peter Faarup ,  Jorgen Ilum Nielsen

IPC分类号： C07D499/00 ,  C07D499/12 ,  C07D499/42 ,  C07D501/06 ,  C07D501/18 ,  C07F9/6561 ,  C07D499/02

CPC分类号： C07D499/00 ,  C07F9/65611 ,  C07F9/65613

摘要： Novel penicillin and cephalosporin intermediates for the synthesis of 6-APA or 7-aminocephem compounds involving formation of a 6 or 7 phosphite amido compound and the conversion of such compound to a desired 6-APA or 7-aminocephem compound.

摘要翻译： 用于合成涉及形成6或7亚磷酸酰胺化合物的6-APA或7-氨基头孢烯化合物的新型青霉素和头孢菌素中间体以及将该化合物转化为所需的6-APA或7-氨基头孢烯化合物。

公开(公告)号：US06759400B2

公开(公告)日：2004-07-06

申请号：US10242381

申请日：2002-09-11

申请人： Christian Grondahl ,  Frederik Christian Gronvald ,  Peter Faarup ,  Anthony Murray ,  Jan Lund Ottesen

发明人： Christian Grondahl ,  Frederik Christian Gronvald ,  Peter Faarup ,  Anthony Murray ,  Jan Lund Ottesen

IPC分类号： A61K3156

CPC分类号： C07J9/00 ,  Y10S514/841

摘要： Certain compounds, structurally related to natural compounds which can be extracted i.a. from bull testes and from human follicular fluid, can be used for regulating the meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives. These compounds have the structural formula wherein the substituents are as defined in the specification.

摘要翻译： 某些化合物，结构上与可以提取的天然化合物有关 来自公牛睾丸和人卵泡液，可用于调节卵母细胞和雄性生殖细胞中的减数分裂。 这些化合物中的一些可用于治疗不育症，而其他化合物可用作避孕药具。 这些化合物具有结构式，其取代基如说明书中所定义。