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公开(公告)号：US20190010479A1
公开(公告)日：2019-01-10
申请号：US15578488
申请日：2016-05-26
Applicant: GENOMATICA, INC. , BRASKEM S.A.
Inventor： Stephanie J. CULLER , Robert J. HASELBECK , Harish NAGARAJAN , Iuri Estrada GOUVEA , Daniel Johannes KOCH , Mateus Schreiner Garcez LOPES , Lucas Pedersen PARIZZI
Abstract: In alternative embodiments, provided are non-natural or genetically engineered vinylisomerase-dehydratase enzymes, including alkenol dehydratases, linalool dehydratases and crotyl alcohol dehydratases. In alternative embodiments, provided are non-natural or genetically engineered polypeptides having an activity comprising, for example, a vinylisomerase-dehydratase, an alkenol dehydratase, a linalool dehydratase and/or a crotyl alcohol dehydratase activity, or a combination thereof. In alternative embodiments, also provided are non-natural or genetically engineered nucleic acids (polynucleotides) encoding polypeptides described herein, expression or cloning vehicles comprising or having contained therein nucleic acids as described herein, and non-natural or genetically engineered cells comprising or having contained therein nucleic acids as described herein. In alternative embodiments, also provided are methods for making various organic compounds, including methyl vinyl carbinol and butadiene.
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公开(公告)号：US20220298535A1
公开(公告)日：2022-09-22
申请号：US17750293
申请日：2022-05-20
Applicant: Braskem S.A.
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
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公开(公告)号：US20220064682A1
公开(公告)日：2022-03-03
申请号：US17463988
申请日：2021-09-01
Applicant: Braskem S.A.
Inventor： Iuri Estrada GOUVEA , Ana Karina BRAMBILLA COSTA , Marcos Rogerio SIMOES , Veronica Leite QUEIROZ , Aline Silva ROMÃO DUMARESQ
Abstract: The present disclosure provides recombinant microorganisms and methods for the anaerobic production of 2,4-furandimethanol from one or more carbon sources. The microorganisms and methods provide redox-balanced and ATP positive pathways for co-producing 2,4-furandimethanol with ethanol and for co-producing 2,4-furandimethanol with ethanol and acetone and/or isopropanol. The method provides recombinant microorganisms that express endogenous and/or exogenous nucleic acid molecules encoding polypeptides that catalyze the conversion of a carbon source into 2,4-furandimethanol and that couple the 2,4-furandimethanol pathway with an additional metabolic pathway. The present disclosure further provides enzymatic production of 2,4-furandicarboxylic acid.
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公开(公告)号：US20230279365A1
公开(公告)日：2023-09-07
申请号：US18084888
申请日：2022-12-20
Applicant: Braskem S.A.
Inventor： Verônica Leite QUEIROZ , Lucas Pedersen PARIZZI , Iuri Estrada GOUVEA , Debora Noma OKAMOTO , Rafael Victório Carvalho GUIDO , Alessandro Silva NASCIMENTO , Igor POLIKARPOV
CPC classification number: C12N9/0006 , C12N15/52 , C12Y101/01001
Abstract: The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides.
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公开(公告)号：US20210238639A1
公开(公告)日：2021-08-05
申请号：US17219792
申请日：2021-03-31
Applicant: Braskem S.A.
Inventor： Paulo Moises Raduan ALEXANDRINO , Iuri Estrada GOUVEA , Veronica Leite QUEIROZ , Felipe Cicaroni FERNANDES , Bárbara MANO
IPC: C12P17/04 , C07D307/68
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
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Patent Agency Ranking
公开(公告)号：US20220243006A1
公开(公告)日：2022-08-04
申请号：US17586535
申请日：2022-01-27
Applicant: Braskem S.A.
Inventor： Felipe Cicaroni FERNANDES , Iuri Estrada GOUVEA , Bárbara MANO
IPC: C08G63/183 , C08G63/40
Abstract: The present disclosure provides a copolyester including a dicarboxylic acid component A comprising a terephthalic acid residue or ester-forming derivative thereof, or a mixture thereof, and a 2,4-furandicarboxylic acid residue or ester-forming derivative thereof, or a mixture thereof, and a diol component B comprising an alkanediol residue having from 2 to 22 carbon atoms, wherein the dicarboxylic acid component A has a total molar content, and wherein the 2,4-furandicarboxylic acid residue or ester-forming derivative thereof, is present in an amount of from 0.1 to 10 mol %, with respect to the total molar content of the dicarboxylic acid component A. Inventive copolyesters have a slower crystallization rate, a higher gas barrier to CO2 and O2 and a higher ratio of 14C to 12C as measured by ASTM D6866 when compared to a comparable copolyester comprising isophthalic acid instead of 2,4-furandicarboxylic acid.
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公开(公告)号：US20210222217A1
公开(公告)日：2021-07-22
申请号：US17163838
申请日：2021-02-01
Applicant: Braskem S.A.
Inventor： Paulo Moises Raduan ALEXANDRINO , Iuri Estrada GOUVEA , Veronica Leite QUEIROZ , Marcos Rogerio SIMÕES
IPC: C12P17/04 , C07D307/68
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-IMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
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公开(公告)号：US20200277639A1
公开(公告)日：2020-09-03
申请号：US16806728
申请日：2020-03-02
Applicant: Braskem S.A.
IPC: C12P17/04 , C07D307/68
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
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公开(公告)号：US20190309266A1
公开(公告)日：2019-10-10
申请号：US16378209
申请日：2019-04-08
Applicant: Braskem S.A.
Inventor： Verônica Leite QUEIROZ , Lucas Pedersen PARIZZI , Iuri Estrada GOUVEA , Debora Noma OKAMOTO , Rafael Victório Carvalho GUIDO , Alessandro Silva NASCIMENTO , Igor POLIKARPOV
Abstract: The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides.
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公开(公告)号：US20220090153A1
公开(公告)日：2022-03-24
申请号：US17545616
申请日：2021-12-08
Applicant: Braskem S.A.
Inventor： Iuri Estrada GOUVEA , Paulo Moises Raduan ALEXANDRINO
IPC: C12P17/04 , C07D307/68
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
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