公开(公告)号：US20180275104A1

公开(公告)日：2018-09-27

申请号：US15763520

申请日：2016-09-29

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： Helena Skoglar ,  Bjorn Olovsson

IPC: G01N30/38 ,  G01N30/74 ,  G01N30/20 ,  G01N30/78 ,  B01D15/18

CPC classification number: G01N30/38 ,  B01D15/1807 ,  B01D15/1885 ,  G01N30/20 ,  G01N30/42 ,  G01N30/74 ,  G01N30/78 ,  G01N35/1097 ,  G01N2030/202 ,  G01N2030/385 ,  G01N2030/626

Abstract: The present invention relates to a chromatography system and a method therefor. The chromatography system comprising an inlet port (102) for receiving a sample, an outlet port (106) for delivering the sample, a detector (201), a column (104), and a valve (202) in fluid communication with the inlet port, the outlet port, the detector, and the column. The valve (202) comprises a first position (304) wherein the inlet port is in fluid communication with the outlet port via a first fluid path comprising the detector and the column, wherein the detector is arranged upstream the column. The valve comprises a second position (404) wherein the inlet port is in fluid communication with the outlet port via a second fluid path comprising the detector and the column, wherein the detector is arranged downstream the column.

公开(公告)号：US20200378934A1

公开(公告)日：2020-12-03

申请号：US16995933

申请日：2020-08-18

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Petra Bangtsson ,  Erik Estrada ,  Karol Lacki ,  Helena Skoglar

IPC: G01N30/88 ,  G01N30/78 ,  G01N30/46 ,  B01D15/18 ,  G01N30/42 ,  B01D15/42

Abstract: There is provided a method and a corresponding system for determining binding capacities of a chromatography column. The method includes detecting a feed signal representative of the composition of a feed material provided to the inlet of the column. The method further includes detecting an effluent signal representative of the composition of the effluent from the column. The method further includes using the feed signal and the effluent signal to determine binding capacities of the column.

公开(公告)号：US20200054964A1

公开(公告)日：2020-02-20

申请号：US16487607

申请日：2018-02-14

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Hans Blom ,  Mikael Berg ,  Hanno Ehring ,  Linda Mathiasson ,  Helena Skoglar ,  Rebecka Chmielowski

IPC: B01D15/18 ,  B01D15/16 ,  C07K1/16 ,  G01N30/74 ,  G01N30/42 ,  G01N30/88

Abstract: The present invention relates to a method for determining operational status of a chromatography column (1; 39, 47, 59; 107, 109, 111, 113), comprising detecting a feed signal (21; 201) representative of the composition of a feed material provided to the inlet of the column; detecting the UV absorbance in the feed material, detecting an effluent signal (23; 203, 205, 207, 209) representative of the composition of the effluent from the column; and using the feed signal and the effluent signal to determine operational status of the column. The feed signal is generated using a first UV detector having a first UV cell pathlength operating at a first UV wavelength and in the effluent signal is generated using a second UV detector having a second UV cell pathlength operating at a second UV wavelength. The method further comprising determining a first threshold value based on the detected UV absorbance in the feed material, and selecting the first UV cell pathlength and/or first UV wavelength based on the first threshold value.

公开(公告)号：US20190336886A1

公开(公告)日：2019-11-07

申请号：US16474455

申请日：2017-12-22

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Key Hyckenberg ,  Mikael Johan Helmer Eugen Berg ,  Helena Skoglar ,  Gunnar Malmquist ,  Linda Mathiasson ,  Lars Henning Ivar Mattsson ,  Sara Sendabo

IPC: B01D15/18 ,  G01N30/46 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M1/26

Abstract: The present invention relates to a method for controlling a bioprocess purification system comprising a continuous chromatography configured to operate with at least three columns and configured for cyclic operation, wherein the continuous purification is performed on a sample comprising a target product having desired characteristics. The method comprises detecting (82) at least one parameter indicative of characteristics of the target product, performing (83) real time trend analysis of each detected at least one parameter to identify a deviation from the desired characteristics of the target product, and controlling (84) the bioprocess purification system to meet the desired characteristics based on the identified deviation, whereby the target characteristics is within a pre-determined range.