公开(公告)号：US06713018B2

公开(公告)日：2004-03-30

申请号：US09836537

申请日：2001-04-18

申请人： Fumio Sugaya ,  Yoichi Endo ,  Nobuaki Tokiwa ,  Akihiro Komatsu ,  Yoshihiro Seto

发明人： Fumio Sugaya ,  Yoichi Endo ,  Nobuaki Tokiwa ,  Akihiro Komatsu ,  Yoshihiro Seto

IPC分类号： G01N3122

CPC分类号： G01N33/48757 ,  G01N35/00029 ,  G01N2035/00059 ,  G01N2035/00089

摘要： A dry chemical analysis element cartridge includes a box-like cartridge casing in which a plurality of chemical analysis elements are stacked and are taken out through an element take-out port formed at one end of the cartridge casing. The inner dimension of the cartridge casing in the direction of the stack of the chemical analysis elements is smaller than the longitudinal and transverse dimensions of each of the chemical analysis elements.

摘要翻译： 干化学分析元件盒包括盒状盒壳体，其中堆叠多个化学分析元件，并且通过形成在盒壳体一端的元件取出口取出。 药筒外壳在化学分析元件的堆叠方向上的内部尺寸小于每个化学分析元件的纵向和横向尺寸。

公开(公告)号：US06642058B2

公开(公告)日：2003-11-04

申请号：US09853751

申请日：2001-05-14

申请人： Fumio Sugaya ,  Yoichi Endo ,  Nobuaki Tokiwa ,  Akihiro Komatsu ,  Yoshihiro Seto

发明人： Fumio Sugaya ,  Yoichi Endo ,  Nobuaki Tokiwa ,  Akihiro Komatsu ,  Yoshihiro Seto

IPC分类号： G01N3348

CPC分类号： G01N21/5907

摘要： An analysis method using a dry chemical analysis element accurately measures change in optical density indicating the composition of a liquid sample without requiring accurate control of the amount and position of the liquid sample dripped on the dry chemical analysis element. A one-dimensional or two-dimensional optical reading apparatus measures one-dimensional or two-dimensional distribution of degree of color reaction for a reacted portion of the dry chemical analysis element. Concurrently, the one-dimensional or two-dimensional optical reading apparatus measures a length or a spread area of the reacted portion. Physical density or activity of a target component contained in the liquid sample is determined based on an integrated value of the degree of the color reaction and the measured length or the spread area of the reacted portion.

摘要翻译： 使用干化学分析元件的分析方法精确地测量表示液体样品组成的光密度变化，而不需要精确控制滴在干化学分析元件上的液体样品的量和位置。 一维或二维光学读取装置测量干化学分析元件的反应部分的显色反应程度的一维或二维分布。 同时，一维或二维光学读取装置测量反应部分的长度或扩展面积。 基于颜色反应程度和反应部分的测量长度或扩展面积的积分值来确定液体样品中包含的目标组分的物理密度或活性。

公开(公告)号：US20050089445A1

公开(公告)日：2005-04-28

申请号：US10993482

申请日：2004-11-22

申请人： Fumio Sugaya ,  Akihiro Komatsu

发明人： Fumio Sugaya ,  Akihiro Komatsu

IPC分类号： G01N1/38 ,  G01N21/25 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10

CPC分类号： G01N21/253 ,  G01N1/38 ,  G01N35/025 ,  G01N2035/00079 ,  G01N2035/00089 ,  G01N2035/00108 ,  G01N2035/00376 ,  G01N2035/00752 ,  G01N2035/103 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1053 ,  G01N2035/106 ,  Y10T436/11 ,  Y10T436/111666

摘要： An incubator includes a rotating incubator rotor. The incubator rotor is provided with a plurality of element chambers which are arranged along the outer periphery of the incubator rotor and each of which accommodates a dry analysis element spotted with a sample and incubates the dry analysis element. A light measuring system has a light measuring head which measures the optical density of the dry analysis element. The light measuring system is provided with a correction system which compensates for fluctuation in the value of the optical density of the dry analysis element in each of the element chambers as measured by the light measuring head generated due to fluctuation in the distance between the light measuring head and the element chamber on the basis of a correction value which has been stored in the correction system element chamber by element chamber.

