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公开(公告)号：US08526453B2
公开(公告)日：2013-09-03
申请号：US11752639
申请日：2007-05-23
IPC分类号： H04L12/28
CPC分类号： H04Q3/545 , H04Q2213/13003 , H04Q2213/13034 , H04Q2213/1305 , H04Q2213/13107 , H04Q2213/13389 , H04Q2213/13396
摘要： Linecards and methods for processing signals are provided.
摘要翻译： 提供了线路卡和处理信号的方法。
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公开(公告)号：US20070274333A1
公开(公告)日：2007-11-29
申请号：US11752639
申请日：2007-05-23
IPC分类号： H04L12/56
CPC分类号： H04Q3/545 , H04Q2213/13003 , H04Q2213/13034 , H04Q2213/1305 , H04Q2213/13107 , H04Q2213/13389 , H04Q2213/13396
摘要： Linecards and methods for processing signals are provided.
摘要翻译： 提供了线路卡和处理信号的方法。
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公开(公告)号：US20130177640A1
公开(公告)日：2013-07-11
申请号：US13808087
申请日：2011-06-07
申请人： Andrew Geall , Katrin Ramsauer , Gillis Otten , Christian Mandl
发明人： Andrew Geall , Katrin Ramsauer , Gillis Otten , Christian Mandl
IPC分类号： A61K31/7088
CPC分类号： A61K31/7088 , A61K39/12 , A61K39/155 , A61K2039/5256 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , C12N15/111 , C12N2320/32 , C12N2760/18534 , C12N2770/36143
摘要： RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.
摘要翻译： 编码免疫原的RNA在递送部位共同递送到非免疫细胞，并且还可以渗入到递送部位的免疫细胞。 这两种细胞类型对相同递送的RNA的反应导致两种不同的作用，其相互作用以产生针对免疫原的强烈免疫应答。 非免疫细胞翻译RNA并表达免疫原。 渗透性免疫细胞通过表达产生局部佐剂作用的I型干扰素和促炎细胞因子来响应RNA，其作用于表达免疫原的非免疫细胞上调主要组织相容性复合物表达，从而增加翻译的蛋白质向T 细胞。 对免疫细胞和非免疫细胞的影响可以通过单次递送单个RNA来实现。 通过单次注射。
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公开(公告)号：US08784839B2
公开(公告)日：2014-07-22
申请号：US13048412
申请日：2011-03-15
申请人： Franz Xaver Heinz , Christian Mandl
发明人： Franz Xaver Heinz , Christian Mandl
CPC分类号： C07K14/005 , A61K35/13 , A61K2039/5254 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24161
摘要： Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterized in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4 successive amino acids, wherein the carboxy-terminal hydrophobic region is not affected by the deletion.
摘要翻译： 公开了一种包含黄病毒突变体的减毒黄病毒活疫苗，其特征在于黄病毒突变体在衣壳蛋白中具有至少大于4个连续氨基酸的缺失，其中羧基末端疏水区不受缺失影响。
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5.发明授权Flaviviridae mutants comprising a deletion in the capsid protein for use as vaccines 失效在衣壳蛋白中含有缺失的黄病毒科突变体用作疫苗公开(公告)号：US08715999B2
公开(公告)日：2014-05-06
申请号：US12866631
申请日：2009-02-06
申请人： Franz X. Heinz , Christian Mandl , Petra Schlick , Andreas Meinke
发明人： Franz X. Heinz , Christian Mandl , Petra Schlick , Andreas Meinke
CPC分类号： C07K14/005 , A61K35/13 , A61K2039/5254 , C12N7/00 , C12N2770/24122 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention relates to a mutant virus of the family flaviviridae, comprising a deletion in the capsid protein of at least 20 successive amino acids, without any further deletion, substitution or insertion mutation except of the amino acids next to the deletion, which may be substituted.
