-
公开(公告)号:US20130129800A1
公开(公告)日:2013-05-23
申请号:US13813422
申请日:2011-07-29
申请人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano' , Enzo Meani , Edgardo Cremascoli
发明人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano' , Enzo Meani , Edgardo Cremascoli
IPC分类号: A61K47/36
CPC分类号: A61K47/36 , A61L27/20 , A61L27/34 , A61L27/52 , A61L27/54 , A61L2300/258 , A61L2300/402 , A61L2300/414 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要: The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention.
摘要翻译: 本发明涉及基于透明质酸的衍生物的水凝胶,其比单独的透明质酸对化学和酶降解更具抗性,并且具有化学和机械性质的混合物,使得它们在几种手术中是最佳用途,例如 用于骨折或腔内注射和用于在整形外科手术中生产假体涂层,作为化妆品和上颌面手术中的填充剂,作为防止腹部和腹部/骨盆手术中术后粘连的抗粘连屏障,以及 一般手术。 这些水凝胶可以装载几种具有药理和生物活性的化合物,然后在介入部位从水凝胶中释放。
-
公开(公告)号:US08529935B2
公开(公告)日:2013-09-10
申请号:US13147153
申请日:2010-01-29
申请人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano , Enzo Meani , Edgardo Cremascoli
发明人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano , Enzo Meani , Edgardo Cremascoli
IPC分类号: A61F2/00 , A61K33/00 , A61K6/083 , A61K31/70 , A61K31/715 , A61K31/65 , A61K31/497 , A61K31/44 , A61K33/38 , A61K33/34 , A61P31/00
CPC分类号: C08L5/08 , A61L27/34 , A61L27/52 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/604 , C08B37/0072
摘要: The present invention relates to hydrogels endowed with antibacterial properties, to be used for injection in damaged bones or in the production of antibacterial coatings of prostheses for implant in the human or animal body, obtained by loading with antibacterial agents hydrogels formed by derivatives of hyaluronic acid; the invention also relates to a kit of parts for producing the antibacterial hydrogels.
摘要翻译: 本发明涉及具有抗菌特性的水凝胶,用于在受损骨骼中注射或用于人体或动物体内植入假体的抗菌涂层的制备,其通过装载抗菌剂由透明质酸衍生物形成的水凝胶 ; 本发明还涉及用于生产抗菌水凝胶的试剂盒。
-
公开(公告)号:US09283283B2
公开(公告)日:2016-03-15
申请号:US13813422
申请日:2011-07-29
申请人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano′ , Enzo Meani , Edgardo Cremascoli
发明人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano′ , Enzo Meani , Edgardo Cremascoli
IPC分类号: A61K47/36 , A61L27/20 , A61L27/34 , A61L27/52 , A61L27/54 , C08B37/08 , C08J3/075 , C08L5/08
CPC分类号: A61K47/36 , A61L27/20 , A61L27/34 , A61L27/52 , A61L27/54 , A61L2300/258 , A61L2300/402 , A61L2300/414 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要: The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention.
摘要翻译: 本发明涉及基于透明质酸的衍生物的水凝胶,其比单独的透明质酸对化学和酶降解更具抗性,并且具有化学和机械性质的混合物,使得它们在几种手术中是最佳用途,例如 用于骨折或腔内注射和用于在整形外科手术中生产假体涂层,作为化妆品和上颌面手术中的填充剂,作为防止腹部和腹部/骨盆手术中术后粘连的抗粘连屏障,以及 一般手术。 这些水凝胶可以装载几种具有药理和生物活性的化合物,然后在介入部位从水凝胶中释放。
-
公开(公告)号:US20110280921A1
公开(公告)日:2011-11-17
申请号:US13147153
申请日:2010-01-29
申请人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano , Enzo Meani , Edgardo Cremascoli
发明人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano , Enzo Meani , Edgardo Cremascoli
IPC分类号: A61K9/00 , A61K33/34 , A61K33/30 , A61K33/24 , B05D1/00 , A61K38/14 , A61K31/7036 , A61K31/7048 , A61K31/702 , A61K31/65 , A61K31/5365 , A61K31/496 , A61K31/4409 , A61K31/343 , A61K31/132 , A61P31/04 , A61P31/10 , B05D1/18 , B05D1/02 , A61K33/38
CPC分类号: C08L5/08 , A61L27/34 , A61L27/52 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/604 , C08B37/0072
摘要: The present invention relates to hydrogels endowed with antibacterial properties, to be used for injection in damaged bones or in the production of antibacterial coatings of prostheses for implant in the human or animal body, obtained by loading with antibacterial agents hydrogels formed by derivatives of hyaluronic acid; the invention also relates to a kit of parts for producing the antibacterial hydrogels.
摘要翻译: 本发明涉及具有抗菌特性的水凝胶,用于在受损骨骼中注射或用于人体或动物体内植入假体的抗菌涂层的制备,其通过装载抗菌剂由透明质酸衍生物形成的水凝胶 ; 本发明还涉及用于生产抗菌水凝胶的试剂盒。
-
-
-