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    HEPATOCELLULAR CARCINOMA PROTEIN MARKER, AND METHOD FOR DETECTION OF HEPATOCELLULAR CARCINOMA USING THE SAME
    3.
    发明申请
    HEPATOCELLULAR CARCINOMA PROTEIN MARKER, AND METHOD FOR DETECTION OF HEPATOCELLULAR CARCINOMA USING THE SAME 失效
    肝细胞癌蛋白标记物及使用其检测肝细胞癌的方法

    公开(公告)号：US20100248256A1

    公开(公告)日：2010-09-30

    申请号：US12452216

    申请日：2008-06-16

    申请人： Hirotaka Minagawa ,  Kenji Miyazaki ,  Yo Tabuse ,  Kenichi Kamijo ,  Shuichi Kaneko

    发明人： Hirotaka Minagawa ,  Kenji Miyazaki ,  Yo Tabuse ,  Kenichi Kamijo ,  Shuichi Kaneko

    IPC分类号： G01N33/53 ,  C07K14/435

    CPC分类号： C07K14/4748 ,  G01N33/57438

    摘要： Provided are: a method of assessing hepatocellular carcinoma by using a protein with a different phosphorylated state in hepatocellular carcinoma cells compared with non-hepatocellular carcinoma cells; and a hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma formed of the protein. The hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma includes tumor rejection antigen gp96 formed of the amino acid represented by SEQ ID NO: 1, and is measured for its phosphorylated state to detect the presence or absence of hepatocellular carcinoma.

    摘要翻译： 提供：与非肝细胞癌细胞相比，通过使用肝细胞癌细胞中具有不同磷酸化状态的蛋白质来评估肝细胞癌的方法; 和用于检测由蛋白质形成的肝细胞癌的肝细胞癌蛋白标记物。 用于检测肝细胞癌的肝细胞癌蛋白标志物包括由SEQ ID NO：1表示的氨基酸形成的肿瘤排斥抗原gp96，并测量其磷酸化状态以检测肝细胞癌的存在或不存在。

    Method of forming low-resistance contact electrodes in semiconductor devices
    4.
    发明授权
    Method of forming low-resistance contact electrodes in semiconductor devices 有权

    公开(公告)号：US06524949B2

    公开(公告)日：2003-02-25

    申请号：US10003192

    申请日：2001-10-29

    申请人： Shuichi Kaneko ,  Hironori Aoki ,  Akio Iwabuchi

    发明人： Shuichi Kaneko ,  Hironori Aoki ,  Akio Iwabuchi

    IPC分类号： H01L214763

    CPC分类号： H01L21/76804

    摘要： There is formed on a semiconductor substrate a lamination of a first insulating film of nondoped silicon glass or the like and, on this first insulating film, a second insulating film of boron phosphor silicate glass or the like, with a conductor layer between the two insulating films. A hole is first dry-etched in the second insulating film, leaving the substrate surface covered by the first insulating film. Then the second insulating film is heated to a reflow temperature such that the hole is thermally deformed, flaring as it extends away from the insulating film. Then a second hole is dry-etched in the first insulating film through the first recited hole in the second insulating film, with the consequent exposure of the semiconductor surface. Then a contract electrode is fabricated by filling the first and the second hole with an electroconductive material into direct contact with the substrate surface. Being covered by the first insulating film, the substrate surface is not to be contaminated with impurities during the heating of the second insulating film.

    Method of forming low-resistance contact electrodes in semiconductor devices
    7.
    再颁专利
    Method of forming low-resistance contact electrodes in semiconductor devices 有权

    公开(公告)号：USRE40965E1

    公开(公告)日：2009-11-10

    申请号：US11065718

    申请日：2005-02-24

    申请人： Shuichi Kaneko ,  Hironori Aoki ,  Akio Iwabuchi

    发明人： Shuichi Kaneko ,  Hironori Aoki ,  Akio Iwabuchi

    IPC分类号： H01L21/4763

    CPC分类号： H01L21/76804

    摘要： There is formed on a semiconductor substrate a lamination of a first insulating film of nondoped silicon glass or the like and, on this first insulating film, a second insulating film of boron phosphor silicate glass or the like, with a conductor layer between the two insulating films. A hole is first dry-etched in the second insulating film, leaving the substrate surface covered by the first insulating film. Then the second insulating film is heated to a reflow temperature such that the hole is thermally deformed, flaring as it extends away from the insulating film. Then a second hole is dry-etched in the first insulating film through the first recited hole in the second insulating film, with the consequent exposure of the semiconductor surface. Then a contract electrode is fabricated by filling the first and the second hole with an electroconductive material into direct contact with the substrate surface. Being covered by the first insulating film, the substrate surface is not to be contaminated with impurities during the heating of the second insulating film.

    SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREOF
    8.
    发明申请
    SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREOF 审中-公开
    半导体器件及其制造方法

    公开(公告)号：US20120258578A1

    公开(公告)日：2012-10-11

    申请号：US13527163

    申请日：2012-06-19

    申请人： Hironori AOKI ,  Shuichi Kaneko

    发明人： Hironori AOKI ,  Shuichi Kaneko

    IPC分类号： H01L21/336

    CPC分类号： H01L29/7813 ,  H01L29/0696 ,  H01L29/0878 ,  H01L29/66734 ,  H01L29/7397

    摘要： A semiconductor device includes an epitaxial layer having a first conduction type, a base layer formed adjacent and on the epitaxial layer and having an opposite second conduction type to the first conduction type, a source layer formed selectively on the base layer and having the first conduction type, a trench which passes through the base layer and the source layer and which reaches the epitaxial layer, an insulation film formed along an interior wall of the trench, a control electrode formed within the trench via the insulation film, and a semiconductor region formed along the bottom part of the trench at the epitaxial layer and having the first conduction type.

    摘要翻译： 半导体器件包括具有第一导电类型的外延层，与外延层相邻并且在外延层上形成并具有与第一导电类型相反的第二导电类型的基极层，源层选择性地形成在基极层上并具有第一导电 类型，通过基底层和源极层并到达外延层的沟槽，沿着沟槽的内壁形成的绝缘膜，经由绝缘膜形成在沟槽内的控制电极和形成的半导体区域 沿着沟槽的底部在外延层处并具有第一导电类型。

    DETECTION OF DIGESTIVE ORGAN CANCER, GASTRIC CANCER, COLORECTAL CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY GENE EXPRESSION PROFILING
    9.
    发明申请
    DETECTION OF DIGESTIVE ORGAN CANCER, GASTRIC CANCER, COLORECTAL CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY GENE EXPRESSION PROFILING 有权
    根据基因表达分析检测消化性癌，胃癌，色素性癌，胰腺癌和胆汁性肝癌

    公开(公告)号：US20120157341A1

    公开(公告)日：2012-06-21

    申请号：US13391858

    申请日：2010-08-03

    申请人： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

    发明人： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

    IPC分类号： C40B30/04 ,  C40B40/06

    CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16

    摘要： The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.

    摘要翻译： 本发明提供了通过分析与消化器官癌相关的变化的表达水平（外周血）的基因来检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法和试剂， 胃癌，结肠直肠癌，胰腺癌或胆道癌，与正常健康人相比。 具体地，基于表达谱，检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法包括获得至少一种基因的表达谱，所述基因选自对应于具有 与正常健康受试者相比，消化器官癌，胃癌，结肠直肠癌，胰腺癌和胆道癌患者的表达水平（外周血）差异不大。 用于检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌的试剂含有由至少一种基因的核苷酸序列组成的核苷酸或其部分序列，所述核苷酸序列选自下组的探针：表达水平在 消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌，或含有与其互补的序列的核苷酸。

    Composition for treating hepatitis C
    10.
    发明授权
    Composition for treating hepatitis C 有权
    用于治疗丙型肝炎的组合物

    公开(公告)号：US07381435B2

    公开(公告)日：2008-06-03

    申请号：US10547548

    申请日：2004-03-04

    申请人： Satoshi Yoshida ,  Shuichi Kaneko

    发明人： Satoshi Yoshida ,  Shuichi Kaneko

    IPC分类号： A61K36/42 ,  A61K36/286 ,  A61K36/68 ,  A61K36/355

    CPC分类号： A61K36/286 ,  A61K36/355 ,  A61K36/42 ,  A61K36/68 ,  A61K2300/00

    摘要： By administering a composition comprising pumpkin seed, safflower, plantain and honeysuckle, subjective symptoms (for example, general malaise and abdominal swelling) of a patient with chronic hepatitis C can be eliminated and, moreover, objective symptoms diagnosed by a medical doctor (for example, liver enlargement and palm erythema) can be relieved or eliminated. From 1 to 3 months after the administration of the composition, a significant decrease in hepatitis C virus RNA level is gradually observed. Therefore, the above composition is useful at least as a composition for treating chronic hepatitis C. In particular, it is advantageous in treating a chronic hepatitis C patient showing a high chronic hepatitis C virus RNA level.

    摘要翻译： 通过施用包含南瓜籽，红花，车前草和金银花的组合物，可以消除患有慢性丙型肝炎患者的主观症状（例如，一般不适和腹部肿胀），此外，由医生诊断的客观症状（例如， ，肝肿大和棕红斑）可以缓解或消除。 在组合物施用后1至3个月，逐渐观察到丙型肝炎病毒RNA水平的显着降低。 因此，上述组合物至少可用作治疗慢性丙型肝炎的组合物。特别是，治疗显示高的慢性丙型肝炎病毒RNA水平的慢性丙型肝炎患者是有利的。