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17 条记录 (耗时 0.02 秒)

    Method for the preparation of 1,3-disubstituted 4,5-cis-dicarboxy-2-imidazolidones
    3.
    发明授权
    Method for the preparation of 1,3-disubstituted 4,5-cis-dicarboxy-2-imidazolidones 失效
    制备1,3-二取代的4,5-顺 - 二羧基-2-咪唑啉酮的方法

    公开(公告)号：US4659837A

    公开(公告)日：1987-04-21

    申请号：US450286

    申请日：1982-12-16

    申请人： Walter Trautmann ,  Friedrich Vogel

    发明人： Walter Trautmann ,  Friedrich Vogel

    IPC分类号： C07D233/32

    CPC分类号： C07D233/32

    摘要： A process for the preparation of 1,3-disubstituted 4,5-cis-dicarboxy-2-imidazolidones useful as intermediates in the preparation of Vitamin H (biotin), said intermediates have the general formula ##STR1## in which R is an aliphatic hydrocarbon radical having 1 to 8 carbon atoms, an aralkyl radical or an aromatic hydrocarbon radical, preferably an allyl radical or a benzyl radical, comprising reacting a defined diaminosuccinic acid with phosgene in the presence of an alkali metal hydroxide.

    摘要翻译： 用作制备维生素H（生物素）的中间体的1,3-二取代的4,5-顺 - 二羧基-2-咪唑烷酮的制备方法，所述中间体具有通式“IMAGE”，其中R是脂族 包括具有1-8个碳原子的烃基，芳烷基或芳族烃基，优选烯丙基或苄基，包括在碱金属氢氧化物存在下使限定的二氨基琥珀酸与光气反应。

    Magnesium chloride or phosphonium halide derivatives of 3,7,11-trimethyl-dodeca-2,6(10)-diene(triene)-1-ol
    5.
    发明授权
    Magnesium chloride or phosphonium halide derivatives of 3,7,11-trimethyl-dodeca-2,6(10)-diene(triene)-1-ol 失效
    3,7,11-三甲基 - 十二烷-2,6（10） - 二烯（三烯）-1-醇的氯化镁或卤化鏻衍生物

    公开(公告)号：US4595783A

    公开(公告)日：1986-06-17

    申请号：US646271

    申请日：1984-08-31

    申请人： Friedrich Vogel ,  Joachim Paust ,  Axel Nuerrenbach

    发明人： Friedrich Vogel ,  Joachim Paust ,  Axel Nuerrenbach

    IPC分类号： C07C17/16 ,  C07D311/72 ,  C07F3/02 ,  C07F9/143 ,  C07F9/54

    CPC分类号： C07F9/5428 ,  C07C17/16 ,  C07D311/72 ,  C07F3/02 ,  C07F9/143

    摘要： The invention relates to intermediate compounds having the general formula I ##STR1## in which R.sup.1 is H, an alkyl, arylalkyl or an aliphatic acyl radical, preferably a benzyl or acetyl group and wherein X and Y together span an additional bond between the X and Y carrying C atoms (Ia) or in which Y is OH and X is H (Ib) and in which the dotted line can represent an additional bond particularly[2R,1'Z,3'E,7'E]-6-benzyloxy-2,5,7,8-tetramethyl-2-(4',8',12'-trimethyl-trideca-1',3',7'-trien-1'-yl)chroman and6-benzyloxy-2,5,7,8-tetramethyl-2-(1'-hydroxy-4',8',12'-trimethyl-trideca-3',7'-diene-1'-yl)chroman, as well as compounds and methods of preparing compounds having the general formula II ##STR2## in which Z is one of the groups ##STR3## wherein R.sup.2 is an alkyl group with 1 to 4 carbon atoms preferably CH.sub.3 or C.sub.2 H.sub.5particularly (3,7,11-trimethyl-trideca-2,6,10-trien-1-yl)triphenylphosphonium chloride and (3,7,11-trimethyl-trideca-2,6,10-trien-1-yl) phosphoric acid dimethylester as well as methods for the preparation of (2R,4'RS,8'Rs)-.alpha.-tocopherol and (all-rac)-.alpha.-tocopherol via the new intermediate product.

    摘要翻译： 本发明涉及具有通式I（I）的中间体化合物，其中R 1为H，烷基，芳烷基或脂族酰基，优选苄基或乙酰基，并且其中X和Y一起跨越 X和Y携带C原子（Ia）或其中Y是OH，X是H（Ib），其中虚线可以代表额外的键，特别是[2R，1'Z，3'E，7'E] -6-苄氧基-2,5,7,8-四甲基-2-（4'，8'，12'-三甲基十三碳烯-1'，3'，7'-三烯-1'-基）苯并二氢吡喃酮和 6-苄氧基-2,5,7,8-四甲基-2-（1'-羟基-4'，8'，12'-三甲基 - 三环-10a-3'，7'-二烯-1'-基）苯并二氢吡喃 ，以及制备具有通式II（II）的化合物的化合物和方法，其中Z是组ClMg之一; BrMg; （IIa）（IIc）（IIc）其中R2是具有1至4个碳原子的烷基，优选为CH3或C2H5（3,7,11-三甲基 - 十三烷-2,6,10-三烯 （3,7,11-三甲基 - 十三碳-2,6,10-三烯-1-基）磷酸二甲酯以及制备（2R，4'RS，8 'Rs） - α-生育酚和（全消旋） - α-生育酚通过新的中间产物。

    Chroman derivatives and their preparation
    6.
    发明授权
    Chroman derivatives and their preparation 失效
    色原衍生物及其制备

