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公开(公告)号：US5871550A
公开(公告)日：1999-02-16
申请号：US924440
申请日：1997-08-26
CPC分类号： C11D3/38645 , A23K10/14
摘要： A mutant cellulase obtainable from Thermomonospora spp is provided which differs from a precursor cellulase in that it has been genetically engineered to introduce a substitution, deletion or addition of an amino acid residue to said precursor cellulase which provided improved activity in a detergent. Preferably, the substitution is at a residue corresponding to T140 in Thermomonospora fusca.
摘要翻译： 提供了可从热带菌属（Thermomonospora spp）获得的突变纤维素酶，其与前体纤维素酶不同，因为其已被遗传工程化以向所述前体纤维素酶中引入氨基酸残基的取代，缺失或添加，其提供了改善的洗涤剂活性。 优选地，取代是在热带孢霉菌中相当于T140的残基。
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公开(公告)号：US20120014885A1
公开(公告)日：2012-01-19
申请号：US11919717
申请日：2006-04-25
申请人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita Van Kimmenade , Gudrun Vogtentanz
发明人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita Van Kimmenade , Gudrun Vogtentanz
IPC分类号： A61K8/64 , A61Q17/04 , A61Q5/00 , A61Q1/02 , A61Q19/10 , A61Q1/10 , A61K38/08 , A61K38/16 , A61Q7/02 , C07K19/00 , A61Q15/00 , A61Q1/06
CPC分类号： A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
摘要： The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments, the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. In alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
摘要翻译： 本发明提供用于治疗各种疾病和病症的肽和负载肽。 在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。 在一些实施方案中，本发明提供用于皮肤和/或头发护理以及化妆品组合物的组合物。 在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白包含BBI。
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3.发明授权Compositions comprising bowman-birk protease inhibitors and variants thereof 有权包含bowman-birk蛋白酶抑制剂及其变体的组合物公开(公告)号：US07696173B2
公开(公告)日：2010-04-13
申请号：US12172921
申请日：2008-07-14
申请人： Katherine Collier , Grant Ganshaw , Hans De Nobel , Scott D. Power , Anita Van Kimmenade , Marc Kolkman , Jeffrey Miller , Brian Schmidt , Gudrun Vogtentanz , David Estell
发明人： Katherine Collier , Grant Ganshaw , Hans De Nobel , Scott D. Power , Anita Van Kimmenade , Marc Kolkman , Jeffrey Miller , Brian Schmidt , Gudrun Vogtentanz , David Estell
IPC分类号： A61K38/16
CPC分类号： C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
摘要： The present invention provides compositions and methods related to expression of protease inhibitors and variants thereof in bacterial species. The present invention further provides fusion nucleic acids, vectors, fusion polypeptides, and processes for obtaining the protease inhibitors.
摘要翻译： 本发明提供了与细菌种中的蛋白酶抑制剂及其变体的表达相关的组合物和方法。 本发明进一步提供融合核酸，载体，融合多肽以及获得蛋白酶抑制剂的方法。
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4.发明申请COMPOSITIONS COMPRISING BOWMAN-BIRK PROTEASE INHIBITORS AND VARIANTS THEREOF 有权包含BAMMAN-BIRK蛋白酶抑制剂及其变体的组合物公开(公告)号：US20090111160A1
公开(公告)日：2009-04-30
申请号：US12172921
申请日：2008-07-14
申请人： Katherine Collier , Grant Ganshaw , Hans De Nobel , Scott D. Power , Anita Van Kimmenade , Marc Kolkman , Jeffrey Miller , Brian Schmidt , Gudrun Vogtentanz , David Estell
发明人： Katherine Collier , Grant Ganshaw , Hans De Nobel , Scott D. Power , Anita Van Kimmenade , Marc Kolkman , Jeffrey Miller , Brian Schmidt , Gudrun Vogtentanz , David Estell
CPC分类号： C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
摘要： The present invention provides compositions and methods related to expression of protease inhibitors and variants thereof in bacterial species. The present invention further provides fusion nucleic acids, vectors, fusion polypeptides, and processes for obtaining the protease inhibitors.
摘要翻译： 本发明提供了与细菌种中的蛋白酶抑制剂及其变体的表达相关的组合物和方法。 本发明进一步提供融合核酸，载体，融合多肽以及获得蛋白酶抑制剂的方法。
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5.发明授权Bacterial expression of bowman-birk protease inhibitors and variants thereof 有权Bowman-birk蛋白酶抑制剂及其变体的细菌表达公开(公告)号：US07413877B2
公开(公告)日：2008-08-19
申请号：US10984514
申请日：2004-11-08
申请人： Katherine Collier , Grant Ganshaw , Hans De Nobel , Scott D. Power , Anita Van Kimmenade , Marc Kolkman , Jeffrey Miller , Brian Schmidt , Gudrun Vogtentanz , David Estell
发明人： Katherine Collier , Grant Ganshaw , Hans De Nobel , Scott D. Power , Anita Van Kimmenade , Marc Kolkman , Jeffrey Miller , Brian Schmidt , Gudrun Vogtentanz , David Estell
CPC分类号： C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
摘要： The present invention provides compositions and methods related to the expression of Bowman-Birk protease inhibitors and variants thereof in bacterial species. The present invention further provides fusion nucleic acids, vectors, fusion polypeptides, and processes for obtaining the Bowman-Birk protease inhibitors.
