公开(公告)号：US20250092356A1

公开(公告)日：2025-03-20

申请号：US18964649

申请日：2024-12-01

Applicant: Gwo Xi Stem Cell Applied Technology Co., Ltd.

Inventor： Ruei-Yue Liang ,  Kai-Ling Zhang ,  Ming-Hsi Chuang ,  Po-Cheng Lin ,  Chun-Hung Chen ,  Pei-Syuan Chao

IPC: C12N5/00 ,  C12N5/071

Abstract: The present invention relates to a cell differentiation medium composition, a high secretion insulin-producing cells and a preparation method thereof. The high secretion insulin-producing cells obtained by using the cell differentiation medium composition to induce stem cell differentiated under specific conditions can secrete a large amount of insulin in a short time, and when the high-secreting insulin-producing cells are transplanted into the human body, they are not easy to be swallowed by macrophages, which can improve the survival rate of the insulin-producing cells and prolong the time of insulin secretion thereby.

公开(公告)号：US20230233613A1

公开(公告)日：2023-07-27

申请号：US17963219

申请日：2022-10-11

Applicant: Gwo Xi Stem Cell Applied Technology Co., Ltd.

Inventor： Po-Cheng Lin ,  Pi-Chun Huang ,  Chia-Hsin Lee ,  Ming-Hsi Chuang ,  Chun-Hung Chen ,  Chao-Liang Chang ,  Kai-Ling Zhang ,  Yi-Chun Lin ,  Yu-Chen Tsai ,  Peggy Leh Jiunn Wong ,  Ruei-Yue Liang

IPC: A61K35/28 ,  A61K9/00 ,  C12N5/0789

CPC classification number: A61K35/28 ,  A61K9/0085 ,  A61K9/0019 ,  C12N5/0647 ,  C12N2501/10 ,  C12N2502/1382 ,  C12N2501/2304 ,  C12N2501/2313

Abstract: The present invention provides a pharmaceutical composition for treating chronic stroke, involving injection via brain into the cranium of a patient having chronic stroke for six months or more; the pharmaceutical composition is a suspension at least comprising TS stem cells, an active synergistic component and a growth factor, wherein the expression level of CD34 and CD45 of the TS stem cells is 10% or less, and the expression level of CD90 and CD105 is 90% or more; the active synergistic component is an extracellular vesicle; the growth factor is at least one selected from the group consisting of HGF, G-CSF, Fractalkine, IP-10, EGF, IL-1α, IL-1β, IL-4, IL-5, IL-13, IFNγ, TGFα and sCD40L. The present invention overcomes the limitations of previous cell therapy and provides a cell-based preparation that is clinically safe and therapeutically effective for chronic cerebral stroke.

公开(公告)号：US20240115616A1

公开(公告)日：2024-04-11

申请号：US18376545

申请日：2023-10-04

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Po-Cheng Lin ,  Pi-Chun Huang ,  Zih-Han Hong ,  Ming-Hsi Chuang ,  Yi-Chun Lin ,  Chia-Hsin Lee ,  Chun-Hung Chen ,  Chao-Liang Chang ,  Kai-Ling Zhang

IPC: A61K35/28 ,  A61K9/00 ,  A61K9/127 ,  A61P1/16 ,  C12N5/0775

CPC classification number: A61K35/28 ,  A61K9/0019 ,  A61K9/127 ,  A61P1/16 ,  C12N5/0667 ,  C12N2500/02

Abstract: The present disclosure provides a method for treating liver cirrhosis by using a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors. The composition of the present disclosure achieves the effect of treating liver cirrhosis through various efficacy experiments.

公开(公告)号：US12195754B2

公开(公告)日：2025-01-14

申请号：US17235910

申请日：2021-04-20

Applicant: Gwo Xi Stem Cell Applied Technology Co., Ltd.

Inventor： Ruei-Yue Liang ,  Kai-Ling Zhang ,  Ming-Hsi Chuang ,  Po-Cheng Lin ,  Chun-Hung Chen ,  Pei-Syuan Chao

IPC: C12N5/00 ,  C12N5/071

Abstract: The present invention relates to a cell differentiation medium composition, a high secretion insulin-producing cells and a preparation method thereof. The high secretion insulin-producing cells obtained by using the cell differentiation medium composition to induce stem cell differentiated under specific conditions can secrete a large amount of insulin in a short time, and when the high-secreting insulin-producing cells are transplanted into the human body, they are not easy to be swallowed by macrophages, which can improve the survival rate of the insulin-producing cells and prolong the time of insulin secretion thereby.

公开(公告)号：US20230201266A1

公开(公告)日：2023-06-29

申请号：US17470487

申请日：2021-09-09

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Feng-Huei Lin ,  Che-Yung Kuan ,  Yu-Ying Lin ,  Ching-Yun Chen ,  Zhi-Yu Chen ,  I-Hsuan Yang ,  Ming-Hsi Chuang ,  Po-Cheng Lin ,  Chia-Hsin Lee ,  Kai-Ling Zhang ,  Pei-Syuan Chao ,  Wan-Sin Syu ,  Chun-Hung Chen ,  Ting-Ju Wang

IPC: A61K35/28 ,  A61P19/02 ,  C12N5/0775 ,  C12N5/00

CPC classification number: A61K35/28 ,  A61P19/02 ,  C12N5/0062 ,  C12N5/0667 ,  C12N2513/00 ,  C12N2533/30

Abstract: The present disclosure provides a method for treating arthritis by using a stem cell preparation. The stem cell preparation of the present disclosure can effectively delay cartilage degeneration caused by arthritis, and it is confirmed by whole blood analysis and blood biochemical analysis that the stem cell preparation in the form of three-dimensional stem cell spheres provides a safe treatment for arthritis. The present disclosure also provides a method for preparing the stem cell preparation.

公开(公告)号：US20210371812A1

公开(公告)日：2021-12-02

申请号：US17235910

申请日：2021-04-20

Applicant: Gwo Xi Stem Cell Applied Technology Co., Ltd.

Inventor： Ruei-Yue Liang ,  Kai-Ling Zhang ,  Ming-Hsi Chuang ,  Po-Cheng Lin ,  Chun-Hung Chen ,  Pei-Syuan Chao

IPC: C12N5/00 ,  C12N5/071

Abstract: The present invention relates to a cell differentiation medium composition, a high secretion insulin-producing cells and a preparation method thereof. The high secretion insulin-producing cells obtained by using the cell differentiation medium composition to induce stem cell differentiated under specific conditions can secrete a large amount of insulin in a short time, and when the high-secreting insulin-producing cells are transplanted into the human body, they are not easy to be swallowed by macrophages, which can improve the survival rate of the insulin-producing cells and prolong the time of insulin secretion thereby.

公开(公告)号：US20240124844A1

公开(公告)日：2024-04-18

申请号：US18376459

申请日：2023-10-04

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Chia-Hsin Lee ,  Po-Cheng Lin ,  Yong-Cheng Kao ,  Ming-Hsi Chuang ,  Chun-Hung Chen ,  Chao-Liang Chang ,  Kai-Ling Zhang

IPC: C12N5/0775 ,  A61P19/02

CPC classification number: C12N5/0667 ,  A61P19/02 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2501/10

Abstract: The present disclosure provides a method for preparing a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors, the composition prepared by the method, and use of the composition for treating arthritis. The composition of the present disclosure achieves the effect of treating arthritis through various efficacy experiments.