    公开(公告)号：US4515975A

    公开(公告)日：1985-05-07

    申请号：US439625

    申请日：1982-11-04

    申请人： Friedrich Vogel ,  Joachim Paust

    发明人： Friedrich Vogel ,  Joachim Paust

    IPC分类号： C07D311/22 ,  C07D311/58 ,  C07D311/70 ,  C07D311/72

    CPC分类号： C07D311/58 ,  C07D311/22 ,  C07D311/70 ,  Y02P20/55

    摘要： Chroman derivatives of the general formula I ##STR1## where A--B is --CH.sub.2 --CH.sub.2 --(Ia), --CH.dbd.CH--(Ib), --CHOH--CH.sub.2 --(Ic) or --CO--CH.sub.2 --(Id), R.sup.1 is --CH.sub.2 --O--R' or ##STR2## where R' is C.sub.1 -C.sub.4 -alkyl or arylmethyl and R" and R'" are each C.sub.1 -C.sub.4 -alkyl, which can also be bonded to form a five-membered or six-membered cyclic acetal, R.sup.2 is C.sub.1 -C.sub.4 -alkyl and R.sup.3 is H or a protective group.

    摘要翻译： 其中AB是-CH 2 -CH 2 - （Ia），-CH = CH-（Ib），-CHOH-CH 2 - （Ic）或-CO-CH 2 - （Id）的通式I的色原衍生物 R 1是-CH 2 -OR'或其中R'是C 1 -C 4 - 烷基或芳基甲基，R“和R”'各自是C 1 -C 4 - 烷基，其也可键合形成五元 或六元环缩醛，R2为C1-C4-烷基，R3为H或保护基。

    Cooling mat comprising expandable elements for cooling a body or body part for medical or performance-enhancing purposes (COOL APP)
    7.
    发明授权
    Cooling mat comprising expandable elements for cooling a body or body part for medical or performance-enhancing purposes (COOL APP) 有权

    公开(公告)号：US10675177B2

    公开(公告)日：2020-06-09

    申请号：US15115817

    申请日：2015-01-26

    申请人： Friedrich Vogel ,  Jakob Vogel ,  Rudolf Faworka

    发明人： Friedrich Vogel ,  Jakob Vogel ,  Rudolf Faworka

    IPC分类号： A61F7/10 ,  F25D3/08 ,  A61F7/00

    摘要： Disclosed is a device for cooling a body or body part for medical or performance-enhancing purposes, said device consisting of one or more cooling elements (11), said cooling element (11) being provided with a cover (1) that is filled with meltable cooling solid (2). The disclosed device is characterized in that an additional apparatus for displacing the already melted portion (8) of the cooling solid (2) from the contact surface (7) to the body is provided inside the cover (1), the expandable member (4, 6) being preferably designed in the form of a filled member (4) of a spring element (6) or of a foamed article. Also disclosed is an additional device which is characterized in that a layer (16) of thermochromic material indicates when a threshold temperature is exceeded, said layer (16) being applied to the bottom side of the expandable member and thus being pressed against the remaining solid portion of the cooling solid, the cover (1) being transparent in this case.

    Cooling Mat Comprising Expandable Elements for Cooling a Body or Body Part for Medical or Performance-Enhancing Purposes (COOL APP)
    8.
    发明申请
    Cooling Mat Comprising Expandable Elements for Cooling a Body or Body Part for Medical or Performance-Enhancing Purposes (COOL APP) 审中-公开
    包括用于冷却用于医疗或性能增强目的的身体或身体部位的可扩展元件的冷却垫（COOL APP）

    公开(公告)号：US20170007444A1

    公开(公告)日：2017-01-12

    申请号：US15115817

    申请日：2015-01-26

    申请人： Friedrich Vogel ,  Jakob Vogel ,  Rudolf Faworka

    发明人： Friedrich Vogel ,  Jakob Vogel ,  Rudolf Faworka

    IPC分类号： A61F7/10 ,  F25D3/08

    摘要： Disclosed is a device for cooling a body or body part for medical or performance-enhancing purposes, said device consisting of one or more cooling elements (11), said cooling element (11) being provided with a cover (1) that is filled with meltable cooling solid (2). The disclosed device is characterized in that an additional apparatus for displacing the already melted portion (8) of the cooling solid (2) from the contact surface (7) to the body is provided inside the cover (1), the expandable member (4, 6) being preferably designed in the form of a filled member (4) of a spring element (6) or of a foamed article. Also disclosed is an additional device which is characterized in that a layer (16) of thermochromic material indicates when a threshold temperature is exceeded, said layer (16) being applied to the bottom side of the expandable member and thus being pressed against the remaining solid portion of the cooling solid, the cover (1) being transparent in this case.

    摘要翻译： 公开了一种用于冷却用于医疗或性能增强目的的身体或身体部分的装置，所述装置由一个或多个冷却元件（11）组成，所述冷却元件（11）设置有盖（1），其被填充 可熔融冷却固体（2）。 所公开的装置的特征在于，用于将冷却固体（2）的已经熔化的部分（8）从接触表面（7）移位到主体的附加装置设置在盖（1）内部，可膨胀构件（4） ，6）优选地设计成弹簧元件（6）或泡沫制品的填充构件（4）的形式。 还公开了一种附加装置，其特征在于，热致变色材料层（16）指示何时超过阈值温度，所述层（16）被施加到可膨胀构件的底侧，因此被压靠在剩余的固体 在这种情况下，盖（1）是透明的。