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公开(公告)号：US11020358B2
公开(公告)日：2021-06-01
申请号：US15593141
申请日：2017-05-11
Inventor： Tzyy-Wen Chiou , Horng-Jyh Harn , Shinn-Zong Lin , Karthyayani Rajamani , Yi-Chun Lin
IPC: A61K31/11 , A61K35/28 , A61K35/545
Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.
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Patent Agency Ranking
公开(公告)号：US20230233613A1
公开(公告)日：2023-07-27
申请号：US17963219
申请日：2022-10-11
Inventor： Po-Cheng Lin , Pi-Chun Huang , Chia-Hsin Lee , Ming-Hsi Chuang , Chun-Hung Chen , Chao-Liang Chang , Kai-Ling Zhang , Yi-Chun Lin , Yu-Chen Tsai , Peggy Leh Jiunn Wong , Ruei-Yue Liang
IPC: A61K35/28 , A61K9/00 , C12N5/0789
CPC classification number: A61K35/28 , A61K9/0085 , A61K9/0019 , C12N5/0647 , C12N2501/10 , C12N2502/1382 , C12N2501/2304 , C12N2501/2313
Abstract: The present invention provides a pharmaceutical composition for treating chronic stroke, involving injection via brain into the cranium of a patient having chronic stroke for six months or more; the pharmaceutical composition is a suspension at least comprising TS stem cells, an active synergistic component and a growth factor, wherein the expression level of CD34 and CD45 of the TS stem cells is 10% or less, and the expression level of CD90 and CD105 is 90% or more; the active synergistic component is an extracellular vesicle; the growth factor is at least one selected from the group consisting of HGF, G-CSF, Fractalkine, IP-10, EGF, IL-1α, IL-1β, IL-4, IL-5, IL-13, IFNγ, TGFα and sCD40L. The present invention overcomes the limitations of previous cell therapy and provides a cell-based preparation that is clinically safe and therapeutically effective for chronic cerebral stroke.
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公开(公告)号：US20170246123A1
公开(公告)日：2017-08-31
申请号：US15593141
申请日：2017-05-11
Inventor： Tzyy-Wen CHIOU , Horng-Jyh Harn , Shinn-Zong Lin , Karthyayani Rajamani , Yi-Chun Lin
IPC: A61K31/11 , A61K35/545 , A61K35/28
CPC classification number: A61K31/11 , A61K35/28 , A61K35/545
Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.
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公开(公告)号：US20240115616A1
公开(公告)日：2024-04-11
申请号：US18376545
申请日：2023-10-04
Inventor： Po-Cheng Lin , Pi-Chun Huang , Zih-Han Hong , Ming-Hsi Chuang , Yi-Chun Lin , Chia-Hsin Lee , Chun-Hung Chen , Chao-Liang Chang , Kai-Ling Zhang
IPC: A61K35/28 , A61K9/00 , A61K9/127 , A61P1/16 , C12N5/0775
CPC classification number: A61K35/28 , A61K9/0019 , A61K9/127 , A61P1/16 , C12N5/0667 , C12N2500/02
Abstract: The present disclosure provides a method for treating liver cirrhosis by using a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors. The composition of the present disclosure achieves the effect of treating liver cirrhosis through various efficacy experiments.
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公开(公告)号：US20180311185A1
公开(公告)日：2018-11-01
申请号：US16034234
申请日：2018-07-12
Inventor： Tzyy-Wen CHIOU , Horng-Jyh Harn , Shinn-Zong Lin , Karthyayani Rajamani , Yi-Chun Lin
IPC: A61K31/11 , A61K35/545 , A61K35/28
CPC classification number: A61K31/11 , A61K35/28 , A61K35/545
Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.
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公开(公告)号：US20160106783A1
公开(公告)日：2016-04-21
申请号：US14643977
申请日：2015-03-10
Inventor： Tzyy-Wen CHIOU , Horng-Jyh Harn , Shinn-Zong Lin , Karthyayani Rajamani , Yi-Chun Lin
CPC classification number: A61K31/11 , A61K35/28 , A61K35/545
Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.
Abstract translation: 提供了一种用于干细胞抗衰老和/或恢复活力的方法。 该方法包括用反式肉桂醛（TC）处理干细胞。 还提供套件。 该试剂盒包括（1）第一部分，包括干细胞; （2）第二部分，包括TC; 和（3）干细胞的培养基，放置在第一部分，第二部分和第三部分中的至少一个中。 此外，提供了一种用于干细胞治疗的方法。 该方法包括向有需要的受试者施用有效量的干细胞，其中干细胞在施用前已用TC治疗。
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