Spatial Light Interference Microscopy and Fourier Transform Light Scattering for Cell and Tissue Characterization
    1.
    发明申请
    Spatial Light Interference Microscopy and Fourier Transform Light Scattering for Cell and Tissue Characterization 有权
    空间光干涉显微镜和傅里叶变换光散射用于细胞和组织表征

    公开(公告)号:US20120105858A1

    公开(公告)日:2012-05-03

    申请号:US13342350

    申请日:2012-01-03

    IPC分类号: G01B9/02 G02F1/01 B82Y20/00

    摘要: Methods and apparatus for rendering quantitative phase maps across and through transparent samples. A broadband source is employed in conjunction with an objective, Fourier optics, and a programmable two-dimensional phase modulator to obtain amplitude and phase information in an image plane. Methods, referred to as Fourier transform light scattering (FTLS), measure the angular scattering spectrum of the sample. FTLS combines optical microscopy and light scattering for studying inhomogeneous and dynamic media. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. Full angular information, limited only by the microscope objective, is obtained from extremely weak scatterers, such as a single micron-sized particle. A flow cytometer may employ FTLS sorting.

    摘要翻译: 通过透明样品绘制定量相位图的方法和装置。 结合物镜,傅立叶光学元件和可编程的二维相位调制器采用宽带源,以获得图像平面中的幅度和相位信息。 称为傅里叶变换光散射(FTLS)的方法测量样品的角散射光谱。 FTLS结合光学显微镜和光散射来研究不均匀和动态的介质。 FTLS依赖于量化与相干图像场相关联的光学相位和振幅,并将其数值传播到散射平面。 仅由显微镜物镜限制的全角度信息是从极微弱的散射体,如单个微米尺寸的粒子获得的。 流式细胞仪可采用FTLS分选。

    Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization
    2.
    发明申请
    Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization 有权
    空间光干涉显微镜和傅里叶变换光散射用于细胞和组织表征

    公开(公告)号:US20090290156A1

    公开(公告)日:2009-11-26

    申请号:US12454660

    申请日:2009-05-21

    IPC分类号: G01N21/53 G02F1/01

    摘要: Methods and apparatus for rendering quantitative phase maps across and through transparent samples. A broadband source is employed in conjunction with an objective, Fourier optics, and a programmable two-dimensional phase modulator to obtain amplitude and phase information in an image plane. Methods, referred to as Fourier transform light scattering (FTLS), measure the angular scattering spectrum of the sample. FTLS combines optical microscopy and light scattering for studying inhomogeneous and dynamic media. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. Full angular information, limited only by the microscope objective, is obtained from extremely weak scatterers, such as a single micron-sized particle. A flow cytometer may employ FTLS sorting.

    摘要翻译: 通过透明样品绘制定量相位图的方法和装置。 结合物镜,傅立叶光学元件和可编程的二维相位调制器采用宽带源,以获得图像平面中的幅度和相位信息。 称为傅里叶变换光散射(FTLS)的方法测量样品的角散射光谱。 FTLS结合光学显微镜和光散射来研究不均匀和动态的介质。 FTLS依赖于量化与相干图像场相关联的光学相位和振幅,并将其数值传播到散射平面。 仅由显微镜物镜限制的全角度信息是从极微弱的散射体,如单个微米尺寸的粒子获得的。 流式细胞仪可采用FTLS分选。

    Jones phase microscopy of transparent samples
    4.
    发明授权
    Jones phase microscopy of transparent samples 有权
    透明样品的琼斯相显微镜

    公开(公告)号:US07940399B2

    公开(公告)日:2011-05-10

    申请号:US12460808

    申请日:2009-07-24

    IPC分类号: G01B11/02

    摘要: Methods for displaying anisotropic properties of an object. The object is illuminated with a first test beam characterized by a first polarization that, after traversing the object, is combined with a reference beam. The combined light of the first transmitted test beam and the reference beam is analyzed by a first pair of polarization analyzers, and interference created between the first transmitted test beam and the reference beam as analyzed by the first pair of analyzers is detected to derive intensity, phase and polarization of the first transmitted test beam. The same is then done with a second test beam that has a polarization with a component orthogonal to the first polarization. Based on the two analyzed beams, complex elements of a Jones matrix associated with the object in a local coordinate system are determined and a plurality of tangible images are displayed that characterize the object based on the complex elements of the Jones matrix.