摘要翻译： 本发明涉及一种黄病毒科的突变病毒，其包含至少20个连续氨基酸的衣壳蛋白中的缺失，除了缺失之外的氨基酸之外，没有任何进一步的缺失，取代或插入突变，其可以是 取代。
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公开(公告)号：US20110300205A1
公开(公告)日：2011-12-08
申请号：US12831252
申请日：2010-07-06
申请人： Andrew Geall , Armin Hekele , Christian Mandl
发明人： Andrew Geall , Armin Hekele , Christian Mandl
IPC分类号： A61K9/127 , C12N5/071 , A61K9/14 , A61P37/04 , A61K39/00 , A61K31/7088 , A61K48/00 , A61P31/00 , C07H21/02 , A61K9/50
CPC分类号： A61K39/00 , A61K2039/53 , A61K2039/55555 , C12N15/113 , C12N15/86 , C12N2310/123 , C12N2770/36143
摘要： This application discloses self-replicating RNA molecules that contain modified nucleotides, compositions that contain the self-replicating RNA molecules, and methods for using the self-replicating RNA molecules, for example, to raise an immune response.
摘要翻译： 本申请公开了含有修饰的核苷酸的自我复制的RNA分子，含有自我复制的RNA分子的组合物，以及使用自我复制的RNA分子的方法，例如提高免疫应答。
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7.发明申请Flaviviridae Mutants Comprising a Deletion in the Capsid Protein for Use as Vaccines 失效黄病毒科突变体包括用作疫苗的衣壳蛋白中的缺失公开(公告)号：US20100323003A1
公开(公告)日：2010-12-23
申请号：US12866631
申请日：2009-02-06
申请人： Franz X. Heinz , Christian Mandl , Petra Schlick , Andreas Meinke
发明人： Franz X. Heinz , Christian Mandl , Petra Schlick , Andreas Meinke
IPC分类号： A61K9/127 , A61K39/12 , A61K35/76 , C12P19/34 , C12N7/01 , A61K38/16 , A61K31/7088 , C07K14/005 , C07H21/04
CPC分类号： C07K14/005 , A61K35/13 , A61K2039/5254 , C12N7/00 , C12N2770/24122 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention relates to a mutant virus of the family flaviviridae, comprising a deletion in the capsid protein of at least 20 successive amino acids, without any further deletion, substitution or insertion mutation except of the amino acids next to the deletion, which may be substituted.
摘要翻译： 本发明涉及一种黄病毒科的突变病毒，其包含至少20个连续氨基酸的衣壳蛋白中的缺失，除了缺失之外的氨基酸之外，没有任何进一步的缺失，取代或插入突变，其可以是 取代。
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公开(公告)号：US09770463B2
公开(公告)日：2017-09-26
申请号：US13808087
申请日：2011-06-07
申请人： Andrew Geall , Katrin Ramsauer , Gillis Otten , Christian Mandl
发明人： Andrew Geall , Katrin Ramsauer , Gillis Otten , Christian Mandl
IPC分类号： A61K31/7088 , C12N15/11 , A61K39/155 , A61K39/12 , A61K39/00
CPC分类号： A61K31/7088 , A61K39/12 , A61K39/155 , A61K2039/5256 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , C12N15/111 , C12N2320/32 , C12N2760/18534 , C12N2770/36143
摘要： RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.
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公开(公告)号：US08486419B2
公开(公告)日：2013-07-16
申请号：US10450649
申请日：2002-02-11
申请人： Franz Xaver Heinz , Christian Mandl
发明人： Franz Xaver Heinz , Christian Mandl
CPC分类号： C07K14/005 , A61K35/13 , A61K2039/5254 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24161
摘要： Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterized in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4 successive amino acids, wherein the carboxy-terminal hydrophobic region is not affected by the deletion.
摘要翻译： 公开了一种包含黄病毒突变体的减毒黄病毒活疫苗，其特征在于黄病毒突变体在衣壳蛋白中具有至少大于4个连续氨基酸的缺失，其中羧基末端疏水区不受缺失影响。
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公开(公告)号：US09801897B2
公开(公告)日：2017-10-31
申请号：US13808085
申请日：2011-07-06
申请人： Andrew Geall , Katrin Ramsauer , Gillis Otten , Christian Mandl
发明人： Andrew Geall , Katrin Ramsauer , Gillis Otten , Christian Mandl
IPC分类号： A61K31/7088 , A61K39/00 , A61K39/12
CPC分类号： A61K31/7088 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/55555 , C12N2760/18522 , C12N2760/18534 , C12N2770/36143
摘要： RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.
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