摘要翻译： 孵化器包括旋转的孵化器转子。 培养箱转子设置有沿着培养箱转子的外周布置的多个元件室，每个元件室容纳用样品点样的干燥分析元件并孵育干燥分析元件。 光测量系统具有测量干分析元件的光密度的光测量头。 光测量系统设置有校正系统，其补偿由每个元件室中的干燥分析元件的光密度的值的波动，由通过光测量之间的距离的波动而产生的光测量头测量 基于已经通过元件室存储在校正系统元件室中的校正值的头和元件室。

公开(公告)号：US07435382B2

公开(公告)日：2008-10-14

申请号：US10993482

申请日：2004-11-22

申请人： Fumio Sugaya ,  Akihiro Komatsu

发明人： Fumio Sugaya ,  Akihiro Komatsu

IPC分类号： G01N35/00

CPC分类号： G01N21/253 ,  G01N1/38 ,  G01N35/025 ,  G01N2035/00079 ,  G01N2035/00089 ,  G01N2035/00108 ,  G01N2035/00376 ,  G01N2035/00752 ,  G01N2035/103 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1053 ,  G01N2035/106 ,  Y10T436/11 ,  Y10T436/111666

摘要： An incubator includes a rotating incubator rotor. The incubator rotor is provided with a plurality of element chambers which are arranged along the outer periphery of the incubator rotor and each of which accommodates a dry analysis element spotted with a sample and incubates the dry analysis element. A light measuring system has a light measuring head which measures the optical density of the dry analysis element. The light measuring system is provided with a correction system which compensates for fluctuation in the value of the optical density of the dry analysis element in each of the element chambers as measured by the light measuring head generated due to fluctuation in the distance between the light measuring head and the element chamber on the basis of a correction value which has been stored in the correction system element chamber by element chamber.

摘要翻译： 孵化器包括旋转的孵化器转子。 培养箱转子设置有沿着培养箱转子的外周布置的多个元件室，每个元件室容纳用样品点样的干燥分析元件并孵育干燥分析元件。 光测量系统具有测量干分析元件的光密度的光测量头。 光测量系统设置有校正系统，其补偿由每个元件室中的干燥分析元件的光密度的值的波动，由通过光测量之间的距离的波动而产生的光测量头测量 基于已经通过元件室存储在校正系统元件室中的校正值的头和元件室。

公开(公告)号：US07048489B2

公开(公告)日：2006-05-23

申请号：US10459569

申请日：2003-06-12

申请人： Fumio Sugaya ,  Yoichi Endo ,  Akihiro Komatsu ,  Tomoyuki Takiue

发明人： Fumio Sugaya ,  Yoichi Endo ,  Akihiro Komatsu ,  Tomoyuki Takiue

IPC分类号： B67B7/68

CPC分类号： B65B69/0008

摘要： A slide pack container housing a plurality of piled slide packs has a cut-off portion. The cut-off portion has a width slightly larger than the width of a slide contained in each slide pack. As a sucker of a package take-out apparatus draws one of the slide packs from the slide pack container through the cut-off portion, a sealed portion of the slide pack interfering with the edge of the cut-off portion is folded inward so that the slide pack is successfully taken out. The sucker transfers the slide pack to a separated unwrapping apparatus. The sucker releases the slide pack when the front edge of the slide pack is caught between paired rollers of the unwrapping apparatus. After a cutter makes a slit on the slide pack, the paired rollers transfer only a wrapping sheet to separate the wrapping sheet from the slide wrapped therewith.