    摘要翻译: 显示对象各向异性的方法。 物体被第一测试光束照亮,第一测试光束的特征在于第一极化,在穿过物体之后,与参考光束组合。 通过第一对偏振分析器分析第一透射测试光束和参考光束的组合光,并且检测由第一对分析器分析的在第一透射测试光束和参考光束之间产生的干涉,以导出强度, 第一个发射的测试光束的相位和极化。 然后用具有与第一极化正交的分量的偏振的第二测试光束进行相同的操作。 基于两个分析的波束,确定与局部坐标系中的对象相关联的Jones矩阵的复数元素,并且基于Jones矩阵的复数元素来显示表征对象的多个有形图像。

    Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization
    5.
    发明授权
    Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization 有权
    空间光干涉显微镜和傅里叶变换光散射用于细胞和组织表征

    公开(公告)号:US08184298B2

    公开(公告)日:2012-05-22

    申请号:US12454660

    申请日:2009-05-21

    IPC分类号: G01B9/02 G01J3/45 G02B21/00

    摘要: Methods and apparatus for rendering quantitative phase maps across and through transparent samples. A broadband source is employed in conjunction with an objective, Fourier optics, and a programmable two-dimensional phase modulator to obtain amplitude and phase information in an image plane. Methods, referred to as Fourier transform light scattering (FTLS), measure the angular scattering spectrum of the sample. FTLS combines optical microscopy and light scattering for studying inhomogeneous and dynamic media. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. Full angular information, limited only by the microscope objective, is obtained from extremely weak scatterers, such as a single micron-sized particle. A flow cytometer may employ FTLS sorting.

    摘要翻译: 通过透明样品绘制定量相位图的方法和装置。 结合物镜,傅立叶光学元件和可编程的二维相位调制器采用宽带源,以获得图像平面中的幅度和相位信息。 称为傅里叶变换光散射(FTLS)的方法测量样品的角散射光谱。 FTLS结合光学显微镜和光散射来研究不均匀和动态的介质。 FTLS依赖于量化与相干图像场相关联的光学相位和振幅,并将其数值传播到散射平面。 仅由显微镜物镜限制的全角度信息是从极微弱的散射体,如单个微米尺寸的粒子获得的。 流式细胞仪可采用FTLS分选。

    Jones phase microscopy of transparent samples
    6.
    发明申请
    Jones phase microscopy of transparent samples 有权
    透明样品的琼斯相显微镜

    公开(公告)号:US20100027027A1

    公开(公告)日:2010-02-04

    申请号:US12460808

    申请日:2009-07-24

    IPC分类号: G01B9/02

    摘要: Methods for displaying anisotropic properties of an object. The object is illuminated with a first test beam characterized by a first polarization that, after traversing the object, is combined with a reference beam. The combined light of the first transmitted test beam and the reference beam is analyzed by a first pair of polarization analyzers, and interference created between the first transmitted test beam and the reference beam as analyzed by the first pair of analyzers is detected to derive intensity, phase and polarization of the first transmitted test beam. The same is then done with a second test beam that has a polarization with a component orthogonal to the first polarization. Based on the two analyzed beams, complex elements of a Jones matrix associated with the object in a local coordinate system are determined and a plurality of tangible images are displayed that characterize the object based on the complex elements of the Jones matrix.

    摘要翻译: 显示对象各向异性的方法。 物体被第一测试光束照亮,第一测试光束的特征在于第一极化,在穿过物体之后,与参考光束组合。 通过第一对偏振分析器分析第一透射测试光束和参考光束的组合光,并且检测由第一对分析器分析的在第一透射测试光束和参考光束之间产生的干涉,以导出强度, 第一个发射的测试光束的相位和极化。 然后用具有与第一极化正交的分量的偏振的第二测试光束进行相同的操作。 基于两个分析的波束,确定与局部坐标系中的对象相关联的Jones矩阵的复数元素,并且基于Jones矩阵的复数元素来显示表征对象的多个有形图像。

    MULTIPLYING ANALOG TO DIGITAL CONVERTER AND METHOD
    8.
    发明申请
    MULTIPLYING ANALOG TO DIGITAL CONVERTER AND METHOD 有权
    将数字模拟转换为数字转换器和方法

