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    Adsorbent for immunoglobulins and complexes thereof, adsorption method, and adsorption device
    2.
    发明授权
    Adsorbent for immunoglobulins and complexes thereof, adsorption method, and adsorption device 有权
    免疫球蛋白吸附剂及其配合物，吸附方法和吸附装置

    公开(公告)号：US6133431A

    公开(公告)日：2000-10-17

    申请号：US117233

    申请日：1998-10-20

    申请人： Takamune Yasuda ,  Osamu Odawara ,  Eiji Ogino ,  Michio Nomura ,  Takahisa Nakai ,  Takashi Asahi ,  Nobutaka Tani

    发明人： Takamune Yasuda ,  Osamu Odawara ,  Eiji Ogino ,  Michio Nomura ,  Takahisa Nakai ,  Takashi Asahi ,  Nobutaka Tani

    IPC分类号： A61K35/14 ,  A61M1/36 ,  B01J20/32 ,  C07K17/00 ,  C07K17/02 ,  A61K39/00

    CPC分类号： C07K17/02 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3274 ,  B01J20/3282 ,  C07K17/00 ,  A61M1/3679 ,  A61M2202/0417

    摘要： An adsorbent that exhibits a high specificity in adsorbing immunoglobulins and/or complexes thereof, is extremely reduced in the lowering of the adsorption characteristic during sterilization or storage, is highly stable and safe, and is prepared by immobilizing on a water-insoluble support either a peptide derivative which has undergone at least one of the deletion, substitution, insertion, or addition of amino acids in a peptide having a specified amino acid sequence or an amino acid sequence, or the above peptide derivative which has undergone the addition of Lyn or Cys at the amino and/or carboxyl terminal thereof; a device for adsorption and removal made by packing the adsorbent in a vessel equipped with effluent preventing means; and a method of adsorbing and removing immunoglobulins and/or complexes thereof contained in the blood, plasma or other body fluids with the adsorbent.

    摘要翻译： PCT No.PCT / JP97 / 00161 Sec。 371日期：1998年10月20日 102（e）日期1998年10月20日PCT 1997年1月24日PCT公布。 第WO97 / 26930号公报 日期1997年7月31日在吸附免疫球蛋白和/或其复合物中显示高特异性的吸附剂在灭菌或储存期间吸附特性的降低极度降低，是高度稳定和安全的，并且通过固定在水上制备 - 不溶性支持已经在具有特定氨基酸序列或氨基酸序列的肽中经历了氨基酸的缺失，取代，插入或添加中的至少一个的肽衍生物，或上述已经经历 在其氨基和/或羧基末端添加Lyn或Cys; 用于通过将吸附剂包装在装有流出物防止装置的容器中而进行吸附和除去的装置; 以及利用吸附剂吸收和除去血液，血浆或其他体液中所含的免疫球蛋白和/或其复合物的方法。

    Adsorbent for bradykinin, method for eliminating the same by adsorption, and adsorber
    3.
    发明授权
    Adsorbent for bradykinin, method for eliminating the same by adsorption, and adsorber 失效
    用于缓激肽的吸附剂，通过吸附除去其的方法和吸附剂

    公开(公告)号：US06387362B1

    公开(公告)日：2002-05-14

    申请号：US09043537

    申请日：1998-08-14

    申请人： Fumiyasu Hirai ,  Nobutaka Tani ,  Takamune Yasuda ,  Takashi Asahi

    发明人： Fumiyasu Hirai ,  Nobutaka Tani ,  Takamune Yasuda ,  Takashi Asahi

    IPC分类号： A61K31795

    CPC分类号： B01J20/26 ,  A61M1/3679

    摘要： An adsorbent or bradykinin comprising styrene-divinylbenzene copolymer having sulfonic acid groups and a method for adsorbing and removing bradykinin comprising contacting the adsorbent with a fluid containing bradykinin are provided. An adsorber for adsorbing bradykinin in which the adsorbent is charged in a vessel having an inlet and an outlet for a fluid is also provided.

