4,4'-bis-(.beta.-hydroxyethylsulfonyl)-biphenyl and its esters
    2.
    发明授权
    4,4'-bis-(.beta.-hydroxyethylsulfonyl)-biphenyl and its esters 失效
    4,4'-双 - (β-羟乙基磺酰基) - 联苯及其酯

    公开(公告)号:US4659856A

    公开(公告)日:1987-04-21

    申请号:US775138

    申请日:1985-09-12

    摘要: Compounds of the general formula (1) ##STR1## in which the Zs, preferably identical to each other, each denote a hydroxy group or a sulfato, thiosulfato or phosphato group. They can be prepared by first converting biphenyl by sulfochlorination into biphenyl-4,4'-disulfochloride, then reducing the latter with an alkali metal or alkaline earth metal sulfite or hydrogensulfite to sulfinic acid, and in turn reacting the latter with ethylene oxide to give 4,4'-bis-(.beta.-hydroxyethylsulfonyl)-biphenyl, which can be esterified in conventional manner. They are used for modifying and improving the physical and coloristic properties of materials made of natural and/or synthetic polyamide fibers and/or polyurethane fibers and as auxiliaries in dyeing processes for such fiber materials.

    摘要翻译: 其中Z,优选彼此相同的通式(1)的化合物(1)各自表示羟基或硫酸根,硫代硫酸根或磷酸根。 它们可以通过首先通过磺基氯化将联苯转化为联苯-4,4'-二磺酰氯,然后用碱金属或碱土金属亚硫酸盐或亚硫酸氢盐将其还原成亚磺酸,然后将其与环氧乙烷反应,得到 4,4'-双 - (β-羟乙基磺酰基) - 联苯,其可以常规方式酯化。 它们用于改善和改善由天然和/或合成聚酰胺纤维和/或聚氨酯纤维制成的材料的物理和色彩特性,并用作这种纤维材料的染色工艺中的助剂。

    Method for the production of statins
    6.
    发明申请
    Method for the production of statins 审中-公开
    他汀类药物的生产方法

    公开(公告)号:US20070093660A1

    公开(公告)日:2007-04-26

    申请号:US10578706

    申请日:2004-11-09

    IPC分类号: C07D405/02 C07D239/02

    CPC分类号: C07D309/30 Y02P20/55

    摘要: According to the invention, a process for the preparation of a statin is provided, comprising the following steps: a) preparation of a compound of the formula II in which S1 denotes a hydrogen atom or a hydroxylprotective group, S2 and S3, independently of one another, denote hydroxylprotective groups and R1 represents a hydrogen atom or a carboxylprotective group, by stereoselective hydrogenation of a compound of the formula III to give a compound of the formula II-a and optionally introduction of a hydroxylprotective group and b) lactonization of the compound of the formula II to give a compound of the formula I-a

    摘要翻译: 根据本发明,提供了一种制备他汀类药物的方法,包括以下步骤:a)制备式II化合物,其中S 1至O 1表示氢原子或羟基保护基团 S 2和S 3彼此独立地表示羟基保护基,R 1表示氢原子或羧基保护基,通过立体选择性 氢化式III化合物,得到式II-a的化合物和任选地引入羟基保护基团,和b)式II化合物的内酯化,得到式Ia化合物