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    Microchip solution sending system
    1.
    发明授权
    Microchip solution sending system 有权

    公开(公告)号：US09952210B2

    公开(公告)日：2018-04-24

    申请号：US14116219

    申请日：2012-05-08

    申请人： Noriaki Yamamoto ,  Youichi Aoki

    发明人： Noriaki Yamamoto ,  Youichi Aoki

    IPC分类号： B01L3/00 ,  G01N33/543 ,  G01N35/10

    CPC分类号： G01N33/54373 ,  B01L3/502715 ,  B01L2200/0605 ,  B01L2300/0877 ,  B01L2400/0487 ,  G01N2035/106

    摘要： A microchip solution sending system may include a flow passage assembly that is at least provided with a fine flow passage that is provided with a detection region including a formed reaction field to which an antibody that reacts with a specific antigen is fixed; and a micro pump that is connected to the flow passage assembly and that is configured to send a specimen material solution that includes the specific antigen in a reciprocating manner. The specimen material solution that has been sent may pass through the detection region in a repetitive manner in the case in which the micro pump sends the specimen material solution in a reciprocating manner.

    Methods, devices, and systems for mixing fluids
    2.
    发明授权
    Methods, devices, and systems for mixing fluids 有权
    用于混合流体的方法，装置和系统

    公开(公告)号：US09513197B2

    公开(公告)日：2016-12-06

    申请号：US15069263

    申请日：2016-03-14

    申请人： Theranos, Inc.

    发明人： Matthew Black

    IPC分类号： G01N1/38 ,  G01N35/02 ,  G01N35/10 ,  B01F11/00 ,  B01F15/00 ,  B01L3/00

    CPC分类号： G01N35/10 ,  B01F11/0074 ,  B01F15/00876 ,  B01F2215/0037 ,  B01L3/508 ,  B01L2300/0848 ,  B01L2300/12 ,  G01N1/38 ,  G01N2001/386 ,  G01N2035/106

    摘要： Improved methods, devices, and systems for mixing fluids, including small volumes of fluid, are provided. Pressing a pipette tip against an inner surface of a mixing vessel allows pressure to be applied within the tip. Greater pressure may be built-up than would be possible without engaging the tip with the mixing vessel. Disengaging the tip allows fluid flow through the tip, providing improved fluid mixing as compared to methods lacking engagement of a pipette tip with an inner surface of a mixing vessel while applying pressure within the pipette tip.Mixing vessels having features on an inner surface that are configured to engage a pipette tip, and to occlude an orifice of a pipette tip, are provided. Sample analysis devices and systems including pipette tips and mixing vessels configured to engage each other for pressure application within the tip are provided.

    摘要翻译： 提供了具有内表面上具有配置成接合移液管末端并且封闭移液管尖端的孔的特征的混合容器。 提供了样品分析装置和系统，其包括配置成彼此接合以在尖端内施加压力的移液管尖端和混合容器。

    Incubator
    4.
    发明授权
    Incubator 失效
    孵化器

    公开(公告)号：US07435382B2

    公开(公告)日：2008-10-14

    申请号：US10993482

    申请日：2004-11-22

    申请人： Fumio Sugaya ,  Akihiro Komatsu

    发明人： Fumio Sugaya ,  Akihiro Komatsu

    IPC分类号： G01N35/00

    CPC分类号： G01N21/253 ,  G01N1/38 ,  G01N35/025 ,  G01N2035/00079 ,  G01N2035/00089 ,  G01N2035/00108 ,  G01N2035/00376 ,  G01N2035/00752 ,  G01N2035/103 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1053 ,  G01N2035/106 ,  Y10T436/11 ,  Y10T436/111666

    摘要： An incubator includes a rotating incubator rotor. The incubator rotor is provided with a plurality of element chambers which are arranged along the outer periphery of the incubator rotor and each of which accommodates a dry analysis element spotted with a sample and incubates the dry analysis element. A light measuring system has a light measuring head which measures the optical density of the dry analysis element. The light measuring system is provided with a correction system which compensates for fluctuation in the value of the optical density of the dry analysis element in each of the element chambers as measured by the light measuring head generated due to fluctuation in the distance between the light measuring head and the element chamber on the basis of a correction value which has been stored in the correction system element chamber by element chamber.

