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![Crystalline form of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and pharmaceutical composition comprising same](/abs-image/US/2018/06/05/US09988372B2/abs.jpg.150x150.jpg)
公开(公告)号：US09988372B2
公开(公告)日：2018-06-05
申请号：US15325521
申请日：2014-07-18
Applicant: GREEN CROSS CORPORATION , LEGOCHEM BIOSCIENCES,INC.
Inventor： Soongyu Choi , Jungsub Choi , So-Hyun Yoon , Yoo Hoon Kim , Jae Yeon Kim , Suk Ho Lee , Young Lag Cho , Ho Young Song , Dae Yon Lee , Sung Yoon Baek , Sang Eun Chae , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
IPC: C07D253/065 , C07D409/10 , C07D413/10 , A61K31/53 , C07D413/14
CPC classification number: C07D413/14 , A61K31/53 , A61P7/02 , A61P9/00 , A61P29/00 , C07B2200/13 , C07D253/065 , C07D409/10
Abstract: The present invention relates to a novel crystalline form of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and a pharmaceutical composition containing the same. The novel crystalline form of a compound according to the present invention exhibits excellent stability even in high-temperature and humidity environments, and thus can be favorably used to prevent or treat diseases, such as thrombosis, myocardial infarction, atherosclerosis, inflammation, stroke, angina pectoris, restenosis after angioplasty, and thromboembolism.
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公开(公告)号：US20180353611A1
公开(公告)日：2018-12-13
申请号：US16005245
申请日：2018-06-11
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jung Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC: A61K47/68 , C07K19/00 , C07K16/32 , C07D519/00 , C07D487/04 , C07D249/04 , A61K47/54 , A61K47/69 , A61K39/00
CPC classification number: A61K47/6871 , A61K47/50 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24 , C07K2317/94
Abstract: Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US09919057B2
公开(公告)日：2018-03-20
申请号：US14865778
申请日：2015-09-25
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Jeon Yang , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung
IPC: C07D309/10 , A61K47/48 , C07D249/04 , C07K19/00
CPC classification number: A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
Abstract: Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US20160184451A1
公开(公告)日：2016-06-30
申请号：US14865778
申请日：2015-09-25
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Jeon Yang , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung
IPC: A61K47/48
CPC classification number: A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
Abstract: Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
Abstract translation: 本发明提供的是包含自褪色基团的化合物，并且包含本发明的自褪色组的化合物可以包括具有底物特异性的蛋白质（例如寡肽，多肽，抗体等） 具有特定功能或活性的靶和活性剂（例如药物，毒素，配体，检测探针等）。
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公开(公告)号：US10383949B2
公开(公告)日：2019-08-20
申请号：US16005245
申请日：2018-06-11
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC: A61K47/68 , C07D249/04 , C07K19/00 , C07K16/32 , A61K47/69 , C07D487/04 , C07D519/00 , A61K47/54 , A61K47/50 , A61K39/00
Abstract: Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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Patent Agency Ranking
公开(公告)号：US20170095576A1
公开(公告)日：2017-04-06
申请号：US14898932
申请日：2015-05-27
Applicant: LEGOCHEM BIOSCIENCES, INC.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
CPC classification number: A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
Abstract: Provided are methods of use of compounds comprising a self-immolative group, which compounds may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US10980890B2
公开(公告)日：2021-04-20
申请号：US16545869
申请日：2019-08-20
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC: A61K47/54 , C07K19/00 , C07D487/04 , C07D519/00 , A61K47/68 , A61K47/50 , C07D249/04 , C07K16/32 , A61K47/69 , A61K39/00
Abstract: Provided herein are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US20200069816A1
公开(公告)日：2020-03-05
申请号：US16545869
申请日：2019-08-20
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC: A61K47/68 , A61K47/69 , C07K16/32 , C07D249/04 , A61K47/54 , C07D519/00 , C07D487/04 , C07K19/00 , A61K47/50
Abstract: Provided herein are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US09993568B2
公开(公告)日：2018-06-12
申请号：US14898932
申请日：2015-05-27
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
CPC classification number: A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
Abstract: Provided are methods of use of compounds comprising a self-immolative group, which compounds may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US09630977B2
公开(公告)日：2017-04-25
申请号：US13691221
申请日：2012-11-30
Applicant: Legochem Biosciences, Inc.
Inventor： Young Lag Cho , Joung Yul Yun , Sang Eun Chae , Chul Soon Park , Hyang Sook Lee , Kyu Man Oh , Hye Jin Heo , Dae Hyuck Kang , Young Jae Yang , Hyun Jin Kwon , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
IPC: C07D501/24 , C07D501/46 , C07D501/60
CPC classification number: C07D501/60 , C07D501/24 , C07D501/46
Abstract: The present invention relates to novel cephalosporin derivatives represented by X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.
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