    摘要翻译： 提供了包含具有磺酸基的苯乙烯 - 二乙烯基苯共聚物的吸附剂或缓激肽以及吸收和去除缓激肽的方法，包括使吸附剂与含有缓激肽的流体接触。 还提供了用于吸附缓冲激肽的吸附剂，其中将吸附剂装入具有流体入口和出口的容器中。

    Process for adsorbing and removing tumor necrosis factor-.alpha.
    6.
    发明授权
    Process for adsorbing and removing tumor necrosis factor-.alpha. 有权
    吸附和去除肿瘤坏死因子-α的方法

    公开(公告)号：US06127528A

    公开(公告)日：2000-10-03

    申请号：US283964

    申请日：1999-04-02

    申请人： Fumiyasu Hirai ,  Nobutaka Tani ,  Takashi Asahi

    发明人： Fumiyasu Hirai ,  Nobutaka Tani ,  Takashi Asahi

    IPC分类号： C07K14/525 ,  C07K1/22 ,  A61K38/19 ,  C07K1/14 ,  C07K14/00

    CPC分类号： C07K14/525 ,  Y10S930/144

    摘要： The present invention relates to an adsorbent being capable of efficiently removing tumor necrosis factor-.alpha. (TNF-.alpha.) in a body fluid, an adsorber using the adsorbent and a process for adsorbing and removing TNF-.alpha., namely an adsorbent of TNF-.alpha., wherein onto a water-insoluble carrier a compound having a functional group represented by the formula (I): ##STR1## wherein X.sup.- is an anionic functional group, A is a substituent group except for the anionic functional group, n is an integer of 0 to 4 and in case n is at least 2, groups A, the number of which is n, may be the same or different from each other; a process for adsorbing and removing TNF-.alpha., which comprises coming the adsorbent into contact with a body fluid; and an adsorber for adsorbing TNF-.alpha. wherein a vessel having an inlet and an outlet for a body fluid and being equipped with a means for preventing the adsorbent from flowing to the outside of the vessel, is charged with the adsorbent.

    摘要翻译： 本发明涉及能够有效地去除体液中的肿瘤坏死因子-α（TNF-α）的吸附剂，使用吸附剂的吸附剂和吸附和去除TNF-α的方法，即TNF-α的吸附剂 其特征在于，在水不溶性载体上具有由式（I）表示的官能团的化合物：其中，X为阴离子官能团，A为阴离子官能团以外的取代基，n为0〜 4，在n至少为2的情况下，其数目为n的基团A可以相同或不同; 一种吸附和去除TNF-α的方法，其包括使吸附剂与体液接触; 和用于吸附TNF-α的吸附器，其中具有用于体液的入口和出口的容器并且装备有用于防止吸附剂流向容器外部的装置的吸附器装入吸附剂。

    Adsorbent for serum amyloid protein
    7.
    发明授权
    Adsorbent for serum amyloid protein 失效
    血清淀粉样蛋白用吸附剂

    公开(公告)号：US6037458A

    公开(公告)日：2000-03-14

    申请号：US948470

    申请日：1992-09-22

    申请人： Fumiyasu Hirai ,  Nobutaka Tani

    发明人： Fumiyasu Hirai ,  Nobutaka Tani

    IPC分类号： A61M1/34 ,  A61M1/36 ,  B01D15/00 ,  B01J20/32 ,  A23J1/00 ,  A61K35/14 ,  A61M37/00

    CPC分类号： A61M1/3486 ,  B01D15/00 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3274 ,  B01J20/328 ,  A61M1/3679

    摘要： An adsorbent for a serum amyloid protein, which comprises a water-insoluble carrier and either a compound selected from the group consisting of a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, said compound being immobilized onto said carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, said group being bonded to said carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.