摘要翻译： 本发明提供了与细菌种中Bowman-Birk蛋白酶抑制剂及其变体的表达相关的组合物和方法。 本发明还提供了融合核酸，载体，融合多肽以及获得Bowman-Birk蛋白酶抑制剂的方法。
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公开(公告)号：US08048412B2
公开(公告)日：2011-11-01
申请号：US12369135
申请日：2009-02-11
申请人： Anita Van Kimmenade , Piet Van Solingen , Jian Yao
发明人： Anita Van Kimmenade , Piet Van Solingen , Jian Yao
CPC分类号： C11D3/48 , C11D3/38 , C11D3/38636 , C12N9/2462
摘要： The invention provides fungal polypeptides from Trichoderma reesei that possess anti-microbial activity, polynucleotides encoding the polypeptides, compositions comprising the polypeptides and polynucleotides, and methods of use, thereof.
摘要翻译： 本发明提供了具有抗微生物活性的里氏木霉真菌多肽，编码多肽的多核苷酸，包含多肽和多核苷酸的组合物及其使用方法。
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7.发明申请USE AND PRODUCTION OF NEUTRAL METALLOPROTEASES IN A SERINE PROTEASE-FREE BACKGROUND 审中-公开在丝氨酸蛋白酶免费背景下使用和生产中性金属蛋白酶公开(公告)号：US20110104786A1
公开(公告)日：2011-05-05
申请号：US12681613
申请日：2008-10-06
申请人： Anita Van Kimmenade , Edwin Lee , Andrew Shaw , Louise Wallace
发明人： Anita Van Kimmenade , Edwin Lee , Andrew Shaw , Louise Wallace
CPC分类号： C12N9/54 , C12Y304/24028
摘要： The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme in the relative absence of serine protease enzyme contaminants. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and composi-tions comprising Bacillus strains engineered to be deficient in multiple serine proteases, and their use in production of recombinant neutral metalloprotease(s).
摘要翻译： 本发明提供了相对不存在丝氨酸蛋白酶污染物的包含至少一种中性金属蛋白酶的方法和组合物。 在一些实施方案中，中性金属蛋白酶可用于清洁和其它应用。 在一些特别优选的实施方案中，本发明提供包含工程改造为缺陷多种丝氨酸蛋白酶的芽孢杆菌菌株的方法和组合，以及它们在重组中性金属蛋白酶的生产中的用途。
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公开(公告)号：US20090232788A1
公开(公告)日：2009-09-17
申请号：US12369135
申请日：2009-02-11
申请人： Anita Van Kimmenade , Piet Van Solingen , Jian Yao
发明人： Anita Van Kimmenade , Piet Van Solingen , Jian Yao
IPC分类号： A61K38/46 , A23J3/20 , C12P21/06 , C12N9/14 , C12N1/15 , C12N15/63 , C07H21/04 , D06L1/00 , C12S11/00
CPC分类号： C11D3/48 , C11D3/38 , C11D3/38636 , C12N9/2462
摘要： The invention provides fungal polypeptides from Trichoderma reesei that possess anti-microbial activity, polynucleotides encoding the polypeptides, compositions comprising the polypeptides and polynucleotides, and methods of use, thereof.
摘要翻译： 本发明提供了具有抗微生物活性的里氏木霉真菌多肽，编码多肽的多核苷酸，包含多肽和多核苷酸的组合物及其使用方法。
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公开(公告)号：US20070172921A1
公开(公告)日：2007-07-26
申请号：US11725899
申请日：2007-03-19
CPC分类号： C07K14/32
摘要： The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods for producing proteins in such host cells, such as members of the genus Bacillus. More specifically, the present invention relates to the expression, production and secretion of a polypeptide of interest and to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention provides for the enhanced expression of a selected polypeptide by a microorganism.
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公开(公告)号：US07544488B2
公开(公告)日：2009-06-09
申请号：US11725836
申请日：2007-03-19
IPC分类号： C12P21/06
CPC分类号： C07K14/32
摘要： The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods for producing proteins in such host cells, such as members of the genus Bacillus. More specifically, the present invention relates to the expression, production and secretion of a polypeptide of interest and to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention provides for the enhanced expression of a selected polypeptide by a microorganism.
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