    摘要翻译： 孵化器包括旋转的孵化器转子。 培养箱转子设置有沿着培养箱转子的外周布置的多个元件室，每个元件室容纳用样品点样的干燥分析元件并孵育干燥分析元件。 光测量系统具有测量干分析元件的光密度的光测量头。 光测量系统设置有校正系统，其补偿由每个元件室中的干燥分析元件的光密度的值的波动，由通过光测量之间的距离的波动而产生的光测量头测量 基于已经通过元件室存储在校正系统元件室中的校正值的头和元件室。

    IMPROVED FLUID MIXING IN A DIAGNOSTIC ANALYZER
    6.
    发明申请
    IMPROVED FLUID MIXING IN A DIAGNOSTIC ANALYZER 审中-公开
    改进的液体混合在诊断分析仪

    公开(公告)号：US20050014284A1

    公开(公告)日：2005-01-20

    申请号：US10622258

    申请日：2003-07-18

    申请人： Merrit Jacobs ,  Ed Graham

    发明人： Merrit Jacobs ,  Ed Graham

    IPC分类号： B01F11/00 ,  G01N33/92 ,  G01N35/00 ,  G01N35/10 ,  G01N1/10

    CPC分类号： B01F11/0071 ,  B01F11/0074 ,  G01N33/92 ,  G01N35/10 ,  G01N2035/106 ,  Y10T436/25 ,  Y10T436/2575

    摘要： A method for mixing a liquid in a container in a diagnostic analyzer that includes: (a) providing a probe having a probe tip for aspirating and dispensing the liquid in the container; (b) providing the container containing one or more liquid(s) to be mixed; (c) inserting the probe into a first location of the container; (d) aspirating the one or more liquid(s) into the probe; (e) repositioning the probe or container to place the probe at a second location in the container; and (f) dispensing the one or more liquid(s) with the probe. A method of determining the amount of an analyte in a sample, includes the steps of: providing a sample containing an analyte in a container; providing a first reagent in the container; mixing the first reagent and sample as described above; optionally incubating the combined sample and reagent; optionally adding a second reagent to the container and mixing the second reagent and sample and first reagent as described above; and analyzing the sample for an analyte.

    摘要翻译： 一种用于在诊断分析仪中将容器中的液体混合的方法，包括：（a）提供具有用于吸入和分配容器中的液体的探针尖端的探针; （b）提供含有一种或多种待混合液体的容器; （c）将探针插入容器的第一位置; （d）将一种或多种液体吸入探针中; （e）重新定位探针或容器以将探针放置在容器中的第二位置; 和（f）用探针分配一种或多种液体。 确定样品中分析物的量的方法包括以下步骤：在容器中提供含有分析物的样品; 在容器中提供第一试剂; 如上所述混合第一试剂和样品; 任选地孵化组合的样品和试剂; 任选地向容器中加入第二试剂并如上所述混合第二试剂和样品和第一试剂; 并分析样品中的分析物。

    Incubator
    7.
    发明申请
    Incubator 审中-公开
    孵化器

    公开(公告)号：US20020090321A1

    公开(公告)日：2002-07-11

    申请号：US10042319

    申请日：2002-01-11

    申请人： FUJI PHOTO FILM CO., LTD.

