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    Adsorbent for immunoglobulins and complexes thereof, adsorption method, and adsorption device
    2.
    发明授权
    Adsorbent for immunoglobulins and complexes thereof, adsorption method, and adsorption device 有权
    免疫球蛋白吸附剂及其配合物，吸附方法和吸附装置

    公开(公告)号：US6133431A

    公开(公告)日：2000-10-17

    申请号：US117233

    申请日：1998-10-20

    申请人： Takamune Yasuda ,  Osamu Odawara ,  Eiji Ogino ,  Michio Nomura ,  Takahisa Nakai ,  Takashi Asahi ,  Nobutaka Tani

    发明人： Takamune Yasuda ,  Osamu Odawara ,  Eiji Ogino ,  Michio Nomura ,  Takahisa Nakai ,  Takashi Asahi ,  Nobutaka Tani

    IPC分类号： A61K35/14 ,  A61M1/36 ,  B01J20/32 ,  C07K17/00 ,  C07K17/02 ,  A61K39/00

    CPC分类号： C07K17/02 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3274 ,  B01J20/3282 ,  C07K17/00 ,  A61M1/3679 ,  A61M2202/0417

    摘要： An adsorbent that exhibits a high specificity in adsorbing immunoglobulins and/or complexes thereof, is extremely reduced in the lowering of the adsorption characteristic during sterilization or storage, is highly stable and safe, and is prepared by immobilizing on a water-insoluble support either a peptide derivative which has undergone at least one of the deletion, substitution, insertion, or addition of amino acids in a peptide having a specified amino acid sequence or an amino acid sequence, or the above peptide derivative which has undergone the addition of Lyn or Cys at the amino and/or carboxyl terminal thereof; a device for adsorption and removal made by packing the adsorbent in a vessel equipped with effluent preventing means; and a method of adsorbing and removing immunoglobulins and/or complexes thereof contained in the blood, plasma or other body fluids with the adsorbent.

    摘要翻译： PCT No.PCT / JP97 / 00161 Sec。 371日期：1998年10月20日 102（e）日期1998年10月20日PCT 1997年1月24日PCT公布。 第WO97 / 26930号公报 日期1997年7月31日在吸附免疫球蛋白和/或其复合物中显示高特异性的吸附剂在灭菌或储存期间吸附特性的降低极度降低，是高度稳定和安全的，并且通过固定在水上制备 - 不溶性支持已经在具有特定氨基酸序列或氨基酸序列的肽中经历了氨基酸的缺失，取代，插入或添加中的至少一个的肽衍生物，或上述已经经历 在其氨基和/或羧基末端添加Lyn或Cys; 用于通过将吸附剂包装在装有流出物防止装置的容器中而进行吸附和除去的装置; 以及利用吸附剂吸收和除去血液，血浆或其他体液中所含的免疫球蛋白和/或其复合物的方法。

    Adsorbent for bradykinin, method for eliminating the same by adsorption, and adsorber
    3.
    发明授权
    Adsorbent for bradykinin, method for eliminating the same by adsorption, and adsorber 失效
    用于缓激肽的吸附剂，通过吸附除去其的方法和吸附剂

    公开(公告)号：US06387362B1

    公开(公告)日：2002-05-14

    申请号：US09043537

    申请日：1998-08-14

    申请人： Fumiyasu Hirai ,  Nobutaka Tani ,  Takamune Yasuda ,  Takashi Asahi

    发明人： Fumiyasu Hirai ,  Nobutaka Tani ,  Takamune Yasuda ,  Takashi Asahi

    IPC分类号： A61K31795

    CPC分类号： B01J20/26 ,  A61M1/3679

    摘要： An adsorbent or bradykinin comprising styrene-divinylbenzene copolymer having sulfonic acid groups and a method for adsorbing and removing bradykinin comprising contacting the adsorbent with a fluid containing bradykinin are provided. An adsorber for adsorbing bradykinin in which the adsorbent is charged in a vessel having an inlet and an outlet for a fluid is also provided.

    摘要翻译： 提供了包含具有磺酸基的苯乙烯 - 二乙烯基苯共聚物的吸附剂或缓激肽以及吸收和去除缓激肽的方法，包括使吸附剂与含有缓激肽的流体接触。 还提供了用于吸附缓冲激肽的吸附剂，其中将吸附剂装入具有流体入口和出口的容器中。

    Process for adsorbing and removing tumor necrosis factor-.alpha.
    6.
    发明授权
    Process for adsorbing and removing tumor necrosis factor-.alpha. 有权
    吸附和去除肿瘤坏死因子-α的方法

    公开(公告)号：US06127528A

    公开(公告)日：2000-10-03

    申请号：US283964

    申请日：1999-04-02

    申请人： Fumiyasu Hirai ,  Nobutaka Tani ,  Takashi Asahi

    发明人： Fumiyasu Hirai ,  Nobutaka Tani ,  Takashi Asahi

    IPC分类号： C07K14/525 ,  C07K1/22 ,  A61K38/19 ,  C07K1/14 ,  C07K14/00

    CPC分类号： C07K14/525 ,  Y10S930/144

    摘要： The present invention relates to an adsorbent being capable of efficiently removing tumor necrosis factor-.alpha. (TNF-.alpha.) in a body fluid, an adsorber using the adsorbent and a process for adsorbing and removing TNF-.alpha., namely an adsorbent of TNF-.alpha., wherein onto a water-insoluble carrier a compound having a functional group represented by the formula (I): ##STR1## wherein X.sup.- is an anionic functional group, A is a substituent group except for the anionic functional group, n is an integer of 0 to 4 and in case n is at least 2, groups A, the number of which is n, may be the same or different from each other; a process for adsorbing and removing TNF-.alpha., which comprises coming the adsorbent into contact with a body fluid; and an adsorber for adsorbing TNF-.alpha. wherein a vessel having an inlet and an outlet for a body fluid and being equipped with a means for preventing the adsorbent from flowing to the outside of the vessel, is charged with the adsorbent.

    摘要翻译： 本发明涉及能够有效地去除体液中的肿瘤坏死因子-α（TNF-α）的吸附剂，使用吸附剂的吸附剂和吸附和去除TNF-α的方法，即TNF-α的吸附剂 其特征在于，在水不溶性载体上具有由式（I）表示的官能团的化合物：其中，X为阴离子官能团，A为阴离子官能团以外的取代基，n为0〜 4，在n至少为2的情况下，其数目为n的基团A可以相同或不同; 一种吸附和去除TNF-α的方法，其包括使吸附剂与体液接触; 和用于吸附TNF-α的吸附器，其中具有用于体液的入口和出口的容器并且装备有用于防止吸附剂流向容器外部的装置的吸附器装入吸附剂。