公开(公告)号：US06431813B1

公开(公告)日：2002-08-13

申请号：US09810610

申请日：2001-03-19

申请人： Fumio Sugaya ,  Yoichi Endo ,  Akihiro Komatsu ,  Tomoyuki Takiue

发明人： Fumio Sugaya ,  Yoichi Endo ,  Akihiro Komatsu ,  Tomoyuki Takiue

IPC分类号： B67B768

摘要： An unwrapping apparatus unwraps a slide pack wrapped with a wrapping sheet to obtain a slide contained therein. As paired rollers forward the slide pack, a squeezing member squeezes the slide backward within an unsealed space in the slide pack to form a wide cut allowance at the front edge of the slide pack. After the slide reaches the rear end of the unsealed space, nip pressure applied to the slide pack by the paired rollers is reduced to further forward the slide pack to a predetermined position. At the predetermined position, a cutter partially cuts the cut allowance to form a slit thereon. Then, the slide pack is transferred back by the paired rollers under a raised nip pressure which is sufficient to squeeze the slide out from the slit. Accordingly, the slide will be gradually separated from the wrapping sheet.

公开(公告)号：US5660793A

公开(公告)日：1997-08-26

申请号：US459629

申请日：1995-06-02

申请人： Shunichi Seto ,  Akihiro Komatsu

发明人： Shunichi Seto ,  Akihiro Komatsu

IPC分类号： G01N35/04 ,  G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00029 ,  G01N2035/00049 ,  Y10T436/112499 ,  Y10T436/114165 ,  Y10T436/114998

摘要： A biochemical analysis system includes a depositing mechanism which deposits a sample liquid on a chemical analysis slide having a reagent layer, an incubator which incubates the chemical analysis slide with the sample liquid at a predetermined temperature for a predetermined time, a transfer mechanism which loads the slide in the incubator and removes it therefrom, and an optical density measuring system which measures the optical density of the chemical analysis slide after incubation and determines the concentration of a specific biochemical component in the sample liquid through the optical density of the chemical analysis slide. The incubator has a rotary body in which a slide discarding hole is formed at the center thereof and a plurality of slide holding portions are formed to extend from the outer peripheral surface of the rotary body toward the center of the rotary body and communicate with the slide discarding hole. The transfer mechanism inserts the chemical analysis slides into the respective slide holding portions by moving each slide toward the center of the rotary body and drops the slides into the discarding hole after measurement by moving the slides further toward the center of the rotary body.

摘要翻译： 生物化学分析系统包括沉积机构，其将样品液体沉积在具有试剂层的化学分析载玻片上，将化学分析载玻片与样品液体在预定温度下孵育预定时间的培养箱， 在培养箱中滑动并将其从其中除去，以及光学密度测量系统，其测量孵育后化学分析载玻片的光密度，并通过化学分析载玻片的光密度确定样品液体中特定生物化学成分的浓度。 培养箱具有在其中心形成有滑动废弃孔的旋转体，并且形成有多个滑动保持部，从旋转体的外周面朝向旋转体的中心延伸并与滑动体连通 丢弃孔。 传送机构通过使每个滑动件朝向旋转体的中心移动而将化学分析滑块插入到各个滑动保持部分中，并且通过将滑块朝向旋转体的中心移动而将测量后的滑块落入废弃孔中。

公开(公告)号：US5607861A

公开(公告)日：1997-03-04

申请号：US664799

申请日：1996-06-17

申请人： Akihiro Komatsu ,  Nobuaki Tokiwa ,  Yoshio Saito

发明人： Akihiro Komatsu ,  Nobuaki Tokiwa ,  Yoshio Saito

IPC分类号： G01N33/52 ,  B01L3/02 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N35/10

CPC分类号： B01L3/0262 ,  G01N35/10 ,  G01N2035/1034 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/115831 ,  Y10T436/12

摘要： A predetermined amount of a liquid sample is accommodated in a sample spotting tip, which is fitted to a bottom end of a suction nozzle for sucking the liquid sample. Thereafter, the sample spotting tip is moved down, and the bottom end of the sample spotting tip is thereby brought into contact with a dry-type frameless chemical analysis film piece. The sample spotting tip is then moved up. The pressure inside the sample spotting tip is increased, while the sample spotting tip is thus being moved up. The liquid sample is thereby discharged from the sample spotting tip onto the dry-type frameless chemical analysis film piece.