    发明人： Fumio Sugaya ,  Akihiro Komatsu

    IPC分类号： G01N035/00

    CPC分类号： G01N21/253 ,  G01N1/38 ,  G01N35/025 ,  G01N2035/00079 ,  G01N2035/00089 ,  G01N2035/00108 ,  G01N2035/00376 ,  G01N2035/00752 ,  G01N2035/103 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1053 ,  G01N2035/106 ,  Y10T436/11 ,  Y10T436/111666

    摘要： An incubator includes a rotating incubator rotor. The incubator rotor is provided with a plurality of element chambers which are arranged along the outer periphery of the incubator rotor and each of which accommodates a dry analysis element spotted with a sample and incubates the dry analysis element. A light measuring system has a light measuring head which measures the optical density of the dry analysis element. The light measuring system is provided with a correction system which compensates for fluctuation in the value of the optical density of the dry analysis element in each of the element chambers as measured by the light measuring head generated due to fluctuation in the distance between the light measuring head and the element chamber on the basis of a correction value which has been stored in the correction system element chamber by element chamber.

    摘要翻译： 孵化器包括旋转的孵化器转子。 培养箱转子设置有沿着培养箱转子的外周布置的多个元件室，每个元件室容纳用样品点样的干燥分析元件并孵育干燥分析元件。 光测量系统具有测量干分析元件的光密度的光测量头。 光测量系统设置有校正系统，其补偿由每个元件室中的干燥分析元件的光密度的值的波动，由通过光测量之间的距离的波动而产生的光测量头测量 基于已经通过元件室存储在校正系统元件室中的校正值的头和元件室。

    Automatic cycling reaction apparatus and automatic analyzing apparatus using the same
    8.
    发明授权
    Automatic cycling reaction apparatus and automatic analyzing apparatus using the same 失效
    自动循环反应装置及使用其的自动分析装置

    公开(公告)号：US4981801A

    公开(公告)日：1991-01-01

    申请号：US734215

    申请日：1985-05-15

    申请人： Yoshiyuki Suzuki ,  Takahiko Kato

    发明人： Yoshiyuki Suzuki ,  Takahiko Kato

    IPC分类号： B01L7/00 ,  C12M1/34 ,  C12M1/40 ,  C12Q1/26 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

    CPC分类号： B01L7/52 ,  C12M21/18 ,  C12M41/36 ,  G01N35/02 ,  G01N2035/00366 ,  G01N2035/00396 ,  G01N2035/00435 ,  G01N2035/00445 ,  G01N2035/042 ,  G01N2035/106 ,  G01N35/025 ,  G01N35/1004

    摘要： An apparatus for carrying out an enzymatic cycling reaction including a turntable arranged in a reaction tank, a number of reaction vessels being arranged in the turntable along its periphery, a device for circulating an antifreeze liquid through the reaction tank, a heater for heating the antifreeze liquid, a refrigerator for cooling the antifreeze liquid and a switching valve for selectively passing the antifreeze liquid through the heater or refrigerator. Until all the samples and cycling mixture are delivered into the reaction vessels, the reaction tank is held at a very low temperature at which no enzymatic cycling reaction proceeds. Then the antifreeze liquid is heated to an enzymatic cycling reaction temperature so as to perform the enzymatic cycling reaction simultaneously for liquids contained in all the reaction vessels for a desired period. Then, the antifreeze liquid is heated to a high temperature so as to stop simultaneously the cycling reaction in all the reaction vessels.

    摘要翻译： 一种用于进行酶循环反应的装置，包括设置在反应槽中的转台，沿其周边设置在转台中的多个反应容器，用于使防冻液循环通过反应罐的装置，用于加热防冻剂的加热器 液体，用于冷却防冻液的冰箱和用于选择性地使防冻液通过加热器或冰箱的切换阀。 直到所有样品和循环混合物被输送到反应容器中，反应罐保持在没有酶循环反应进行的非常低的温度。 然后将防冻液加热至酶循环反应温度，以对所有反应容器中所含的液体同时进行酶循环反应达期望的时间。 然后，将防冻液加热到高温，以同时停止所有反应容器中的循环反应。