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57 条记录 (耗时 0.025 秒)

    Production of alkyl phosphites
    4.
    发明授权
    Production of alkyl phosphites 失效
    亚磷酸烷基酯的生产

    公开(公告)号：US5344951A

    公开(公告)日：1994-09-06

    申请号：US31838

    申请日：1993-03-16

    申请人： Abbas Kadkhodayan

    发明人： Abbas Kadkhodayan

    IPC分类号： C07F9/141 ,  C07F9/142 ,  C07F9/143

    CPC分类号： C07F9/143 ,  C07F9/142

    摘要： This invention relates to an improved process for producing diesters of phosphorous acid. The process comprises (a) reacting phosphorous acid with monohydric alcohol in a petroleum distillate solvent while maintaining a reaction mass temperature within the range of from about 130.degree. to about 138.degree. C., and (b) refluxing the reaction mass during the reaction, wherein the phosphorous acid contains about 20 up to about 35 wt. % water, the molar ratio of alcohol to phosphorous acid used is within the range of from about 2.0:1 to about 4.0:1, and water is removed from the reaction mass essentially as it is formed during steps (b) and (c).

    摘要翻译： 本发明涉及一种生产亚磷酸二酯的改进方法。 该方法包括（a）在石油馏出物溶剂中使亚磷酸与一元醇反应，同时保持反应物质温度在约130℃至约138℃的范围内，和（b）在反应期间回流反应物质， 其中所述亚磷酸含有约20至约35wt。 ％的水，所使用的醇与亚磷酸的摩尔比在约2.0:1至约4.0:1的范围内，并且基本上在步骤（b）和（c）中形成的水​​从反应物质中除去， 。

    Polymer-bound phosphitylating reagents for the synthesis of organophosphorus compounds
    9.
    发明授权
    Polymer-bound phosphitylating reagents for the synthesis of organophosphorus compounds 失效
    用于合成有机磷化合物的聚合物结合的磷酸化试剂

    公开(公告)号：US08193384B2

    公开(公告)日：2012-06-05

    申请号：US11972254

    申请日：2008-01-10

    申请人： Keykavous Parang ,  Yousef Ahamdibeni

    发明人： Keykavous Parang ,  Yousef Ahamdibeni

    IPC分类号： C07F9/48 ,  C07F9/22 ,  C07F9/24 ,  C07F9/26 ,  C07F9/141 ,  C07F9/142 ,  C07F9/143 ,  C07F9/144 ,  C07F9/145 ,  C07F9/146

    CPC分类号： C07H21/02

    摘要： The synthesis and biochemical utility of modified oligonucleotides containing diphosphodiester internucleotide linkages. The synthesis of these compounds was carried out using diphosphitylating reagents. Oligonucleotides containing diphosphate diester bridges wherein said oligonucleotides are synthesized via a solid-phase synthesis strategy to form modified oligonucleotides. Diphosphitylating, triphosphitylating, tetraphosphitylating, β-triphosphitylating, bifunctional diphosphitylating, bifunctional triphosphitylating, and bifunctional tetraphosphitylating reagents wherein, the phosphorus atoms are linked together through oxygen, sulfur, amino, or methylene groups and/or are substituted with chlorine, diisopropylamine and cyanoethoxy groups.

    摘要翻译： 含有二磷酸二酯核苷酸键的修饰寡核苷酸的合成和生物化学实用性。 这些化合物的合成使用二磷酸化试剂进行。 含有二磷酸二酯桥的寡核苷酸，其中所述寡核苷酸通过固相合成策略合成以形成修饰的寡核苷酸。 双磷化，三磷酸化，四磷酸化，三磷酸化，双官能二磷酸化，双功能三磷酸化，双功能四磷酸化试剂，其中磷原子通过氧，硫，氨基或亚甲基连接在一起，和/或被氯，二异丙胺和氰基乙氧基 团体

    Non-nucleotide phosphorus ester oligomers
    10.
    发明授权
    Non-nucleotide phosphorus ester oligomers 失效
    非核苷酸磷酯低聚物

    公开(公告)号：US6008398A

    公开(公告)日：1999-12-28

    申请号：US595264

    申请日：1996-02-01

    申请人： Robert Gerard Gentles ,  Alan F. Cook ,  Morris Jonathan Rudolph ,  Reza Fathi

    发明人： Robert Gerard Gentles ,  Alan F. Cook ,  Morris Jonathan Rudolph ,  Reza Fathi

    IPC分类号： C07B59/00 ,  C07B61/00 ,  C07D233/60 ,  C07F9/141 ,  C07F9/143 ,  C07F9/144 ,  C07F9/145 ,  C07F9/24 ,  C07F9/572 ,  C07F9/58 ,  C07F9/6506 ,  C07F9/6509 ,  C07F9/6539 ,  C07F9/655 ,  C07F9/6561 ,  C07F9/6574 ,  C07F9/6578 ,  C07F9/40

    CPC分类号： C07F9/6578 ,  C07B59/004 ,  C07F9/1411 ,  C07F9/1414 ,  C07F9/143 ,  C07F9/144 ,  C07F9/145 ,  C07F9/2408 ,  C07F9/2416 ,  C07F9/242 ,  C07F9/5728 ,  C07F9/582 ,  C07F9/588 ,  C07F9/65062 ,  C07F9/650958 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/6561 ,  C07F9/65616 ,  C40B40/00 ,  Y02P20/55

    摘要： A phosphorus ester oligomer having the structure: wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substituted or unsubstituted arylamino and aminoalkyl; B.sub.1 and B.sub.2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labeling group, a protecting group, a phosphoramidate or a phosphomonoester; R.sub.1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R.sub.1 is independently selected from the group consisting of (i) a non-vicinal diol attached to a hydrogen bond donor functionality; (ii) a hydrogen bond acceptor selected from an ether; (iii) a non-vicinal diol attached to a hydrophobic functionality or a vicinal diol attached to an aliphatic or alicyclic hydrophobic functionality (iv) a diol attached to a ring substituted anionic functionality and (v) a cationic moiety attached to a non-vicinal or alicyclic diol, any of which can further include a detectable label, and n is at least two. Preferred R.sub.1 moieties include condensation products of alicyclic diols and polycyclic diols; also the non-nucleotide monomers thereof, and the use of the oligomers as selective target-binding compounds.

    摘要翻译： 具有以下结构的磷酯低聚物：其中A可以在每个单体单元中相同或不同，并且各自独立地选自氧，硫，低级烷基，取代或未取代的烷基氨基，取代或未取代的芳基氨基和氨基烷基; B1和B2可以相同或不同，各自独立地选自氢，低级烷基，标记基团，保护基，氨基磷酸酯或磷酸酯酯; R 1可以在每个单体单元中相同或不同，并且在至少一个非核苷酸单体单元中，R 1独立地选自（i）与氢键供体官能团连接的非连接二醇; （ii）选自醚的氢键受体; （iii）连接到疏水官能团的非连位二醇或连接到脂族或脂环族疏水官能团的连位二醇（iv）连接到环取代的阴离子官能团上的二醇和（v）连接到非邻位的阳离子部分 或脂环族二醇，其中任何一种可进一步包括可检测标记，并且n为至少两个。 优选的R1部分包括脂环族二醇和多环二醇的缩合产物; 也是其非核苷酸单体，以及低聚物作为选择性靶结合化合物的用途。