    公开(公告)号:US20170019121A1

    公开(公告)日:2017-01-19

    申请号:US15277434

    申请日:2016-09-27

    IPC分类号: H03M1/12 H03M1/10

    摘要: A multiplying analog to digital converter including an analog to digital converter (ADC) having a sample input and a feedback input and an ADC output configured with a feedback path configured to couple the ADC output to a digital to analog converter. A feedback attenuator is disposed in the feedback path, the feedback attenuator being configured to attenuate a feedback signal coupled to the feedback input, the feedback attenuator being configured to provide analog multiplication observed at the ADC output. A barrel shifter is configured to provide digital multiplication of the ADC output. The feedback attenuator may be configured as a divider network. The feedback attenuator may be configured to provide attenuation using only passive components. The feedback attenuator may be configured as a capacitive divider network. The feedback attenuator may be configured to provide attenuation ranging between 1 and 0.5.

    摘要翻译: 包括具有采样输入和反馈输入的模/数转换器(ADC)的乘法模数转换器和配置有将ADC输出耦合到数模转换器的反馈路径的ADC输出。 反馈衰减器设置在反馈路径中,反馈衰减器被配置为衰减耦合到反馈输入的反馈信号,该反馈衰减器被配置为提供在ADC输出处观察到的模拟乘法。 桶形移位器被配置为提供ADC输出的数字乘法。 反馈衰减器可以被配置为分频器网络。 反馈衰减器可以被配置为仅使用无源部件来提供衰减。 反馈衰减器可以被配置为电容分压网络。 反馈衰减器可以被配置为提供范围在1和0.5之间的衰减。

    LUMINAIRE WITH ANGLED REFLECTOR
    9.
    发明申请
    LUMINAIRE WITH ANGLED REFLECTOR 审中-公开
    带有反射镜的灯泡

    公开(公告)号:US20150330599A1

    公开(公告)日:2015-11-19

    申请号:US14277494

    申请日:2014-05-14

    IPC分类号: F21V7/04 F21K99/00 F21V7/00

    摘要: A luminaire includes a plurality of solid state light sources arranged to emit light in respective angular distributions that are centered along a common optical axis. A reflector including one or more reflecting surfaces is arranged along a periphery of the solid state light sources. The reflector is positioned to receive light emitted at relatively high propagation angles from the solid state light sources, with respect to the optical axis, and reflects the light to have reduced propagation angles, with respect to the optical axis. The one or more reflecting surfaces have a generally flat cross-section that is angled away from the optical axis, and are arranged in a pattern around the periphery of the solid state light sources. The one or more reflecting surfaces can reflect specularly or diffusely.

    摘要翻译: 照明器包括多个固态光源,其被布置成发射沿着公共光轴居中的各个角度分布中的光。 包括一个或多个反射表面的反射器沿着固态光源的周边布置。 反射器被定位成接收相对于光轴从固态光源以相对高的传播角度发射的光,并相对于光轴反射光以减小传播角度。 一个或多个反射表面具有远离光轴成角度的大致平坦的横截面,并且以围绕固态光源的周边的图案布置。 一个或多个反射表面可以反射或漫反射。

    BATWING LIGHT BEAM DISTRIBUTION USING DIRECTIONAL OPTICS
    10.
    发明申请
    BATWING LIGHT BEAM DISTRIBUTION USING DIRECTIONAL OPTICS 审中-公开
    使用方向光学的聚光灯分布

    公开(公告)号:US20150276145A1

    公开(公告)日:2015-10-01

    申请号:US14242238

    申请日:2014-04-01

    IPC分类号: F21K99/00 F21V7/00

    摘要: A luminaire is provided to redirect incidence light from one or more solid state light sources to a batwing distribution with both tunable peak angle and beam width. The peak angle is able to be tuned from 90 degree to 0 degree from the incidence direction with very high efficiency. The beam width is able to be tuned with either narrow beam angle solid state light sources for high efficiency or TIR lens or the optical properties of a reflector for versatility. Uniform illuminance distribution is thus achieved across a wide field with or without a prism or diffuser cover.

    摘要翻译: 提供照明器以将来自一个或多个固态光源的入射光重定向到具有可调峰值角和光束宽度的蝙蝠分布。 峰值角度能够以非常高的效率从入射方向从90度调整到0度。 波束宽度能够用于高效率的窄光束角固态光源或TIR透镜或用于多功能性的反射器的光学特性来调谐。 因此,在具有或不具有棱镜或扩散器盖的宽场中实现均匀的照度分布。