    摘要翻译： 一种血清淀粉样蛋白的吸附剂，其包含水不溶性载体和选自具有阴离子官能团的化合物，具有多于一个阴离子官能团的聚阴离子化合物，苯胺和苯胺衍生物， 所述化合物被固定在所述载体上，或下式-NR 1 R 2基团，其中R 1是氢原子，甲基或乙基，R 2是满足log P值的原子团，其中P是分布 在水 - 辛醇体系中，式R2H的化合物的系数为0至3.2，所述基团键合到所述载体上，以及通过使用上述吸附剂的去除装置从体液中除去血清淀粉样蛋白的方法 。 根据本发明，SA蛋白质，特别是SAA蛋白质和SAP蛋白质可以选择性地从体液中除去而不会大大降低HDL。 此外，可以以低成本提供吸附剂。

    Adsorbent for serum amyloid protein
    8.
    发明授权
    Adsorbent for serum amyloid protein 失效
    血清淀粉样蛋白用吸附剂

    公开(公告)号：US5216127A

    公开(公告)日：1993-06-01

    申请号：US729234

    申请日：1991-07-12

    申请人： Fumiyasu Hirai ,  Nobutaka Tani

    发明人： Fumiyasu Hirai ,  Nobutaka Tani

    IPC分类号： A61M1/34 ,  A61M1/36 ,  B01D15/00 ,  B01J20/32

    CPC分类号： B01D15/00 ,  A61M1/3486 ,  B01J20/3204 ,  B01J20/3212 ,  B01J20/3248 ,  B01J20/3253 ,  A61M1/3679

    摘要： An adsorbent for a serum amyloid protein, which includes a water-insoluble carrier and either a compound selected from a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, the compound being immobilized onto the carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, the group being bonded to the carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.

    摘要翻译： 用于血清淀粉样蛋白的吸附剂，其包括水不溶性载体和选自具有阴离子官能团的化合物，具有多于一个阴离子官能团的聚阴离子化合物，苯胺和苯胺衍生物，所述化合物被固定 或载体，或下式的基团：-NR1R2，其中R1是氢原子，甲基或乙基，R2是满足logP值的原子团，其中P是水中的分布系数 正辛醇体系，R2H的化合物为0至3.2，该基团与载体结合，以及通过使用上述吸附剂的去除装置从体液中除去血清淀粉样蛋白的方法。 根据本发明，SA蛋白质，特别是SAA蛋白质和SAP蛋白质可以选择性地从体液中除去而不会大大降低HDL。 此外，可以以低成本提供吸附剂。

    MODIFIED ERYTHROPOIETIN TO WHICH WATER-SOLUBLE LONG-CHAIN MOLECULE IS ADDED
    9.
    发明申请
    MODIFIED ERYTHROPOIETIN TO WHICH WATER-SOLUBLE LONG-CHAIN MOLECULE IS ADDED 审中-公开
    添加了可溶性长链分子的改良的红细胞膜蛋白

    公开(公告)号：US20120264687A1

    公开(公告)日：2012-10-18

    申请号：US13395534

    申请日：2010-09-15

    申请人： Nobutaka Tani ,  Toshihide Fujii ,  Hiroyuki Watanabe ,  Hirofumi Maeda

    发明人： Nobutaka Tani ,  Toshihide Fujii ,  Hiroyuki Watanabe ,  Hirofumi Maeda

    IPC分类号： A61K38/18 ,  A61P7/06

    CPC分类号： A61K9/0019 ,  A61K38/1816 ,  A61K47/60

    摘要： An object of the invention is to provide a pharmaceutical composition that contains erythropoietin as the active ingredient and has, when administered in humans and/or animals, a hematopoietic effect that lasts for not less than seven days. The invention provides a pharmaceutical composition containing, in an amount equal to not less than 50% of the total erythropoietin, erythropoietin to which two or more water-soluble long-chain molecules are added. The invention also provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a molecular weight of not less than 30 kDa. The invention further provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a branched chain.

    摘要翻译： 本发明的目的是提供一种含有促红细胞生成素作为活性成分并且在人和/或动物中施用时持续不少于7天的造血作用的药物组合物。 本发明提供一种药物组合物，其含量等于不少于总促红细胞生成素的50％，红细胞生成素，其中加入了两种或更多种水溶性长链分子。 本发明还提供含有促红细胞生成素的药物组合物，其中加入水溶性长链分子，其中水溶性长链分子的分子量不小于30kDa。 本发明还提供含有促红细胞生成素的药物组合物，其中加入水溶性长链分子，其中所述水溶性长链分子具有支链。