公开(公告)号：US20230390381A1

公开(公告)日：2023-12-07

申请号：US18082456

申请日：2022-12-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Ann-Muriel STEFF ,  Jean-Francois TOUSSAINT ,  Alessandra VITELLI

IPC: A61K39/155 ,  A61K39/235 ,  A61K39/12

CPC classification number: A61K39/155 ,  A61K39/235 ,  A61K39/12 ,  A61K2039/5256

Abstract: This disclosure provides immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic component containing a nucleic acid encoding an antigen of the same respiratory pathogen, wherein the immunogenic components are formulated for concurrent, e.g., co-localized, administration. More specifically, the respiratory pathogen is respiratory syncytial virus (RSV). This disclosure also concerns provides the use of such immunogenic combinations, and methods for administering such immunogenic combinations to elicit an immune response specific for the respiratory pathogen.

公开(公告)号：US20220184158A1

公开(公告)日：2022-06-16

申请号：US17416642

申请日：2019-12-20

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Jean-Francois TOUSSAINT ,  Vanesa BOL

IPC: A61K35/768 ,  A61K39/12 ,  A61K38/17 ,  A61P35/00 ,  C12N7/00

Abstract: There is provided inter alia a method of treating cancer in a mammal, said method comprising the steps of: (i) administering to the mammal a first composition comprising an antigen or comprising a nucleic acid encoding an antigen and (ii) administering to the mammal a second composition comprising an oncolytic virus wherein the oncolytic virus comprises a nucleic acid encoding the antigen.

公开(公告)号：US20170143820A1

公开(公告)日：2017-05-25

申请号：US15318490

申请日：2015-06-12

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Ann-Muriel STEFF ,  Jean-Francois TOUSSAINT ,  Alessandra VITELLI

IPC: A61K39/155

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K39/235 ,  A61K2039/5256 ,  A61K2039/545 ,  C12N2710/10343 ,  C12N2760/18534

Abstract: Immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic component containing a nucleic acid encoding an antigen of the same respiratory pathogen, wherein the immunogenic components are formulated for concurrent administration are provided, as well as methods for making and for administering such immunogenic combinations to elicit an immune response specific for the respiratory pathogen.

公开(公告)号：US20160120972A1

公开(公告)日：2016-05-05

申请号：US14992354

申请日：2016-01-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Benoit BARAS ,  Dirk GHEYSEN ,  Isabelle Solange Lucie KNOTT ,  Jean-Paul PRIEELS ,  Jean-Francois TOUSSAINT

IPC: A61K39/12

CPC classification number: A61K39/12 ,  A61K2039/5252 ,  A61K2039/55 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/55583 ,  C12N2770/24134 ,  Y02A50/386

Abstract: The present disclosure provides immunogenic compositions for the prevention and/or treatment of disease caused by dengue virus.

Abstract translation: 本公开提供用于预防和/或治疗由登革热病毒引起的疾病的免疫原性组合物。