摘要翻译： 将预定量的液体样品容纳在样品点样尖端中，该样品点样尖端装配到用于吸取液体样品的吸嘴的底端。 然后，将样品点样尖端向下移动，使样品点样尖端的底端与干式无框架化学分析薄膜片接触。 然后将样品点样尖端向上移动。 样品点样尖端内的压力增加，同时样品点样尖端因此向上移动。 因此，液体样品从样品点样尖端排出到干式无框架化学分析膜片上。

公开(公告)号：US4508944A

公开(公告)日：1985-04-02

申请号：US481635

申请日：1983-04-04

申请人： Michio Yashima ,  Akihiro Komatsu ,  Masami Takanashi ,  Masashi Hirose ,  Kengo Nakayama

发明人： Michio Yashima ,  Akihiro Komatsu ,  Masami Takanashi ,  Masashi Hirose ,  Kengo Nakayama

IPC分类号： B62J6/16 ,  H01H13/72 ,  H01H9/06

CPC分类号： B62K11/14 ,  B62J6/16 ,  H01H13/72 ,  H01H2009/068

摘要： A handle switch assembly is arranged on the steering handle in the vicinity of a handle grip, and includes at least one switch comprising a plurality of first push buttons arranged on a surface of the switch housing, and a second push button arranged in a manner independent and separate from the first push buttons. Each of the first push buttons, when pushed, causes the switch to turn on and holds same in the on-state, while the second push button, when pushed, releases the switch from its on-state. The first push buttons are juxtaposed axially of the handle grip, and the second push button is spaced in a predetermined circumferential direction from a line connecting between side edges of the first push buttons facing in the same predetermined circumferential direction.

摘要翻译： 手柄开关组件设置在手柄附近的转向手柄上，并且包括至少一个开关，其包括布置在开关壳体的表面上的多个第一按钮和以独立方式布置的第二按钮 并与第一按钮分开。 当按下时，每个第一按钮使得开关在导通状态下打开并保持相同，而当按下第二按钮时，第二按钮将其从开启状态释放。 所述第一按钮在所述手柄把手的轴向并列配置，所述第二按钮沿着与所述第一按钮的侧缘相连的线与预定的圆周方向相对的预定圆周方向隔开。

公开(公告)号：US5879944A

公开(公告)日：1999-03-09

申请号：US105253

申请日：1998-06-26

申请人： Akihiro Komatsu

发明人： Akihiro Komatsu

IPC分类号： G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00029 ,  G01N2035/00059 ,  G01N2035/1034 ,  G01N35/1016 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A method of continuously spotting a liquid onto a predetermined number of members to be spotted with the liquid includes the steps of mounting a disposable spotting tip on a suction nozzle, sucking the liquid in the spotting tip in a predetermined amount larger than the predetermined number times the amount for one spotting and discharging the liquid onto the members in sequence by the amount for one spotting by introducing a predetermined discharge pressure into the spotting tip. A signal related to the vapor pressure in atmosphere is obtained and the discharge pressure is corrected according to the change in the vapor pressure inside the spotting tip after the liquid is sucked in the spotting tip so that the same amount of the liquid is discharged onto all the members.

摘要翻译： 将液体连续地点到预定数量的用液体点样的构件的方法包括以下步骤：将一次性点样尖端安装在吸嘴上，以大于预定次数的预定量吸取点样尖端中的液体 用于通过将预定的排出压力引入到点样尖端中，一次点样并将液体排出到构件上的量。 获得与大气中的蒸气压相关的信号，并且在液体被吸入点样尖端之后，根据喷射尖端内部的蒸气压的变化来校正排出压力，使得相同量的液体排出到所有 成员。