公开(公告)号：US20190145405A1

公开(公告)日：2019-05-16

申请号：US15769818

申请日：2016-10-28

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： Andreas Torbjorn Lundin

IPC: F04C2/08 ,  F04C2/10 ,  F04C15/00

Abstract: Disclosed is a gear pump (10) comprising a contra rotating gear element pair (30 and 40) mounted within a housing (20), each gear element having complementary gear teeth sets providing a pumping action in use, said teeth being formed from an annulus (34 and 44) of generally rigid construction mounted on a relatively flexible inner section (35 and 45), the gear pair being mounted such that their respective annuli are biased into resilient contact with the housing to provide a sliding seal.

公开(公告)号：US11686726B2

公开(公告)日：2023-06-27

申请号：US16470607

申请日：2017-12-27

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Ola Lind ,  Johan Fredrik Avallin ,  Andreas Torbjorn Lundin ,  Nils Norrman ,  Ronnie Palmgren ,  Gustav Jose Rodrigo

IPC: G01N33/543 ,  C12M3/00 ,  C12M3/06 ,  C12M1/00 ,  C12M1/34 ,  C12N13/00 ,  B01D21/00 ,  B03C5/00 ,  B03C5/02 ,  B03C1/30 ,  B03C1/28 ,  B03C1/01

CPC classification number: G01N33/54326 ,  B01D21/0009 ,  B03C1/30 ,  B03C5/00 ,  B03C5/02 ,  C12M23/48 ,  C12M27/16 ,  C12M29/00 ,  C12M41/44 ,  C12M45/07 ,  C12M47/04 ,  C12M47/10 ,  C12N13/00 ,  G01N33/5436 ,  B03C1/01 ,  B03C1/288 ,  B03C2201/26 ,  G01N2333/31

Abstract: A separation system, a method in a separation system and an elution arrangement to be provided in a separation system for separating a biomolecule from a cell culture are provided. The method comprises the steps of: —providing a feed from a cell culture (3; 103; 203) comprising said biomolecule to a magnetic separator (5; 105; 205) and providing to the magnetic separator magnetic beads comprising ligands capable of binding this biomolecule; —separating by the magnetic separator said magnetic beads with bound biomolecules from the rest of the feed; —forwarding said magnetic beads as a slurry with an added buffer to an elution cell (7; 107; 207); —eluting the bound biomolecules in the elution cell.

公开(公告)号：US20200009557A1

公开(公告)日：2020-01-09

申请号：US16486736

申请日：2018-02-27

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Tuomo Valtteri Frigard ,  Robert Magnusson ,  Mats Lundkvist ,  Karl Axel Jakob Liderfelt ,  Helena Nordvarg ,  Andreas Torbjorn Lundin ,  Peter Arne Reffner

IPC: B01L3/00 ,  B01D15/10 ,  B01D61/14

Abstract: Disclosed is a modular bio-processing unit (100) comprising: a housing (110) having one or more internal fluid paths (101), the housing having at least one inlet and at least one outlet (5,10,15,20,25,30,35,40,45,50,55,60,65,70), each in fluid communication with the fluid path or one or more of the fluid paths; one or more sensor elements (120,150,170,190) operatively associated with the or each path, said sensor(s) elements including elements of one or more of: a flow sensor, a flow rate sensor, a conductivity sensor, a pressure sensor, a pH sensor, and a light absorbance sensor such as a UV spectroscopic concentration sensor; one or more fluid flow inducing components (140) operatively associated with the or each fluid path; and plural valves (180) for preventing or reducing flow in the or each path, the housing, inlet(s), outlet(s), flow inducing component(s) and valve(s) being arranged to operate together as a bio-processing unit within or substantially within the housing.

公开(公告)号：US20200087614A1

公开(公告)日：2020-03-19

申请号：US16470607

申请日：2017-12-27

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Ola Lind ,  Johan Fredrik Avallin ,  Andreas Torbjorn Lundin ,  Nils Norrman ,  Ronnie Palmgren ,  Gustav Jose Rodrigo

IPC: C12M1/00 ,  C12N13/00

Abstract: A separation system, a method in a separation system and an elution arrangement to be provided in a separation system for separating a biomolecule from a cell culture are provided. The method comprises the steps of: —providing a feed from a cell culture (3; 103; 203) comprising said biomolecule to a magnetic separator (5; 105; 205) and providing to the magnetic separator magnetic beads comprising ligands capable of binding this biomolecule; —separating by the magnetic separator said magnetic beads with bound biomolecules from the rest of the feed; —forwarding said magnetic beads as a slurry with an added buffer to an elution cell (7; 107; 207); —eluting the bound biomolecules in the elution cell.

公开(公告)号：US10451591B1

公开(公告)日：2019-10-22

申请号：US15188102

申请日：2016-06-21

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Klaus Gebauer ,  Stefan Sjolander ,  Andreas Torbjorn Lundin

IPC: G01N30/38 ,  F16K7/07 ,  F16K31/02

Abstract: The invention relates to valve system for controlling a process fluid within a liquid processing system. The valve system comprises a valve arrangement, a pneumatic or hydraulic control system, and a connector unit. When the valve arrangement is connected to the connector unit, two or more valves are formed, such that the pneumatic or hydraulic control system controls an open/close or pressure control mode of the valves. A pump diaphragm system is disclosed, as well as a system for purifying a biological material that comprises the valve system or the pump diaphragm system. Also discloses are methods of using the valve system or the pump diaphragm system in a process for the purification of a biological material.